Long&amp;ndash;Term Outcome of Transrectal High&amp;ndash; Intensity Focused Ultrasound Therapy for Benign Prostatic Hyperplasia

Madersbacher, Stephan; Schatzl, Georg; Djavan, Bob; Stulnig, Thomas M.; Marberger, Michael

doi:10.1159/000020219

Cited by 107 publications

(56 citation statements)

References 23 publications

(28 reference statements)

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“…In these studies, ultrasound has either been investigated for its ability to heat tumor tissues for direct treatment of small and localized cancerous tumors (9,10) or as adjuvant therapy to increase the efficacy of radiotherapy (11) and chemotherapy (12). In earlier studies, we reported that mild hyperthermia (41°C) as induced by ultrasound (USHT) could be used to increase cellular uptake and cytotoxicity of P-gp substrate doxorubicin in P-gp overexpressing cells (13).…”

mentioning

confidence: 99%

Overcoming MDR by Ultrasound-Induced Hyperthermia and P-Glycoprotein Modulation

Yang

Lillehei

Cobb

et al. 2001

Biochemical and Biophysical Research Communications

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mentioning

confidence: 99%

Overcoming MDR by Ultrasound-Induced Hyperthermia and P-Glycoprotein Modulation

Yang

Lillehei

Cobb

et al. 2001

Biochemical and Biophysical Research Communications

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“…This result is supported by Roar (2015) study which showed that most patients with BPH underwent the TURP therapy and most frequently at the age of 73 to 77 years (24.6%) (Roar, 2015). Monopolar TURP remains the golden standard treatment for patients with bothersome, moderate or severe LUTS who request active treatment or who either fail or do not want medical therapy (Roar, 2015;Nickel et al, 2010;Hindley et al, 2001;Madersbacher et al, 2000;Roehrborn et al, 2007;Vesely et al, 2006;Fowler et al, 2005). Bipolar TURP has evolved as an equivalent alternative to monopolar technique.…”

Section: Discussionmentioning

confidence: 99%

The characteristics of benign prostatic hyperplasia (BPH) in Rumah Sakit Umum Haji Medan

Rahman¹

2018

J. Public Health Epidemiol.

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Benign prostatic hyperplasia (BPH) is an enlarged prostate gland caused by progressive hyperplasia of glandular cells or stoma cells from prostate tissues. BPH is a common problem that increases inThe highest co morbidity is hypertension (20 people (23.8%). The patients that had BPH most in RSU Haji Medan were 60 to 70 years old; the chief complaint is not being able to urinate; common size of prostate volume is 40 to 60 g; the most common therapy that is used is TURP, and the highest co morbidity is hypertension.

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“…[7][8][9] In consideration of the role of vascular occlusion by HIFU, many studies demonstrated that HIFU could stop the bleeding from injuries of different organs. [10][11][12][13][14][15][16][17][18][19][20] Spleen haemostasis is one of the clinical issues we often face. HIFU is effective in achieving haemostasis in haemorrhagic spleen models of pigs and rabbits, 3,4 and no major adverse effects were observed.…”

Section: Discussionmentioning

confidence: 99%

High-intensity focused ultrasound ablation: an effective and safe treatment for secondary hypersplenism

Zhu¹,

Mei²,

L³

et al. 2014

BJR

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Objective: Hypersplenism is a common disease. The conventional treatment is splenectomy and partial splenic embolization; however, both of them have high complication rates and technical defects. Therefore, safer and more effective techniques should be considered for the treatment of hypersplenism. High-intensity focused ultrasound (HIFU) may provide an effective and safe way for treatment of hypersplenism. Therefore, we conducted this study to assess the safety and efficacy of HIFU in treatment of secondary hypersplenism. Methods: A total of 28 patients who suffered from secondary hypersplenism were treated with HIFU ablation. All patients who underwent HIFU were closely followedup over a year. MRI scan was performed, and the spleens were observed. Blood counts and liver function tests were also carried out.Results: In the follow-up process, the levels of white blood cells and platelets in the blood after HIFU were significantly higher than those before HIFU, liver function also improved after HIFU treatment. In addition, the symptoms were ameliorated significantly or even disappeared. The MRI showed that the ablation area had turned into a non-perfused volume, and after 12 months of HIFU ablation, the ablated area shrank evidently; the sunken spleen formed a lobulated shape and the splenic volume decreased. Conclusion: HIFU ablation is a safe, effective and noninvasive approach for secondary hypersplenism. Advances in knowledge: For the first time we used HIFU ablation to treat secondary hypersplenism. It not only expands indications of HIFU but also provides better choice for the treatment of secondary hypersplenism.Hypersplenism is a common manifestation in cirrhotic patients with portal hypertension. Liangpunsakul et al 1 reported that 70-80% of cirrhotic patients with portal hypertension have different degrees of splenomegaly and hypersplenism. Hypersplenism is a clinical syndrome characterized by splenomegaly, a variable combination of anaemia, leucopenia and/or thrombocytopaenia, compensatory bone marrow hyperplasia, reduced immunity and improvement after splenectomy. 1 The conventional treatment for patients with hypersplenism is splenectomy. However, after the first report of overwhelming post-splenectomy infection, clinical practitioners started realizing the important immunological function of the spleen. What is more, splenectomy is associated with increased risk of splenic vein thrombosis, secondary thrombocythemia and infection, particularly with encapsulated micro-organisms. 2 Several studies have shown that the spleen is an organ with a variety of important functions such as anti-infection and antitumour immunity. Therefore, it is important to retain the splenic function as much as possible when using splenomegaly treatment. Recently, partial splenic embolization (PSE) has been used in the treatment of splenomegaly and hypersplenism, but it has high incidence of complications. Local ablation therapies, such as radiofrequency ablation (RFA) and microwave ablation, also have marked improvement for...

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Long–Term Outcome of Transrectal High– Intensity Focused Ultrasound Therapy for Benign Prostatic Hyperplasia

Cited by 107 publications

References 23 publications

Overcoming MDR by Ultrasound-Induced Hyperthermia and P-Glycoprotein Modulation

Overcoming MDR by Ultrasound-Induced Hyperthermia and P-Glycoprotein Modulation

The characteristics of benign prostatic hyperplasia (BPH) in Rumah Sakit Umum Haji Medan

High-intensity focused ultrasound ablation: an effective and safe treatment for secondary hypersplenism

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