Locomotor Activity Rhythm in the Field Mouse Mus booduga Phase-shifts to Melatonin Injections in a Dose-dependent Manner

Abstract

Melatonin is known to shift the phase of the locomotor activity rhythm in the field mouse Mus booduga in accordance with a type-I phase response curve (PRC), with phase delays during the subjective day and phase advances during late subjective night and the early subjective day. At CT4 (circadian time 4; i.e. 16 hr. after activity onset) and CT22 of the circadian cycle, a single dose of melatonin (1 mg/kg) is known to evoke maximum delay and maximum advance phase-shifts, respectively. We investigated the dose-dependent responses of the circadian pacemaker of these mice to a single dose of melatonin at the times for maximum delay and maximum advance. The circadian pacemaker responsible for the locomotor activity rhythm in these mice responded to various doses of melatonin in a dose-dependent manner with the magnitude of phase shifts increasing with dose.

Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study

“…This is consistent with findings in humans (17) and rodents (51). For instance, Deacon and Arendt (17) demonstrated a graded phase-shifting response in six human subjects who took 0.05, 0.5, or 5 mg melatonin (or placebo) for 1 day at 1700.…”