Loeffler's Endocarditis: A Diagnosis Made With Cardiac Magnetic Resonance (Cmr) Imaging

Park, Jeffrey; Hemu, Mohamad; Kalra, Dinesh

doi:10.1016/s0735-1097(19)32873-6

Cited by 12 publications

(4 citation statements)

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“…Our patient presented with congestive cardiac failure and like many previously reported cases, he was in his 6th to 7th decade of life [10] , [11] , [12] , [13] , [14] , [15] , [16] . He was unusual in having greater right-sided myocardial involvement, as most cases of hypereosinophillic cardiomyopathy have reportedly greater involvement of the LV apical endocardium, leading to diastolic impairment [11 , 15 , 16] . However, cases of RV involvement affecting the apex and conducting system have been reported in literature, but there is no specific figure for incidence [12] , [13] , [14] .…”

Section: Discussionsupporting

confidence: 72%

Right sided heart failure secondary to hypereosinophilic cardiomyopathy – clinical manifestation and diagnostic pathway

Ramtoola

Shahzad

Okonkwo

et al. 2020

Radiology Case Reports

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Hypereosinophilic cardiomyopathy is a rare restrictive cardiomyopathy which often presents with left-sided heart failure. We present an interesting case of a 58-year-old male patient with known hypereosinophillic syndrome who had presented with congestive cardiac failure with predominant features of right-sided volume overload. Cardiac magnetic resonance imaging confirmed the diagnosis by demonstrating obliteration of the right ventricular apex and endocardial-delayed gadolinium enhancement at the mid-septal and inferior segment, at both the right ventricular and left ventricular apical region, consistent with fibrosis. He was successfully treated with intravenous diuretics to good effect. This case report demonstrates a rare clinical presentation of right ventricle involvement in hypereosinophilic cardiomyopathy and the current pathway for diagnosis with the favoured emergence of cardiac magnetic resonance imaging. All patients with hypereosinophilic syndrome should be closely monitored for signs of cardiac involvement, as early treatment carries a better prognosis.

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Section: Discussionsupporting

confidence: 72%

Right sided heart failure secondary to hypereosinophilic cardiomyopathy – clinical manifestation and diagnostic pathway

Ramtoola

Shahzad

Okonkwo

et al. 2020

Radiology Case Reports

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“…The imaging features and the presence of hypereosinophilia were consistent with the diagnosis of Loeffler endocarditis [ 1 , 2 ]. A coronary angio-computed tomography was performed, showing no significant coronary stenosis, a myocardial bridge in the mid-segment of the left anterior descendant artery, and a coronary calcium score of 0.…”

mentioning

confidence: 80%

“…Cardiovascular imaging plays a pivotal role in the diagnosis [ 2 , 4 , 5 ]. While echocardiography features are usually most obvious in the late stages of the disease and may provide insufficient details, cardiac magnetic resonance imaging may be used to identify early changes and to better characterize the endocardium and the presence of thrombus in the late stages [ 6 , 7 , 8 ].…”

mentioning

confidence: 99%

Loeffler Endocarditis Causing Heart Failure with Preserved Ejection Fraction (HFpEF): Characteristic Images and Diagnostic Pathway

2022

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We report the case of a 69-year-old female patient in which echocardiography and cardiac magnetic resonance imaging were used to diagnose a patient presenting with heart failure with preserved ejection fraction (HFpEF) due to Loeffler endocarditis. Loeffler endocarditis is an uncommon cause of heart failure with preserved ejection fraction, triggered by eosinophil and lymphocyte infiltration of the endomyocardium, followed by the formation of thrombus in the afflicted area, and eventually fibrosis. This condition is due to an increased number of eosinophils associated with allergies, infections, systemic conditions, as well as malignancies and hypereosinophilic syndrome. Loeffler endocarditis can lead to serious complications, such as progressive heart failure, systemic thromboembolic events, or arrhythmias (including sudden cardiac death).

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“…Cardiovascular imaging plays a key role in the diagnosis of Loeffler endocarditis. 8 , 56 , 57 The choice of imaging techniques employed to diagnose Loeffler endocarditis evolves in tandem with the advancement of the disorder. Multimodal imaging is preferred due to its comprehensive and complementary nature.…”

Section: Diagnosis Of Loeffler Endocarditismentioning

confidence: 99%

In-Depth Review of Loeffler Endocarditis: What Have We Learned?

Su,

Liang,

Lü

et al. 2024

JIR

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Loeffler endocarditis, eosinophilic endocarditis or eosinophilic endomyocardial disease are conditions associated with hypereosinophilia and they affect the heart function. Loeffler endocarditis is a rare endomyocardial disorder thought to be caused by eosinophilic damage. The disorder is characterized by inflammatory infiltration, formation of thrombus within cardiovascular system, and ultimately fibrosis of the afflicted area. It can lead to multiple severe complications, including thromboembolic disease, thickening of fibrous tissue in the endocardium of ventricles, valve involvement, apical obliteration, and various heart disorders. Although early clinical intervention can lead to remission, the underlying mechanisms of the disorder remain unresolved. In the present article, we summarise the existing literature concerning Loeffler endocarditis based on PubMed, Web of Science, and other medical databases to conduct an in-depth review of the epidemiology, etiology, pathophysiological mechanisms, staging, diagnosis, treatment and prognosis of Loeffler endocarditis. Meanwhile, we provide novel patients data and clinical figures of Loeffler endocarditis to supplement the understanding of this cardiac disorder. The findings presented in this article provide a basis for further studies and can be used to improve management of the disorder.

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Loeffler's Endocarditis: A Diagnosis Made With Cardiac Magnetic Resonance (Cmr) Imaging

Cited by 12 publications

References 0 publications

Right sided heart failure secondary to hypereosinophilic cardiomyopathy – clinical manifestation and diagnostic pathway

Right sided heart failure secondary to hypereosinophilic cardiomyopathy – clinical manifestation and diagnostic pathway

Loeffler Endocarditis Causing Heart Failure with Preserved Ejection Fraction (HFpEF): Characteristic Images and Diagnostic Pathway

In-Depth Review of Loeffler Endocarditis: What Have We Learned?

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