Long-acting contraceptive agents: Analysis and purification of steroid esters

Matlin, Stephen A.; Chan, Lam; Hadjigeogiou, Panikos; Prazeres, M. A.; Mehani, Shahrokh; Roshdi, Samiha

doi:10.1016/0039-128x(83)90107-1

Cited by 12 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The samples were detected at 254 nm, the detector response being linear for the MPA concentrations from 50 to 150 ~tg/ml. In [67], the HPLC analysis of norethisterone and levonorgestrel esters was preceded by purification on preparative HPLC column (at a sample purity of 99.5%). Determination of norgestrel and some accompanying steroidal hormones in [66] was performed on a LiChrospher 100 RP-18 column using a methanol-water mobile phase and a UV detector operated at 254 and 212 nm.…”

Section: Liquid Chromatography and Hplcmentioning

confidence: 99%

Methods of control and standardization of drugs containing progestogen hormones (A review)

et al. 1998

View full text Add to dashboard Cite

The group of progestogen hormones includes progesterone (corpus luteum hormone) and a number of synthetic preparations with a structure close to that of progesterone (norethisterone, lynestrenol, levonorgestrel, desogestrel, etc.).The process of state control of the commercial progestogen hormonal preparations and the corresponding normative documentation are not free of significant drawbacks (in particular, some documents operative in the Russian Federation do not regulate the contents of related steroids). For this reason, the problems pertaining to the increase in the level of standardization and control of the quality of progestogen hormonal preparations require permanent attention and thorough consideration.A lot of information concerning the analysis of progestogen hormones is contained in the monograph of G6rrg [1]. However, there are some new data accumulated since that publication.The main methods used for the analysis of progesterone and related drugs were reviewed in [2].An analysis of the published data shows that the authenticity of ethisterone [3][4][5], norethisterone [4,5], and hydroxyprogesterone capronate [5] is established using a color reaction with sulfuric acid; levonorgestrel is identified by its reaction with m-dinitrobenzene in alkaline medium [5]; ethis-I State Research Institute of Drug Standardization and Control, Ministry of Health and Medical Industry, Moscow, Russia.

show abstract

Section: Liquid Chromatography and Hplcmentioning

confidence: 99%

Methods of control and standardization of drugs containing progestogen hormones (A review)

et al. 1998

View full text Add to dashboard Cite

show abstract

Chemistry for Development

Matlin¹,

Abegaz

2011

The Chemical Element

View full text Add to dashboard Cite

Preparative HPLC. Part 1: A comparison of three types of equipment for the purification of steroids

Matlin

Chan

1984

J. High Resol. Chromatogr.

View full text Add to dashboard Cite

Two commercial preparative liquid chroniatographs have been evaluated for gram-scale purification of steroid esters. The Jobin-Yvon and Waters chromatographs both allow fast separations. Neither system has a high intrinsic column efficiency, but the resolving power of the Waters system can be increased by the use of recycle. A laboratory-assembled preparative liquid chromatograph is described which is ecconomical both in construction and operation, versatile, and considerably more efficient than the two commercial alternatives for single runs on up to a gram scale.

show abstract

Long-acting contraceptive agents: Analysis and purification of steroid esters

Cited by 12 publications

References 6 publications

Methods of control and standardization of drugs containing progestogen hormones (A review)

Methods of control and standardization of drugs containing progestogen hormones (A review)

Chemistry for Development

Preparative HPLC. Part 1: A comparison of three types of equipment for the purification of steroids

Contact Info

Product

Resources

About