Location of stimuli-responsive peptide sequences within silk-elastinlike protein-based polymers affects nanostructure assembly and drug–polymer interactions

Isaacson, Kyle J.; Jensen, Mark Martin; Steinhauff, Douglas; Kirklow, James E.; Mohammadpour, Raziye; Grunberger, Jason William; Cappello, Joseph; Ghandehari, Hamidreza

doi:10.1080/1061186x.2020.1757099

Cited by 8 publications

(2 citation statements)

References 56 publications

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“…A low concentration of SELP may be taken up into systemic circulation. SELPs have been used prior for liquid embolic applications, and illustrate minimal activation of the complement system, hepatoxicity, and hemolysis [24,47]. Obtaining complete blood profiles in future works could provide another indicator of safety and radiotoxicities.…”

Section: Discussionmentioning

confidence: 99%

An Oligomeric Sulfated Hyaluronan and Silk-Elastinlike Polymer Combination Protects against Murine Radiation Induced Proctitis

et al. 2022

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Semisynthetic glycosaminoglycan ethers (SAGEs) are short, sulfated hyaluronans which combine the natural properties of hyaluronan with chemical sulfation. In a murine model, SAGEs provide protection against radiation induced proctitis (RIP), a side effect of lower abdominal radiotherapy for cancer. The anti-inflammatory effects of SAGE have been studied in inflammatory diseases at mucosal barrier sites; however, few mechanisms have been uncovered necessitating high throughput methods. SAGEs were combined with silk-elastinlike polymers (SELPs) to enhance rectal accumulation in mice. After high radiation exposure to the lower abdominal area, mice were followed for 3 days or until they met humane endpoints, before evaluation of behavioral pain responses and histological assessment of rectal inflammation. RNA sequencing was conducted on tissues from the 3-day cohort to determine molecular mechanisms of SAGE–SELP. After 3 days, mice receiving the SAGE–SELP combination yielded significantly lowered pain responses and amelioration of radiation-induced rectal inflammation. Mice receiving the drug–polymer combination survived 60% longer than other irradiated mice, with a fraction exhibiting long term survival. Sequencing reveals varied regulation of toll like receptors, antioxidant activities, T-cell signaling, and pathways associated with pain. This investigation elucidates several molecular mechanisms of SAGEs and exhibits promising measures for prevention of RIP.

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Section: Discussionmentioning

confidence: 99%

An Oligomeric Sulfated Hyaluronan and Silk-Elastinlike Polymer Combination Protects against Murine Radiation Induced Proctitis

et al. 2022

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“…Table 1 reports sample ELPs/SELP-based sequences for drug delivery applications. [65][66][67][68][69][70][71][72][73][74] Tailor-made polysaccharide depending on multiple structures has been offered as a novel concept in recent years, which will open new windows for biomaterial universe. [75,76] Xanthan gum is an essential food ingredient and is produced by Xanthomonas campestris (X. campestris).…”

Section: Genetically Engineered Organic-based Nanoparticlesmentioning

confidence: 99%

Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications

Hajebi

Yousefiasl

Rahimmanesh

et al. 2022

Adv Healthcare Materials

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Conventional drug delivery systems are challenged by concerns related to systemic toxicity, repetitive doses, drug concentrations fluctuation, and adverse effects. Various drug delivery systems are developed to overcome these limitations. Nanomaterials are employed in a variety of biomedical applications such as therapeutics delivery, cancer therapy, and tissue engineering. Physiochemical nanoparticle assembly techniques involve the application of solvents and potentially harmful chemicals, commonly at high temperatures. Genetically engineered organisms have the potential to be used as promising candidates for greener, efficient, and more adaptable platforms for the synthesis and assembly of nanomaterials. Genetically engineered carriers are precisely designed and constructed in shape and size, enabling precise control over drug attachment sites. The high accuracy of these novel advanced materials, biocompatibility, and stimuli‐responsiveness, elucidate their emerging application in controlled drug delivery. The current article represents the research progress in developing various genetically engineered carriers. Organic‐based nanoparticles including cellulose, collagen, silk‐like polymers, elastin‐like protein, silk‐elastin‐like protein, and inorganic‐based nanoparticles are discussed in detail. Afterward, viral‐based carriers are classified, and their potential for targeted therapeutics delivery is highlighted. Finally, the challenges and prospects of these delivery systems are concluded.

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Advanced Nanomaterials, Medical Materials, and Nanotechnology for the Improved Patient Care

Ramesh,

Periya Nayagi Shilpa,

Lavanya

et al. 2024

New Technologies for Energy Transition Based on Sustainable Development Goals

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Location of stimuli-responsive peptide sequences within silk-elastinlike protein-based polymers affects nanostructure assembly and drug–polymer interactions

Abstract: Table S1. Goodness-of-fit values (R 2 -values) for various drug release models to the obtained dataset for the first six hours of doxorubicin release in the experimental microdialysis setup.

Cited by 8 publications

References 56 publications

An Oligomeric Sulfated Hyaluronan and Silk-Elastinlike Polymer Combination Protects against Murine Radiation Induced Proctitis

An Oligomeric Sulfated Hyaluronan and Silk-Elastinlike Polymer Combination Protects against Murine Radiation Induced Proctitis

Genetically Engineered Viral Vectors and Organic‐Based Non‐Viral Nanocarriers for Drug Delivery Applications

Advanced Nanomaterials, Medical Materials, and Nanotechnology for the Improved Patient Care

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