Long-acting implantable devices for the prevention and personalised treatment of infectious, inflammatory and chronic diseases

Abstract

Accepted/In press). Long-acting implantable devices for the prevention and personalised treatment of infectious, inflammatory and chronic diseases. Journal of Drug Delivery Science and Technology.

Potential next-generation medications for self-administered platforms

“…These biocompatible nanodevices combined with computer chips can further expedite the application of artificial intelligence in drug-delivery systems. The integration of targeted stimuli-responsive drug delivery systems [ 15 ] Compared to traditional monotonic drug-release manners, newer drug carriers can precisely control the release time and quantity of drugs introduced into a patient's body by programmed and on-demand means [ 15 ]. With stimuli-responsive designs, drugs are produced and administered in inactivated forms and then activated by specific pathophysiological or physiological microenvironments at the target site, which minimizes side effects [ 7 ].…”

“…The integration of targeted stimuli-responsive drug delivery systems [ 15 ] Compared to traditional monotonic drug-release manners, newer drug carriers can precisely control the release time and quantity of drugs introduced into a patient's body by programmed and on-demand means [ 15 ]. …”

Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants

“…In recent years, researchers have devised novel strategies to improve and enhance properties of drugs by encapsulating them in modified/ nanosized carriers to exclusively release these drug molecules to the site of action in a controlled manner [172]. To reach this goal, 3DP LADDS have been developed to deliver drug molecules for a long period of time to the sites of action [173]. 3DP LADDS are promising for long term and local delivery of drugs with improved pharmacokinetics properties.…”

Polysaccharide 3D Printing for Drug Delivery Applications

“…In parallel to mass production, a real potential lies in the field of personalized medical treatment [17,18]. This applies, Pharmaceutics 2022, 14, 145 2 of 32 of course, to tissue engineering and regenerative medicine [19][20][21], where scaffolds with complicated structures can be printed according to the exact needs of the patient; but it is also a promising development for pharmaceutical treatments [22][23][24][25][26][27]. Currently, drugs benefit, to their highest efficiency, only a small percentage of patients [28].…”