Long- and short-term protective responses of rice seedling to combat Cr(VI) toxicity

Dubey, Sonali; Gupta, Anubhuti; Khare, Aditi; Jain, Gauransh; Bose, Sagarika; Rani, Vibha

doi:10.1007/s11356-018-3422-z

Cited by 11 publications

(1 citation statement)

References 44 publications

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“…In plants, L-Pro is accumulated after exposure to heavy metals such as cadmium, chromium, and zinc (Sharma et al, 1998;Verbruggen and Hermans, 2008;Hayat et al, 2012;Dubey et al, 2018;Dong et al, 2021;Pejam et al, 2021;Zdunek-Zastocka et al, 2021), and this mitigates the detrimental effects of cadmium in young olive plants (Zouari et al, 2016) and cultured tobacco cells (Islam et al, 2009). Heavy metal toxicity is usually associated with ROS accumulation (Figure 4).…”

Section: Heavy Metal Detoxificationmentioning

confidence: 99%

The Multifaceted Roles of Proline in Cell Behavior

Patriarca

Cermola

D’Aniello

et al. 2021

Front. Cell Dev. Biol.

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Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino acid is: (i) A main precursor of extracellular collagens (the most abundant human proteins), antimicrobial peptides (involved in innate immunity), salivary proteins (astringency, teeth health) and cornifins (skin permeability); (ii) an energy source for pathogenic bacteria, protozoan parasites, and metastatic cancer cells, which engage in extracellular-protein degradation to invade their host; (iii) an antistress molecule (an osmolyte and chemical chaperone) helpful against various potential harms (UV radiation, drought/salinity, heavy metals, reactive oxygen species); (iv) a neural metabotoxin associated with schizophrenia; (v) a modulator of cell signaling pathways such as the amino acid stress response and extracellular signal-related kinase pathway; (vi) an epigenetic modifier able to promote DNA and histone hypermethylation; (vii) an inducer of proliferation of stem and tumor cells; and (viii) a modulator of cell morphology and migration/invasiveness. We highlight how proline metabolism impacts beneficial tissue regeneration, but also contributes to the progression of devastating pathologies such as fibrosis and metastatic cancer.

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