“LOCK”ing up allergic responses with a Polish probiotic

Liu, Yuying; Rhoads, J. Marc

doi:10.1038/cmi.2015.15

Cited by 1 publication

(1 citation statement)

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“…Dysbiosis of the intestinal microbiota is linkage to the pathogenesis and progression of chronic lung diseases, such as asthma. Disruption of the intestinal microbiota in early life could increase the risk of the development of asthma, and restoring the changed intestinal microbiota via probiotic treatment could attenuate the risk (Arrieta et al, 2015;Kozakova et al, 2016;Liu and Marc Rhoads, 2016). In addition, the intestinal microbiota is also broadly protective against respiratory infection (Tamburini and Clemente, 2017).…”

Section: Intestinal Microbiota Influences Lung Immunitymentioning

confidence: 99%

Role of microbiota on lung homeostasis and diseases

Wang

Tian

2017

Sci. China Life Sci.

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The lungs, as a place of gas exchange, are continuously exposed to environmental stimuli, such as allergens, microbes, and pollutants. The development of the culture-independent technique for microbiological analysis, such as 16S rRNA sequencing, has uncovered that the lungs are not sterile and, in fact, colonized by diverse communities of microbiota. The function of intestinal microbiota in modulating mucosal homeostasis and defense has been widely studied; however, the potential function of lung microbiota in regulating immunity and homeostasis has just begun. Increasing evidence indicates the relevance of microbiota to lung homeostasis and disease. In this review, we describe the distribution and composition of microbiota in the respiratory system and discuss the potential function of lung microbiota in both health and acute/chronic lung disease. In addition, we also discuss the recent understanding of the gut-lung axis, because several studies have revealed that the immunological interaction among the gut, the lung, and the microbiota was involved in this issue.

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Section: Intestinal Microbiota Influences Lung Immunitymentioning

confidence: 99%