Locoregional recurrence in patients with anastomotic leakage after anterior resection for rectal carcinoma

Abstract

Anastomotic leakage after anterior resection for rectal carcinoma is a risk factor for locoregional recurrence and decreases cancer-related survival.

The types of anastomotic leakage that develop following anterior resection for rectal cancer demonstrate distinct characteristics and oncologic outcomes

“…Determining the role of anastomotic leakage in long-term oncological outcome has important clinical pertinence as knowledge of an association may impact consideration for further treatment. However, the effects of anastomotic leakage on local recurrence and long-term oncologic outcomes are controversial [4][5][6][7][8][9][10][11]. Contradictory findings could have been reported because of inconsistent leakage definitions or variability in administered treatments [12].…”

Bovine Pericardium Buttress Reinforces Colorectal Anastomoses in a Canine Model

“…4,25,26 However, later studies suggested that anastomotic leakage results in increased local recurrence 9-13 and a decrease in cancer-specific survival. [9][10][11] Given the severity of a staple line failure, the concept of buttressing to strengthen the staple line is attractive. Currently, buttressing options include sealant materials, such as fibrin glue, and the incorporation of synthetic or biologic materials into the staple line.…”

“…The general incidence of anastomotic leakage varies, although is still thought to average approximately 10 percent. [1][2][3][4][5][6] Anastomotic leakage is influenced by numerous factors and is associated with a significant increase in 30-day mortality, 7,8 increased rates of local recurrence of cancer, [9][10][11][12][13] and is the most common cause of anastomotic strictures. 14 Despite the excellent results achieved with the use of mechanical stapling devices, staple lines are not immune to failure.…”

Der Chirurg als Kostenfaktor Kostenanalyse am Beispiel der chirurgischen Behandlung des Rektumkarzinoms

“…Aus eigenen Untersuchungen wissen wir, dass Anastomoseninsuffizienzen, vermutlich durch eine lokale Implantation von Tumorzellen, das Auftreten von Lokalrezidiven begünsti-gen können [11]. Die ohnehin äußerst hohen Kosten einer Anastomoseninsuffizienz würden somit durch die Kosten des Lokalrezidivs weiter in die Höhe getrieben.…”