Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction

Dai, Zhong-hua; Liu, Ying; Nie, Li-na; Chen, Weiqi; Xu, X.; Li, Yonghui; 张, 建军; Shen, Fang; Song, Nan; Liang, Jing

doi:10.1038/s41386-022-01477-0

Cited by 6 publications

(3 citation statements)

References 91 publications

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“… 33 In terms of addiction memory, engram cells have been identified in several brain regions, such as drug reward memory engram cells located in ventral CA1, nucleus accumbens core (NAcC) and anterior limbic cortex, 19 , 34 and drug withdrawal memory engram cells located in the dentate gyrus and nucleus accumbens. 35 , 36 However, as far as the BLA is concerned, there is still a lack of studies showing the presence of drug withdrawal memory engram cells in this region of the brain. To study how MEC -BLA neurons participate in context-induced retrieval of morphine withdrawal memory, firstly, we examined whether there were drug withdrawal memory engram cells in the BLA and then examined the influence of the inhibition of MEC −BLA neurons, using chemogenetic method, on context-induced reactivation of morphine withdrawal memory engram cells of the BLA.…”

Section: Discussionmentioning

confidence: 99%

Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory

Fu,

Cao,

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory

Fu,

Cao,

et al. 2024

iScience

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“…Multiple recent studies, including our own yet-to-be-published findings, have endeavored to manipulate hippocampal-dependent contextual memory by activating LC-hippocampus pathways to promote cognitive and behavioral flexibility that might be compromised in certain models associated with severe/chronic stress or repeated drug use during periods of new learning. For instance, the LC is implicated during early extinction, and optical activation of LC to DG projection neurons just before administering a recall-extinction procedure in morphine-dependent mice, resulted in enhanced extinction ( Dai et al, 2023 ). We are also currently exploring the role of LC activation on fear memory reconsolidation ( Asgarali et al, 2023 ) and the enhancement of extinction learning.…”

Section: Concluding Perspectives and Future Research Directionsmentioning

confidence: 99%

Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus

Grella,

Donaldson

2024

Front. Mol. Neurosci.

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Here, we review the basis of contextual memory at a conceptual and cellular level. We begin with an overview of the philosophical foundations of traversing space, followed by theories covering the material bases of contextual representations in the hippocampus (engrams), exploring functional characteristics of the cells and subfields within. Next, we explore various methodological approaches for investigating contextual memory engrams, emphasizing plasticity mechanisms. This leads us to discuss the role of neuromodulatory inputs in governing these dynamic changes. We then outline a recent hypothesis involving noradrenergic and dopaminergic projections from the locus coeruleus (LC) to different subregions of the hippocampus, in sculpting contextual representations, giving a brief description of the neuroanatomical and physiological properties of the LC. Finally, we examine how activity in the LC influences contextual memory processes through synaptic plasticity mechanisms to alter hippocampal engrams. Overall, we find that phasic activation of the LC plays an important role in promoting new learning and altering mnemonic processes at the behavioral and cellular level through the neuromodulatory influence of NE/DA in the hippocampus. These findings may provide insight into mechanisms of hippocampal remapping and memory updating, memory processes that are potentially dysregulated in certain psychiatric and neurodegenerative disorders.

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“…One of the challenges faced in understanding memory is how to visualize and capture the ever-changing memory traces in the brain at the cellular level. In this regard, the concept of engram cells provided scientists with a meaningful target to study memory (Buhusi and Buhusi, 2023 ; Dai et al, 2023 ; Gall et al, 2023 ; Ghandour and Inokuchi, 2023 ; Hammack et al, 2023 ; Jung et al, 2023 ; Kenna et al, 2023 ; Lee C. et al, 2023 ; Mohanta et al, 2023 ; Nomoto et al, 2023 ; Okray et al, 2023 ; Osanai et al, 2023 ; Park et al, 2023 ; Rahsepar et al, 2023 ; Schott, 2023 ; Terranova et al, 2023 ; Wilmerding et al, 2023 ). In the 1950's, certain scientists could not identify engram cells due to a lack of technology (Lashley, 1931 , 1950 , 1963 ).…”

Section: Introductionmentioning

confidence: 99%

Exploring the memory: existing activity-dependent tools to tag and manipulate engram cells

Pang,

Wu,

Chen

et al. 2024

Front. Cell. Neurosci.

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The theory of engrams, proposed several years ago, is highly crucial to understanding the progress of memory. Although it significantly contributes to identifying new treatments for cognitive disorders, it is limited by a lack of technology. Several scientists have attempted to validate this theory but failed. With the increasing availability of activity-dependent tools, several researchers have found traces of engram cells. Activity-dependent tools are based on the mechanisms underlying neuronal activity and use a combination of emerging molecular biological and genetic technology. Scientists have used these tools to tag and manipulate engram neurons and identified numerous internal connections between engram neurons and memory. In this review, we provide the background, principles, and selected examples of applications of existing activity-dependent tools. Using a combination of traditional definitions and concepts of engram cells, we discuss the applications and limitations of these tools and propose certain developmental directions to further explore the functions of engram cells.

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Locus coeruleus input-modulated reactivation of dentate gyrus opioid-withdrawal engrams promotes extinction

Cited by 6 publications

References 91 publications

Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory

Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory

Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus

Exploring the memory: existing activity-dependent tools to tag and manipulate engram cells

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