COVID-19 has had unprecedented effects on people around the world, causing even the best performing communities to live in uncertainty for the future. How are people coping? We – the general public, the academic community, and policy makers – need answers. To that end we analyse novel data for Luxembourg, finding one third of residents report their mental health declined during lockdown and young adults (ages 18–44) fared the worst. The most important contributors observed are physical health, income, and employment characteristics, such as working from home, which people seemed to enjoy. To limit collateral damage on mental health, various tools are available, which we briefly discuss.