Loganin Inhibits Angiotensin II–Induced Cardiac Hypertrophy Through the JAK2/STAT3 and NF-κB Signaling Pathways

Abstract

Loganin is an iridoid glycoside extracted from Cornus officinalis, which is a traditional oriental medicine, and many biological properties of loganin have been reported. Nevertheless, it is not clear whether loganin has therapeutic effect on cardiovascular diseases. Hence, the aim of the present study was to investigate the effect of loganin on Ang II–induced cardiac hypertrophy. In the present study, we reported for the first time that loganin inhibits Ang II–provoked cardiac hypertrophy and cardiac damages in H9C2 cells and in mice. Furthermore, loganin can achieve cardioprotective effects through attenuating cardiac fibrosis, decreasing pro-inflammatory cytokine secretion, and suppressing the phosphorylation of critical proteins such as JAK2, STAT3, p65, and IκBα. Besides, the outstanding findings of the present study were to prove that loganin has no significant toxicity or side effects on normal cells and organs. Based on these results, we conclude that loganin mitigates Ang II–induced cardiac hypertrophy at least partially through inhibiting the JAK2/STAT3 and NF-κB signaling pathways. Accordingly, the natural product, loganin, might be a novel effective agent for the treatment of cardiac hypertrophy and heart failure.

Rhein ameliorates transverse aortic constriction-induced cardiac hypertrophy via regulating STAT3 and p38 MAPK signaling pathways

“…All cell lines were maintained in a 5% CO 2 humidified cell incubator at 37 °C. The cells were treated with 1 μM angiotensin II (Xu et al, 2021).…”

Development and Validation of a UPLC-MS/MS Method for the Quantification of Components in the Ancient Classical Chinese Medicine Formula of Guyinjian

“…Recently, a study highlighted the protective role of Morroniside against H 2 O 2 -induced damage; further studies suggested that treatment with Morroniside decreased apoptosis, autophagy, and oxidative stress in rat ovarian granulosa cells through the PI3K (phosphatidylinositol 3-kinase)/AKT (serine/threonine-specific protein kinase)/mTOR (mechanistic target of rapamycin) pathway [ 15 ]. According to reports, Loganin mitigates Ang II-induced cardiac hypertrophy, at least partially, through inhibiting the JAK 2 (Janus Kinase 2) / STAT 3 (signal transducers and activators of transduction-3) and NF-κB (Nuclear factor-κB) signaling pathways and might be a novel effective agent for the treatment of cardiac hypertrophy and heart failure [ 16 ]. A quantibody array analysis demonstrated that Polygalaxanthone III downregulates inflammation in lipopolysaccharide-stimulated RAW264.7 macrophages [ 17 ].…”

An Overview of Traditional Uses, Phytochemical Compositions and Biological Activities of Edible Fruits of European and Asian Cornus Species

“…Loganin, one of the most common iridoid glycosides isolated from Cornus species, was recently investigated on angiotensin II-induced cardiac hypertrophy [193]. Angiotensin II is a significant component of the renin-angiotensin system and plays an important role in triggering hypertension and myocardial hypertrophy.…”

“…Inhibition of angiotensin II. Cardioprotective effects through a decrease in pro-inflammatory cytokine secretion, suppression of phosphorylation of critical proteins including STAT3, JAK2, IκBα, and p65, and attenuation of cardiac fibrosis [193][194][195][196][197] Ophthalmic activity…”