Loco-regional recurrence after surgical treatment of oral squamous cell carcinoma: Proposals for follow-up imaging based on literature, national guidelines and institutional experience

Loeffelbein, Denys J.; Eiber, Matthias; Mayr, P.; Souvatzoglou, Michael; Mücke, Thomas; Bomhard, Achim von; Kesting, Marco; Wolff, K.-D.

doi:10.1016/j.jcms.2015.06.020

Cited by 23 publications

(13 citation statements)

References 40 publications

(58 reference statements)

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“…OSCC is often treated with combination therapy using surgical resection and adjuvant radiation with or without chemotherapy [37]. The therapeutic agents are associated with severe adverse effects which cause a decrease in quality of life [38].…”

Section: Discussionmentioning

confidence: 99%

Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma

et al. 2016

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BackgroundMetformin is a biguanide, belonging to the oral hypoglycemic agents and is a widely used in the treatment of type 2 diabetes. Evidence indicate that Metformin inhibits cell proliferation in several human cancers and inhibits the Warburg phenomenon in tumor cells.ResultsLow PDH levels were observed in OSCC, and Metformin promotes an increase in PDH levels in hypoxic conditions. Metformin also reduced HIF-1α mRNA and protein levels. Metformin demonstrated antiproliferative effects, inhibited migration, increased the number of apoptotic cells and increased the transcription of caspase 3.ObjectiveThe present study aims to explore the effects of Metformin in hypoxic conditions. Specifically, we focused on pyruvate dehydrogenase (PDH), (hypoxia-inducible factor 1α) HIF-1α levels and the oral squamous cell carcinoma (OSCC) cell phenotype. Additionally, we also investigated a theoretical consequence of Metformin treatment.MethodsPDH levels in patients with OSCC and oral dysplasia were evaluated. Metformin was administered in vitro to test the effect of Metformin under hypoxic conditions. The results were complemented by Bioinformatics analyses.ConclusionsIn conclusion, our current findings show that Metformin reduces HIF-1α gene expression and increases PDH expression. Metformin inhibits cell proliferation and migration in the OSCC cell line model. Additionally, Metformin enhances the number of apoptotic cells and caspase 3 levels. Interestingly enough, Metformin did not increase the mutant p53 levels under hypoxic conditions.

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Section: Discussionmentioning

confidence: 99%

Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma

et al. 2016

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“…Only one of 10 tumors is diagnosed by a screening procedure (Mashberg and Samit, 1995). Recently, Loeffelbein et al reported on loco-regional recurrence rates of up to 26% (Loeffelbein et al, 2015). For tongue carcinoma in particular, a recurrence rate of approximately 42% within 5 years of follow-up was reported by Bachar et al (2011).…”

Section: Discussionmentioning

confidence: 99%

Oral brush biopsy and melanoma-associated antigens A (MAGE-A) staining in clinically suspicious lesions

Hartmann

Kipke

Rauthe

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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“…Hier nehmen v. a. die klinische Untersuchung mit Endoskopie und der Ultraschall eine besondere Rolle ein, aber auch eine regelmäßige Schnittbildgebung des Kopf-/Hals-Bereichs mittels Computertomografie (CT) oder Magnetresonanztomografie (MRT) wird zur Rezidivdetektion eingesetzt. Auch bei asymptomatischen Patienten werden in den ersten 3 Jahren nach Abschluss der Therapie mindestens halbjährliche und im vierten und fünften Jahr nach Abschluss der Therapie jährliche CToder MRT-Untersuchungen zur Rezidivdetektion empfohlen [20]. Obwohl mit der MRT ein Verfahren ohne Strahlenexposition zur Verfügung steht, wird die CT aufgrund der besseren Verfügbarkeit und der deutlich schnelleren Datenakquisition weiterhin in einem deutlich größeren Umfang als die MRT eingesetzt [22].…”

Section: Rezidivdiagnostikunclassified

PET/CT versus PET/MRT bei Kopf-Hals-Tumoren

Schaarschmidt¹,

Umutlu²,

Zarrad³

et al. 2021

TumorDiagnostik & Therapie

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Loco-regional recurrence after surgical treatment of oral squamous cell carcinoma: Proposals for follow-up imaging based on literature, national guidelines and institutional experience

Cited by 23 publications

References 40 publications

Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma

Metformin increases PDH and suppresses HIF-1α under hypoxic conditions and induces cell death in oral squamous cell carcinoma

Oral brush biopsy and melanoma-associated antigens A (MAGE-A) staining in clinically suspicious lesions

PET/CT versus PET/MRT bei Kopf-Hals-Tumoren

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