Long‐acting recombinant follicle‐stimulating hormone in random‐start ovarian stimulation protocols for fertility preservation in women with cancer

Sarais, Veronica; Paffoni, Alessio; Pagliardini, Luca; Filippi, Francesca; Martinelli, Fabio; Mangili, Giorgia; Candiani, Massimo; Papaleo, Enrico

doi:10.1111/aogs.13146

Cited by 14 publications

(25 citation statements)

References 23 publications

(29 reference statements)

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“…Fourthly, the peculiar policy adopted in our Unit of a systematic use of long-acting recombinant FSH may hamper inferences, in particular in contexts where this drug is not yet available. In this regard, it has however to be noted that we failed to highlight relevant differences between long-acting recombinant FSH and daily FSH in a previous comparative study of our group [23]. Finally, albeit relatively large, we have to recognize that our sample size is insufficient to draw firm conclusions.…”

Section: Discussionmentioning

confidence: 67%

“…From a therapeutic point of view, they were informed about the possible benefits of the assumption of GnRH analogues during chemotherapy and on the possibility of cryopreserving ovarian tissue or oocytes. The latter is generally recommended in adult women because of the local higher know-how [22,23] and because it is no more considered experimental [24]. All selected women underwent transvaginal sonography to assess AFC at the time of referral regardless of the phase of the cycle.…”

Section: Methodsmentioning

confidence: 99%

“…Women opting for oocyte cryopreservation were treated according to a random start protocol as previously reported [23]. Briefly, women initiated gonadotropin treatment on the day of referral, irrespective of their menstrual cycle date.…”

Section: Methodsmentioning

confidence: 99%

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Fertility preservation in women with malignancies: the accuracy of antral follicle count collected randomly during the menstrual cycle in predicting the number of oocytes retrieved

Filippi

Martinelli

Paffoni

et al. 2018

J Assist Reprod Genet

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Purpose To evaluate the capacity of random antral follicle count (AFC), i.e., AFC recorded at any time during the menstrual cycle, to predict the number of retrieved mature oocytes in women with malignancies undergoing random start ovarian hyperstimulation Methods A consecutive series of 72 women with malignancies who underwent ovarian hyperstimulation aimed at egg freezing between July 2014 and December 2016 was retrospectively reviewed. A standardized random start protocol was used for all women. AFC and serum AMH were systematically assessed prior to initiating ovarian hyperstimulation. The main outcome was the retrieval of ≥ 10 mature oocytes. The accuracy of random AFC was tested with the c-statistics (area under the ROC curve). Results For the whole cohort, the c-statistics for the prediction of ≥ 10 mature oocytes using AFC and serum AMH were similar. Specifically, the areas under the curve were 0.76 (95%CI 0.66-0.87) and 0.82 (95%CI 0.72-0.92), respectively (p = ns). Moreover, when considering the subgroup of women recruited after day 5 of the cycle (proper random start, n = 52), the areas under the curve did not also differ. Specifically, they resulted in 0.77 (95%CI 0.64-0.89) and 0.83 (95%CI 0.72-0.95), respectively (p = ns). Conclusions AFC collected at any time during the menstrual cycle can provide valuable information for the counseling of women with malignancies scheduled for oocyte cryopreservation. Its reliability appears to be non-inferior to that of serum AMH.

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Section: Discussionmentioning

confidence: 67%

Section: Methodsmentioning

confidence: 99%

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Fertility preservation in women with malignancies: the accuracy of antral follicle count collected randomly during the menstrual cycle in predicting the number of oocytes retrieved

Filippi

Martinelli

Paffoni

et al. 2018

J Assist Reprod Genet

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“…5 Several reports of advances in fertility preservation have been previously published in AOGS. [6][7][8][9][10] In this Special Issue of AOGS, worldwide leading researchers in the field of fertility preservation have contributed with state-of-the-art reviews that cover the most relevant aspects of fertility preservation among women and girls. EDITORIAL Fertility preservation has grown into a truly multidisciplinary clinical field over the last two decades.…”

Section: Twenty Years Of Development In Fertility Preservation Of Wommentioning

confidence: 99%

Twenty years of development in fertility preservation of women and girls and the challenges that remain

Rodriguez‐Wallberg

Gemzell‐Danielsson

2019

Acta Obstet Gynecol Scand

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“…The patent clinical advantages of random start protocols have facilitated their rapid spread worldwide. Several case series and comparative studies have been published over the last few years 4,10,[12][13][14][15][16][17][18] . They are reassuring and generally support the feasibility and effectiveness of these protocols.…”

mentioning

confidence: 99%

The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols

Filippi

Somigliana

Busnelli

et al. 2020

Sci Rep

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The advent of random start protocols to shorten the time needed to store oocytes in women with malignancies has represented an important improvement in the field of fertility preservation. However, Randomized Controlled Trials are difficult to implement in this area and available evidence that supports this approach remains modest. To shed more light on this issue, we compared the follicular development between the ovary carrying the dominant follicle or the corpus luteum and the contralateral resting ovary in 90 women who underwent random start controlled ovarian stimulation (COS). In fact, ovarian response did not differ between the two ovaries. Subgroup analyses according to the phase of the cycle at the initiation of COS, the type of malignancy, the use of letrozole and the magnitude of the ovarian response did not allow to identify any condition showing a difference in the follicular response between the active and the resting ovaries. In conclusion, follicular growth does not seem to be perturbed by the presence of a dominant follicle or a corpus luteum.

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Long‐acting recombinant follicle‐stimulating hormone in random‐start ovarian stimulation protocols for fertility preservation in women with cancer

Abstract: The use of long-acting recombinant FSH in random-start protocols for fertility preservation appears to be a valuable option.

Cited by 14 publications

References 23 publications

Fertility preservation in women with malignancies: the accuracy of antral follicle count collected randomly during the menstrual cycle in predicting the number of oocytes retrieved

Fertility preservation in women with malignancies: the accuracy of antral follicle count collected randomly during the menstrual cycle in predicting the number of oocytes retrieved

Twenty years of development in fertility preservation of women and girls and the challenges that remain

The presence of dominant follicles and corpora lutea does not perturb response to controlled ovarian stimulation in random start protocols

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