Long Acting Delivery Systems for Narcotic Antagonists II: Release Rates of Naltrexone from Poly(lactic Acid) Composites

Yolles, S.; Leafe, Thomas D.; Woodland, J.H.R.; Meyer, Francis J.

doi:10.1002/jps.2600640239

Cited by 58 publications

(14 citation statements)

References 2 publications

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“…The first use of PLA films in biomedical applications was reported by Yolles and Colleagues [75,76] for slow release of narcotic antagonists. PLA and PLA blends have been employed to cast films using a variety of techniques with or without the use of solvents.…”

Section: Filmsmentioning

confidence: 98%

Poly(lactic acid) blends in biomedical applications

Saini

Arora

Kumar

2016

Advanced Drug Delivery Reviews

423

258

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Section: Filmsmentioning

confidence: 98%

Poly(lactic acid) blends in biomedical applications

Saini

Arora

Kumar

2016

Advanced Drug Delivery Reviews

423

258

View full text Add to dashboard Cite

“…12 However, various drawbacks have limited its further application. First, the emulsion method has to be used in particle preparation due to the hydrophobicity of PLA, where a relatively large amount of organic solvent (eg, chloroform, dichloromethane) and surfactant are added.…”

Section: Introductionmentioning

confidence: 99%

Novel PEG-graft-PLA nanoparticles with the potential for encapsulation and controlled release of hydrophobic and hydrophilic medications in aqueous medium

Wang¹,

Jiang²,

Yan³

et al. 2011

IJN

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This study concerns the encapsulation and controlled release of both hydrophobic and hydrophilic medications with one polymer, which are delivered together as a combined therapy to treat diseased tissue. To test our hypothesis that the novel PEG-graft-PLA (PEG, polyethylene glycol; PLA, polylactic acid) can deliver both the hydrophobic and hydrophilic medications on account of its amphiphility, charge, and graft structure, PEG-graft-PLA (molecular weight of PEG = 1900) with very low critical micelle concentration was synthesized. One hydrophilic (insulin) and one hydrophobic (naproxen) model medication were loaded in separately during its self-assembly in aqueous solution. The resulting nanoparticles (NPs) were narrowly distributed and spherical, with average particle size around 200 nm, zeta potential >−10 mV, and encapsulation efficiency >50%. The NPs realized controlled release of insulin and naproxen for over 24 and 160 hours, respectively. Specifically, the bioactivity of the insulin released from the NPs was maintained. Owing to encapsulation, both for hydrophobic and hydrophilic medicines, and NPs obtained with similar size and zeta potential, as well as maintenance of bioactivity of loaded protein, we expect the applications of PEG-graft-PLA NPs in combination therapy.

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“…6) In this study the lipophilic drugs were made aqueous soluble by dissolving in a mixture containing ethanol and water then further proceeded with multiple emulsion solvent evaporation method, the method is most successful with drugs which are insoluble or poorly soluble in aqueous medium. 8,9) Many types of drugs with different physical and chemical properties have been formulated into polymeric systems, including anti cancer drugs, 10,11) narcotic agents, 12,13) local anaesthetics, 14) steroids 15,16) and fertility control agents 17,18) using solvent evaporation method of microencapsulation.…”

mentioning

confidence: 99%

Influence of Manufacturing Parameters on Development of Contraceptive Steroid Loaded Injectable Microspheres

2004

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The main objective of this work was to develop a system consisting of polymeric microspheres loaded with steroid drugs. The drugs were encapsulated using biodegradable poly(lactide-co-glycolide) (PLG) and poly(e ecaprolactone) (PCL) by double emulsion solvent evaporation method. The lipophilic drugs, levonorgestrel and ethinylestradiol were made soluble by adding ethanol/water mixture. The effects of parameters like polymer concentration and stabilizer concentration were studied on the size, size distribution, surface properties and loading efficiencies of microspheres. The formulated microspheres were smooth, spherical and uniform in shape and size. Fourier transformed infrared spectroscopy and differential scanning calorimetry studies seemed to confirm the absence of chemical interaction between the drugs and the polymers, while the drugs were dispersed in the polymer. The increase in polymer concentrations increased the size as well as the loading efficiency of microspheres. Data obtained in this study demonstrated that the PLG/PCL microspheres may be a suitable polymeric carrier for long acting injectable drug delivery.

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Long Acting Delivery Systems for Narcotic Antagonists II: Release Rates of Naltrexone from Poly(lactic Acid) Composites

Cited by 58 publications

References 2 publications

Poly(lactic acid) blends in biomedical applications

Poly(lactic acid) blends in biomedical applications

Novel PEG-graft-PLA nanoparticles with the potential for encapsulation and controlled release of hydrophobic and hydrophilic medications in aqueous medium

Influence of Manufacturing Parameters on Development of Contraceptive Steroid Loaded Injectable Microspheres

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