Löfgren’s syndrome revisited: a study of 186 patients

Mañá, Juan; Gómez-Vaquero, Carmen; Montero, Abelardo; Salazar, Albert; Marcoval, Joaquim; Valverde, José; Manresa, F.; Pujol, Ramón

doi:10.1016/s0002-9343(99)00223-5

Cited by 231 publications

(104 citation statements)

References 32 publications

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“…Thus, the first condition to diagnose sarcoidosis is to meet a typical or consistent clinical and radiological presentation. While some typical manifestations, such as Löfgren's syndrome [6], Heerfordt's syndrome, and bilateral hilar lymphadenopathy in a patient with uveitis or no clinical manifestation [17,18], are easy to identify. It may be more difficult to specify whether or not other manifestations may be either typical or inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the fact that some presentations may strongly suggest sarcoidosis (e.g. Löfgren's syndrome) [6], typical skin or ocular manifestations can lead to a rapid diagnosis for at least one third of patient symptoms. This may often be nonspecific and have shared associations with more frequent diseases, resulting in a diagnosis that is delayed by months to years [7].…”

Section: Introductionmentioning

confidence: 99%

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Management of sarcoidosis in clinical practice

et al. 2016

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Sarcoidosis is a systemic disease of unknown cause with very diverse presentation, outcome, severity and need for treatments. While some presentations may be very typical, for many patients, the presentation is nonspecific, with shared associations with other diseases at times being by far more frequent or misleading, which can be a cause of significant delay and often several consultations before a diagnosis of sarcoidosis can be confirmed. This is particularly the case when pulmonary manifestations are in the forefront. The diagnosis relies on three well-known criteria. In clinical practice, these criteria are not easily implemented, particularly by physicians without expertise in sarcoidosis, which can lead to a risk of either under-or over-diagnosis. Qualifying the presentation according to sarcoidosis diagnosis is essential. However, it is often not easy to classify the presentation as typical versus compatible or compatible versus inconsistent. Further investigations are needed before any other hypothesis is to be considered. It is important to detect events and to determine whether or not they are indicative of a flare of sarcoidosis. Eventually, treatment needs to be related to the correct indications. The evaluation of the efficacy and safety of treatments is crucial. To address such issues, we present five emblematic cases that illustrate this. @ERSpublications Showing emblematic cases is the best way to illustrate the multiple conditions to deal with for managing sarcoidosis http://ow.ly/10A5Yv

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Management of sarcoidosis in clinical practice

et al. 2016

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“…The most common non-specific lesion is EN which histologically shows septal panniculitis without sarcoidal granuloma. Löfgren's syndrome was first recognized as an acute and benign subtype of sarcoidosis, which usually presents the symptoms of EN, acute polyarthritis and bilateral hilar lymphadenopathy [3]. It is currently considered as a variant of sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis presenting erythema nodosum-like lesions: report of two cases

Nakamura-Wakatsuki¹,

Yamamoto²

2013

Our Dermatol Online

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Introduction: Sarcoidosis is a systemic non-infectious granulomatous disorder which exhibits various specific and non-specific cutaneous manifestations. Erythema nodosum-like eruption is a rare specific lesion associated with sarcoidosis, which histologically shows noncaseating epithelioid granuloma. It is suggested that this type is frequently associated with ocular sarcoidosis. Main observations: We describe two Japanese cases presenting with erythema nodosum-like eruptions on the lower legs, which histologically showed sarcoidal granuloma. The tenderness of erythema nodosum-like eruption is milder than that of non-specific erythema nodosum. Lung involvement was observed in both cases, and ocular involvement was seen in one of them. Conclusions: Because of the high frequency of extra-cutaneous involvement, we should carry out skin biopsies to reveal specific sarcoidal granulomas appropriately and follow up patients with erythema nodosum-like eruption carefully.

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“…There is increasing evidence that genetics play an important role in the pathogenesis, and certain HLA subtypes are associated with disease risk as well as clinical phenotype. In pulmonary sarcoidosis, T-cell lymphocytic alveolitis precedes the histologic finding of non-necrotizing or non-caseating granulomas (although 5-10% may show areas of focal necrosis) [6]. Sarcoidosis is a diagnosis of exclusion and requires both a consistent clinical presentation and histologic confirmation of granulomatous inflammation.…”

Section: Pathophysiology Of Pulmonary Sarcoidosismentioning

confidence: 99%

Pulmonary function testing and sarcoidosis: A review

W¹

2018

Lung Breath J

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Sarcoidosis is a granulomatous disease of unknown etiology that can affect any organ. Identification of sarcoidosis patients is key to improving their outcomes and reducing health care costs. Unfortunately, diagnosis can be complex and require significant testing. Pulmonary function testing (PFT), along with chest imaging, is often the initial testing obtained by the respiratory physician in evaluation of the patient with dyspnea and is often used to monitor response to therapy. PFTs are one of many potentially useful tools when following patients with pulmonary sarcoidosis. The goal of this review is to discuss the patterns and pitfalls of PFT interpretation in patients with sarcoidosis.

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Löfgren’s syndrome revisited: a study of 186 patients

Cited by 231 publications

References 32 publications

Management of sarcoidosis in clinical practice

Management of sarcoidosis in clinical practice

Sarcoidosis presenting erythema nodosum-like lesions: report of two cases

Pulmonary function testing and sarcoidosis: A review

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