Lomaiviticins A and B, Potent Antitumor Antibiotics from Micromonospora lomaivitiensis

Umpolung Reactivity in the Stereoselective Synthesis of S‐Linked 2‐Deoxyglycosides

“…Dedicated to Professor Samuel J. Danishefsky 2-Deoxysugars, especially 2,6-dideoxy-and 2,3,6-trideoxysugars, are an important class of carbohydrates and exist in numerous biologically active natural products and clinical agents, including anthracyclines, [1] angucyclines, [2] aureolic acid antibiotics, [3] avermectins, [4] enediynes, [5] pluramycins, [6] lomaiviticins, [7] vancomycin, [8] and cardiac glycosides.…”

Naturally Occurring Dimers from Chemical Perspective

“…There are also two dimeric diazobenzofluorene glycosides named lomaiviticins A and B (90 and 91, resp.) isolated from a marine ascidian symbiont Micromonospora lomaivitiensis, which exhibit potent DNA-damaging activity [63].…”

A Phosphine‐Mediated Conversion of Azides into Diazo Compounds

“…[1] Diazo compounds are found in nature, examples of which include azaserine [2] and members of the kinamycin [3] and lomaiviticin [4] families of marine natural products. Depending upon their stability and coexisting functional groups, diazo compounds can present a challenge with respect to their preparation and isolation.…”