London Hospital.

Luke,

doi:10.1016/s0140-6736(02)53335-3

Cited by 1 publication

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“…In Scopus, the total of cancer-related papers in 2018 was 2,857,590 (see Figure 1a), and CRCrelated papers numbered 167,366 (see Figure 1b); both subjects presented an exponential rise from 1970. The first documents indexed in Scopus related to CRC were report cases of medical interventions; for instance, Mr. Luke (1860) reported the surgery of an intestinal obstruction resulting from CRC [9]. Similarly, Dunphy (1947) reported four cases of CRC and included a gross pathological evaluation of the tumors [10].…”

Section: Scientific-technological Analysismentioning

confidence: 99%

Recent Advances in Polymer Nanomaterials for Drug Delivery of Adjuvants in Colorectal Cancer Treatment: A Scientific-Technological Analysis and Review

et al. 2020

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Colorectal cancer (CRC) is the type with the second highest morbidity. Recently, a great number of bioactive compounds and encapsulation techniques have been developed. Thus, this paper aims to review the drug delivery strategies for chemotherapy adjuvant treatments for CRC, including an initial scientific-technological analysis of the papers and patents related to cancer, CRC, and adjuvant treatments. For 2018, a total of 167,366 cancer-related papers and 306,240 patents were found. Adjuvant treatments represented 39.3% of the total CRC patents, indicating the importance of adjuvants in the prognosis of patients. Chemotherapy adjuvants can be divided into two groups, natural and synthetic (5-fluorouracil and derivatives). Both groups can be encapsulated using polymers. Polymer-based drug delivery systems can be classified according to polymer nature. From those, anionic polymers have garnered the most attention, because they are pH responsive. The use of polymers tailors the desorption profile, improving drug bioavailability and enhancing the local treatment of CRC via oral administration. Finally, it can be concluded that antioxidants are emerging compounds that can complement today’s chemotherapy treatments. In the long term, encapsulated antioxidants will replace synthetic drugs and will play an important role in curing CRC.

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Section: Scientific-technological Analysismentioning

confidence: 99%