Lokale Hyperthermie bei Prostataerkrankungen?

Transurethral Microwave Thermotherapy in Symptomatic Benign Prostatic Hyperplasia

“…Results will be presented when a sufficient number of patients are enrolled in the study and when the follow-up period is long enough. Conflicting results have been published about hyper thermia/thermotherapy of the prostate in patients with BPH [12][13][14][15], These reports are difficult to compare because of the differences in patient populations, the dif ferent definitions used for success or failure of the treat ment, and the different machines used.…”

Transurethral Needle Ablation (TUNA): Safety, Feasibility, and Tolerance of a New Office Procedure for Treatment of Benign Prostatic Hyperplasia

“…The TUNA device's low-frequency RF waves (490 kHz) give a deeper penetration and more uniform temperature distribution than microwaves (300-3,000 MHz) and the device is able to create lesions with sharply defined margins using very low power levels of 5-10 W. This is due to a steep temperature gradient from the needle to the periphery of the lesion. Studies show that transurethral microwave therapy produces a temperature gradient of 5-15°C over a few millimeters in the lesion area adjacent to the urethra and 1-20 C/mm near the cap sule [8]. Infrared thermal imaging studies of the TUNA device in a tissue model show a much steeper gradient near the proximal needle of 58°C/mm (the area near the urethra in clinical use) and near the needle tip of 300 C/ mm (the area nearer the capsule in clinical use).…”

Hyperthermia and Thermotherapy of Benign Prostatic Hyperplasia: A Critical Review

“…1). Homogeneous warming of a tumor is best achieved utilizing frequencies of 0.5-1.0 MHz [2], Microwaves are characterized by a shallow inhomogeneous penetration [2], The effect of the waves varies within each tissue depending mainly on the water content and the thermoregulation related to the blood supply.…”

“…Tumor cells are more sensitive to heat than normal cells when the temper ature ranges between 42 and 44 °C [4]. The poor blood supply of neoplastic tissue and the decreased vasodilata tion capacity of the neovascular bed explains the greater effect of a temperature rise on neoplastic cells [5],The destruction of normal cells by heat needs a tem perature threshold above 44-45 °C [2]. One speaks of hyperthermia when the temperature is below 45 °C and of thermotherapy when the temperature lies above 45 °C.…”

“…1). Homogeneous warming of a tumor is best achieved utilizing frequencies of 0.5-1.0 MHz [2], Microwaves are characterized by a shallow inhomogeneous penetration [2], The effect of the waves varies within each tissue depending mainly on the water content and the thermoregulation related to the blood supply.The first effect of heating tissue in cancer was de scribed by Bush in 1866 [3] on a patient with proven sar coma which disappeared completely following a febrile attack caused by erysipelas infection. Tumor cells are more sensitive to heat than normal cells when the temper ature ranges between 42 and 44 °C [4].…”