Locoregional recurrence of triple‐negative breast cancer after breast‐conserving surgery and radiation

Abstract

BACKGROUND:The results of radiation on the local control of triple receptor‐negative breast cancer (negative estrogen [ER], progesterone [PR], and HER‐2/neu receptors) was studied.METHODS:Conservative surgery and radiation were used in 753 patients with T1‐T2 breast cancer. Three groups were defined by receptor status: Group 1: ER or PR (+); Group 2: ER and PR (−) but HER‐2 (+); and Group 3: triple‐negative (TN). Factors analyzed were age, menopausal status, race, stage, tumor size, lymph node status, presentation, grade, extensive in situ disease, margins, and systemic therapy. The primary endpoint was 5‐year locoregional recurrence (LRR) isolated or total with distant metastases.RESULTS:ER‐ and PR‐negative patients were statistically significantly more likely to be black, have T2 disease, have tumors detectable on both mammography and physical examination, have grade 3 tumors, and receive chemotherapy. There were no significant differences noted with regard to ER− and PR− patients by HER‐2 status. There was a significant difference noted in rates of first distant metastases (3%, 12%, and 7% for Groups 1, 2, and 3, respectively; P = .009). However, the isolated 5‐year LRR was not significantly different (2.3%, 4.6%, and 3.2%, respectively; P = .36) between the 3 groups.CONCLUSIONS:Patients with TN breast cancer do not appear to be at a significantly increased risk for isolated LRR at 5 years and therefore remain appropriate candidates for breast conservation. Cancer 2009. © 2009 American Cancer Society.

Outcomes of Triple-Negative Versus Non-Triple-Negative Breast Cancers Managed with Breast-Conserving Therapy

“…Nguyen et al (2008) also showed a higher local recurrence rate of 7% in triple negative group when compared with recurrence rates for luminal type A (0.8%) and type B (1.5%) subgroups. Variable results were reported in other studies on TNBC managed with BCT (Nguyen et al, 2008;Freedman et al, 2009;Miller et al, 2009;Voduc et al, 2010). In a recent meta-analysis, Lowery et al (2012) included 12, 592 patients from 15 studies who either received BCT (n=7176) or mastectomy (n=5416).…”

Triple-negative breast cancer in Hispanic patients

“…Studies have reported similar results for CSS and a high LRR rate among patients with TNBC. [51][52][53][54][55] Although there are no population-based cancer registries in Mexico, there are some estimates of breast cancer incidence through mortality-specific analyses. On the basis of these findings, the estimated incidence of breast cancer in our country is of 27.2 per 100,000 with a mortality rate of 10.1 per 100,000.…”

New Criteria to Predict Tumor Recurrence in Invasive Ductal Carcinoma of the Breast

“…14 Although loco-regional recurrence, in addition to occurrence of distant metastasis, is known to be more frequent in patients with TNBC, 15,16 the property in application of sentinel lymph node dissection has been discussed insufficiently, 17 and a breast-preserving operation has not been considered as a contraindication for TNBC. 15,18 Tumor recurrence of TNBC has been reported to rapidly increase within 2 years after treatment and to gradually decrease thereafter, and the risk of recurrence and/or death in TNBC is generally low 5 years after initial diagnosis.…”

“…15,18 Tumor recurrence of TNBC has been reported to rapidly increase within 2 years after treatment and to gradually decrease thereafter, and the risk of recurrence and/or death in TNBC is generally low 5 years after initial diagnosis. Also, in this study the period of tumor recurrence of TNBC after initial treatment was found to be extremely bipolarized.…”