Lofexidine, a Clonidine Analogue Effective in Opiate Withdrawal

Washton, Arnold M.; Resnick, Richard B.; J, Perzel; J, Garwood; Ms, Gold; Pottash, A. Carter; Annitto, WilliamJ.; Extein, Irl; Kleber, HerbertD.

doi:10.1016/s0140-6736(81)91747-5

Cited by 23 publications

(3 citation statements)

References 11 publications

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“…However, another alpha-2 agonist, lofexidine, is said by clinicians not to cause the same degree of sedation as clonidine, when used in opiate withdrawal (Washton et at., 1981;Gold et al, 1981).…”

Section: Specificity Of Effectmentioning

confidence: 99%

Preliminary studies of clonidine in psychotic patients

Angrist

Smith

Adler

et al. 1988

J. Neural Transmission

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Twelve psychotic patients received a mean dose of 3.3 mg/day of clonidine. In four clonidine was the only treatment and in the remaining eight clonidine was superadded to a neuroleptic regimen after symptomatology was stable. Clonidine caused reduction of scores for both productive psychotic symptoms and anxiety. Negative symptoms were unaffected. These findings are discussed with respect to the small magnitude of the effects, questions as to specificity of the effects and methodologic limitations of this pilot study.

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Section: Specificity Of Effectmentioning

confidence: 99%

Preliminary studies of clonidine in psychotic patients

Angrist

Smith

Adler

et al. 1988

J. Neural Transmission

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“…The clonidine cogener lofexidine is another a2 agonist alternative to clonidine that is useful in detoxification, but is not yet commercially available. 14 Like clonidine, guanabenz reduces central noradrenergic output. 15 Therefore, successful use of guanabenz supports the theory that central adrenergic hyperactivity, mediated by the locus ceruleus, generates the symptoms of the narcotic withdrawal syndrorne.v' The relative lack of side effects and improved control of narcotic abstinence symptoms in this patient could be due to the highly specific a2 binding of guanabenz claimed by the manufacturer.9.16R eferences EXTRACTO Un hombre de 29 aiios que ingeria aproximadamente 1000 mg de codeina diarios, 0 su equivalente narcotico, por espacio de siete aiios fue sometido a tratarniento de detoxificaci6n con c1onidina.…”

Section: Case Reportmentioning

confidence: 99%

Guanabenz Therapy for Opiate Withdrawal

Mulry¹

1985

Drug Intelligence & Clinical Pharmacy

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A 29-year-old man used codeine approximately 1000 mg/d for seven years prior to detoxification. He developed dose-related clonidine side effects of dizziness, sedation, and dysphoria during standard clonidine detoxification; however, opiate withdrawal symptoms persisted. Conversion to guanabenz, a clonidine-like alpha 2 agonist, promptly relieved the opiate withdrawal symptoms without side effect recurrence. Guanabenz shows promise as an opiate withdrawal agent.

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“…opioid-dependent patients by Washton et al in 1981[46]. It was approved for use in opioid detoxification in the United Kingdom, most of the European Union, and other countries in the 1980s and 1990s.…”

mentioning

confidence: 99%

Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine

Raffa¹,

Pergolizzi²,

Taylor³

et al. 2019

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Lucemyra® (lofexidine hydrochloride) has recently been approved by the US FDA for the mitigation of withdrawal symptoms to facilitate abrupt discontinuation of opioids in adults. Lofexidine is an alpha-2 adrenoceptor agonist. However, the clinical attributes of lofexidine differ in advantageous ways from the classical alpha-2 adrenoceptor agonist clonidine. In the present study, we measured the receptor binding profile of lofexidine and clonidine in an effort to gain an insight into the clinical difference(s).

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Lofexidine, a Clonidine Analogue Effective in Opiate Withdrawal

Cited by 23 publications

References 11 publications

Preliminary studies of clonidine in psychotic patients

Preliminary studies of clonidine in psychotic patients

Guanabenz Therapy for Opiate Withdrawal

Differences in the Receptor Binding Profile of Lofexidine Compared to Clonidine

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