Long-acting formulation strategies for protein and peptide delivery in the treatment of PSED

Garkal, Atul; Bangar, Priyanka; Rajput, Amarjitsing; Dhas, Namdev; Sami, Anam; Mathur, Khushboo; Joshi, Shubham; Dhuri, Sonika; Parikh, Dhaivat; Mutalik, Srinivas; Mehta, Tejal

doi:10.1016/j.jconrel.2022.08.040

Cited by 9 publications

(5 citation statements)

References 312 publications

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“…A combination of surfactants or polymers stabilized this matrix ( 64 ). SLNs are significantly advantageous, with characteristics such as long-term physical stability, site-specific targeting, and the potential for both hydrophilic and lipophilic medicines to have regulated release, labile pharmaceutical safety, low cost, readiness, and nontoxicity ( 65 ). Furthermore, SLNs caused very little toxicity to human granulocytes.…”

Section: Classification Of Lbnpsmentioning

confidence: 99%

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Waheed,

Ali,

Tabassum

et al. 2024

Front. Oncol.

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Cancer is a severe disease that results in death in all countries of the world. A nano-based drug delivery approach is the best alternative, directly targeting cancer tumor cells with improved drug cellular uptake. Different types of nanoparticle-based drug carriers are advanced for the treatment of cancer, and to increase the therapeutic effectiveness and safety of cancer therapy, many substances have been looked into as drug carriers. Lipid-based nanoparticles (LBNPs) have significantly attracted interest recently. These natural biomolecules that alternate to other polymers are frequently recycled in medicine due to their amphipathic properties. Lipid nanoparticles typically provide a variety of benefits, including biocompatibility and biodegradability. This review covers different classes of LBNPs, including their characterization and different synthesis technologies. This review discusses the most significant advancements in lipid nanoparticle technology and their use in medicine administration. Moreover, the review also emphasized the applications of lipid nanoparticles that are used in different cancer treatment types.

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Section: Classification Of Lbnpsmentioning

confidence: 99%

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Waheed,

Ali,

Tabassum

et al. 2024

Front. Oncol.

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“…Therefore, research has begun to explore long-acting treatment methods from the perspective of drug development and novel drug delivery systems to prolong treatment efficacy, reduce treatment frequency, and enhance treatment convenience. [104][105][106] instance, the antibody faricimab, which targets Ang2 and VEGF-A receptors, extends the treatment interval to more than 3 months. [107] Simultaneously, the introduction of gene therapy has provided a new perspective on the treatment of DME.…”

Section: Emerging Research Areasmentioning

confidence: 99%

Global research trends and future directions in diabetic macular edema research: A bibliometric and visualized analysis

Li,

Jie,

Wang

et al. 2024

Medicine

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Background: Diabetic Macular Edema (DME) significantly impairs vision in diabetics, with varied patient responses to current treatments like anti-vascular endothelial growth factor (VEGF) therapy underscoring the necessity for continued research into more effective strategies. This study aims to evaluate global research trends and identify emerging frontiers in DME to guide future research and clinical management. Methods: A qualitative and quantitative analysis of publications related to diabetic macular edema retrieved from the Web of Science Core Collection (WoSCC) between its inception and September 4, 2023, was conducted. Microsoft Excel, CiteSpace, VOSviewer, Bibliometrix Package, and Tableau were used for the bibliometric analysis and visualization. This encompasses an examination of the overall distribution of annual output, major countries, regions, institutions, authors, core journals, co-cited references, and keyword analyses. Results: Overall, 5624 publications were analyzed, indicating an increasing trend in DME research. The United States was identified as the leading country in DME research, with the highest h-index of 135 and 91,841 citations. Francesco Bandello emerged as the most prolific author with 97 publications. Neil M. Bressler has the highest h-index and highest total citation count of 46 and 9692, respectively. The journals “Retina – the Journal of Retinal and Vitreous Diseases” and “Ophthalmology” were highlighted as the most prominent in this field. “Retina” leads with 354 publications, a citation count of 11,872, and an h-index of 59. Meanwhile, “Ophthalmology” stands out with the highest overall citation count of 31,558 and the highest h-index of 90. The primary research focal points in diabetic macular edema included “prevalence and risk factors,” “pathological mechanisms,” “imaging modalities,” “treatment strategies,” and “clinical trials.” Emerging research areas encompassed “deep learning and artificial intelligence,” “novel treatment modalities,” and “biomarkers.” Conclusion: Our bibliometric analysis delineates the leading role of the United States in DME research. We identified current research hotspots, including epidemiological studies, pathophysiological mechanisms, imaging advancements, and treatment innovations. Emerging trends, such as the integration of artificial intelligence and novel therapeutic approaches, highlight future directions. These insights underscore the importance of collaborative and interdisciplinary approaches in advancing DME research and clinical management.

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“…1. Novel therapeutic strategies have been designed to optimize efficacy, minimize adverse events, and minimize the frequency of interventions [32,33]. Because VEGF and its receptor, VEGFR, play key roles in the pathogenesis of CNV and RVO [34][35][36][37].…”

Section: Fundus Neovascular Diseases and Their Treatmentmentioning

confidence: 99%

Multifunctional nano-in-micro delivery systems for targeted therapy in fundus neovascularization diseases

Liu,

Huang,

Zhang

et al. 2024

J Nanobiotechnol

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Fundus neovascularization diseases are a series of blinding eye diseases that seriously impair vision worldwide. Currently, the means of treating these diseases in clinical practice are continuously evolving and have rapidly revolutionized treatment opinions. However, key issues such as inadequate treatment effectiveness, high rates of recurrence, and poor patient compliance still need to be urgently addressed. Multifunctional nanomedicine can specifically respond to both endogenous and exogenous microenvironments, effectively deliver drugs to specific targets and participate in activities such as biological imaging and the detection of small molecules. Nano-in-micro (NIM) delivery systems such as metal, metal oxide and up-conversion nanoparticles (NPs), quantum dots, and carbon materials, have shown certain advantages in overcoming the presence of physiological barriers within the eyeball and are widely used in the treatment of ophthalmic diseases. Few studies, however, have evaluated the efficacy of NIM delivery systems in treating fundus neovascular diseases (FNDs). The present study describes the main clinical treatment strategies and the adverse events associated with the treatment of FNDs with NIM delivery systems and summarizes the anatomical obstacles that must be overcome. In this review, we wish to highlight the principle of intraocular microenvironment normalization, aiming to provide a more rational approach for designing new NIM delivery systems to treat specific FNDs. Graphical Abstract

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Long-acting formulation strategies for protein and peptide delivery in the treatment of PSED

Cited by 9 publications

References 312 publications

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Global research trends and future directions in diabetic macular edema research: A bibliometric and visualized analysis

Multifunctional nano-in-micro delivery systems for targeted therapy in fundus neovascularization diseases

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