1975
DOI: 10.1002/jps.2600640239
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Long Acting Delivery Systems for Narcotic Antagonists II: Release Rates of Naltrexone from Poly(lactic Acid) Composites

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Cited by 58 publications
(14 citation statements)
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“…The first use of PLA films in biomedical applications was reported by Yolles and Colleagues [75,76] for slow release of narcotic antagonists. PLA and PLA blends have been employed to cast films using a variety of techniques with or without the use of solvents.…”
Section: Filmsmentioning
confidence: 98%
“…The first use of PLA films in biomedical applications was reported by Yolles and Colleagues [75,76] for slow release of narcotic antagonists. PLA and PLA blends have been employed to cast films using a variety of techniques with or without the use of solvents.…”
Section: Filmsmentioning
confidence: 98%
“…12 However, various drawbacks have limited its further application. First, the emulsion method has to be used in particle preparation due to the hydrophobicity of PLA, where a relatively large amount of organic solvent (eg, chloroform, dichloromethane) and surfactant are added.…”
Section: Introductionmentioning
confidence: 99%
“…6) In this study the lipophilic drugs were made aqueous soluble by dissolving in a mixture containing ethanol and water then further proceeded with multiple emulsion solvent evaporation method, the method is most successful with drugs which are insoluble or poorly soluble in aqueous medium. 8,9) Many types of drugs with different physical and chemical properties have been formulated into polymeric systems, including anti cancer drugs, 10,11) narcotic agents, 12,13) local anaesthetics, 14) steroids 15,16) and fertility control agents 17,18) using solvent evaporation method of microencapsulation.…”
mentioning
confidence: 99%