Long-acting reversible contraception by effervescent microneedle patch

Li, Wei; Tang, Jie; Terry, Richard N.; Li, Song; Brunie, Aurélie; Callahan, Rebecca L.; Noel, Richard K.; Rodríguez, Carlos Aníbal; Schwendeman, Steven P.; Prausnitz, Mark R.

doi:10.1126/sciadv.aaw8145

Cited by 165 publications

(146 citation statements)

References 45 publications

Supporting

Mentioning

142

Contrasting

Unclassified

Order By: Relevance

“…recently reported a MN patch containing an effervescent backing layer between MN tips and the adhesive base, that reacts in contact with ISF and facilitates the rapid separation of MN tips from the patch. [ 3 ] Barb‐structures were constructed on the surface of MN tips to mechanically interlock with tissue for enhanced tissue adhesion. [ 2b,4 ]…”

Section: Introductionmentioning

confidence: 99%

A Double‐Layered Microneedle Platform Fabricated through Frozen Spray‐Coating

Ning

Wiraja

Lio

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

This work reports a frozen spray-coating method for the fabrication of double-layered microneedles (MNs). Taking swellable methacrylated hyaluronic acid (MeHA)-derived MNs as the model, both hydrophobic molecules (Nile red, Cy5) and hydrophilic ones (FITC, FITC-Dextran, Insulin) can be homogeneously coated without impacting the mechanical properties of the original MeHA MNs. The prepared double-layered MNs can execute multiple roles. It is demonstrated that insulin-coated MeHA double-layered MNs allow the effective delivery of the insulin into circulation of mice for controlling the blood glucose level while they also permit the extraction of skin interstitial fluid for the timely analysis of the biomarker (glucose).

show abstract

Section: Introductionmentioning

confidence: 99%

A Double‐Layered Microneedle Platform Fabricated through Frozen Spray‐Coating

Ning

Wiraja

Lio

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…The release time of drugs from the dissolving MNs ranges from minutes to days [103,104], which depends on the dissolution nature of polymers, fabrication process, geometry of MN, and water content of insertion part. Accordingly, release can possibly sustain for months by choosing appropriate types of polymer and fabrication methods [105]. Because of their biodegradability, dissolving MNs do not leave sharp biohazardous wastes in skin.…”

Section: Dissolving Mnsmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

View full text Add to dashboard Cite

Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

show abstract

“…Organic solvents (e.g., dichloromethane, dioxane, tetrahydrofuran, dimethylformamide, diglyme, etc.) are generally employed as vehicles to dissolve PLGA and drugs at room temperature [10][11][12][13]. The fabrication of bubble-microneedle patches encapsulating levonorgestrel (LNG) using dioxane and tetrahydrofuran to dissolve PLGA and polylactic acid has been reported.…”

Section: Introductionmentioning

confidence: 99%

Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles

et al. 2020

View full text Add to dashboard Cite

Hydrophobic drugs wrapped in poly (lactic-co-glycolic acid) (PLGA)-based microneedles (MNs) require a long time to release completely. To obtain the desired duration, it is still necessary to modulate the release of hydrophobic drugs from MNs, while the PLGA composition is unchangeable. In this work, implantable PLGA microneedles (IPMNs) composed of PLGA arrowheads encapsulating levonorgestrel (LNG) and a water-soluble supporting array were designed. We explored trehalose used as a porogen on the release of hydrophobic LNG from PLGA-based MNs. Varying the trehalose content in PLGA arrowheads could induce different rates of drug release. The highest cumulative release of LNG was 76.2 ± 3.9% for IPMNs with 33.3% trehalose during 21 days in vitro, while the cumulative release of LNG was 60.4 ± 3.5% for IPMNs without trehalose. Pharmacokinetic results in rats showed that plasma levels of LNG were sustained for 13 days for IPMNs with 33.3% trehalose and 16 days for IPMNs without trehalose. Furthermore, the PLGA arrowheads with trehalose degraded more rapidly than those without trehalose over 21 days in rats. Consequently, using trehalose as a porogen was a feasible approach to modulate the release of a hydrophobic drug from PLGA-based MNs.

show abstract

Long-acting reversible contraception by effervescent microneedle patch

Cited by 165 publications

References 45 publications

A Double‐Layered Microneedle Platform Fabricated through Frozen Spray‐Coating

A Double‐Layered Microneedle Platform Fabricated through Frozen Spray‐Coating

Engineering Microneedles for Therapy and Diagnosis: A Survey

Exploring Trehalose on the Release of Levonorgestrel from Implantable PLGA Microneedles

Contact Info

Product

Resources

About