Lone Atrial Fibrillation in Elderly Persons

Kopecky, Stephen L.; Gersh, Bernard J.; McGoon, Michael D.; Chu, Chu-Pin; Ilstrup, Duane M.; Chesebro, James H.; Whisnant, Jack P.

doi:10.1001/archinte.159.10.1118

Cited by 89 publications

(33 citation statements)

References 29 publications

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“…Although the prognosis of lone AF is generally considered favorable, the risk of cerebrovas-JCS Guidelines for Pharmacotherapy of AF cular disorder increases especially in patients over 60 years of age. 70 It has been suggested that being up to 60 years of age should be added to the criteria for diagnosing lone AF. 51 Researchers have maintained that the term "lone AF" should not be used since underlying conditions contributing to the development of lone AF may be clarified in the future.…”

Section: Lone Afmentioning

confidence: 99%

Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2013)

2014

Circ J

380

130

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Section: Lone Afmentioning

confidence: 99%

Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2013)

2014

Circ J

380

130

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“…Although the prognosis of lone AF is generally considered favorable, the risk of cerebrovascular disorder in patients with it is high 77 and the incidence of cerebrovascular disorder increases in patients over 60 years of age. 78 It has been suggested that being up to 60 years of age should be added to the criteria for diagnosing lone AF. 6, 79 The percentage of patients with lone AF among those with AF has ranged between 2.1 to 32% in various studies.…”

Section: Af During Pregnancymentioning

confidence: 99%

Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008) - Digest Version -

Group¹

2010

Circ J

122

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“…Without antithrombotic therapy, the rate varies from fewer than 2 to more than 10 strokes per 100 patient-years. [1][2][3][4][5][6][7] Although adjusted-dose warfarin is superior to aspirin for reducing stroke in AF patients, the absolute risk reduction is determined by the stroke risk with aspirin therapy. 8,9 Thus, quantifying the risk of stroke is crucial for determining which AF patients would benefit most from warfarin therapy.…”

mentioning

confidence: 99%

Selecting Patients With Atrial Fibrillation for Anticoagulation

et al. 2004

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Background— The rate of stroke in atrial fibrillation (AF) depends on the presence of comorbid conditions and the use of antithrombotic therapy. Although adjusted-dose warfarin is superior to aspirin for reducing stroke in AF, the absolute risk reduction of warfarin depends on the stroke rate with aspirin. This prospective cohort study tested the predictive accuracy of 5 stroke risk stratification schemes. Methods and Results— The study pooled individual data from 2580 participants with nonvalvular AF who were prescribed aspirin in a multicenter trial (Atrial Fibrillation, Aspirin, Anticoagulation I study [AFASAK-1], AFASAK-2, European Atrial Fibrillation Trial, Primary Prevention of Arterial Thromboembolism in patients with nonrheumatic Atrial Fibrillation in primary care study, and Stroke Prevention and Atrial Fibrillation [SPAF]-III high risk or SPAF-III low risk). There were 207 ischemic strokes during 4887 patient-years of aspirin therapy. All schemes predicted stroke better than chance, but the number of patients categorized as low and high risk varied substantially. AF patients with prior cerebral ischemia were classified as high risk by all 5 schemes and had 10.8 strokes per 100 patient-years. The CHADS 2 scheme (an acronym for Congestive heart failure, Hypertension, Age >75, Diabetes mellitus, and prior Stroke or transient ischemic attack) successfully identified primary prevention patients who were at high risk of stroke (5.3 strokes per 100 patient-years). In contrast, patients identified as high risk by other schemes had 3.0 to 4.2 strokes per 100 patient-years. Low-risk patients identified by all schemes had 0.5 to 1.4 strokes per 100 patient-years of therapy. Conclusions— Patients with AF who have high and low rates of stroke when given aspirin can be reliably identified, allowing selection of antithrombotic prophylaxis to be individualized.

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Lone Atrial Fibrillation in Elderly Persons

Abstract: Background:The risk of stroke in persons aged 60 years and younger with lone atrial fibrillation (LAF) is no greater than in the general population. The effect of older age on the risk of stroke in persons with LAF is less well established.

Cited by 89 publications

References 29 publications

Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2013)

Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2013)

Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008) - Digest Version -

Selecting Patients With Atrial Fibrillation for Anticoagulation

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