1973
DOI: 10.5840/schoolman197351170
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"Logic for Philosophers," by Richard L. Purtill

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“…The kinetic aspects of the reaction are currently being studied in our laboratory. The facts that colchicine binds to free tubulin better than to microtubules (Table 2) and did not depolymerize the tubules seems to support the view that the in vivo action of the antimitotic agent is to bind to tubulin and thereby prevent microtubule formation (Borisy and Taylor, 1967;Wilson and Meza, 1973). On the other hand, although the colchicine found in the pellet after centrifugation at 100,000 X g might be due to the presence of tubulin which sedimented, it could also be due to colchicine bound to intact tubules.…”
Section: Discussionmentioning
confidence: 61%
“…The kinetic aspects of the reaction are currently being studied in our laboratory. The facts that colchicine binds to free tubulin better than to microtubules (Table 2) and did not depolymerize the tubules seems to support the view that the in vivo action of the antimitotic agent is to bind to tubulin and thereby prevent microtubule formation (Borisy and Taylor, 1967;Wilson and Meza, 1973). On the other hand, although the colchicine found in the pellet after centrifugation at 100,000 X g might be due to the presence of tubulin which sedimented, it could also be due to colchicine bound to intact tubules.…”
Section: Discussionmentioning
confidence: 61%
“…A number of authors have proposed relationships that predict suspended sediment yield as a function of precipitation, under a variety of climates, namely: semiarid or arid (Fournier, 1949;Langbein and Schumn, 1958); subhumid (Rango, 1970;Wilson, 1973); tropical (Fournier, 1949;Wilson, 1973).…”
Section: Sediment Yield As a Function Of Precipitationmentioning
confidence: 99%