Location specific small RNA annealing to the HCV 5’ UTR promotes Hepatitis C Virus replication by favoring IRES formation and stimulating virus translation
Abstract:29Hepatitis C virus (HCV) genome replication requires annealing of a liver specific small-30 RNA, miR-122 to 2 sites on 5' untranslated region (UTR). Annealing has been reported to a) 31 stabilize the genome, b) promote translation, and c) induce the canonical HCV 5' UTR Internal 32Ribosome Entry Site (IRES) structure. In this report we identify the relative impact of small RNA 33 annealing on the three functions ascribed to miR-122 and generate a mechanistic model for miR-34 122 promotion of HCV. First, we id… Show more
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