Location of Sentinel Lymph Node in Cervical Carcinoma and Factors Associated With Unilateral Detection

Wuntakal, Rekha; Papadopoulos, A.; Montalto, Stephen Attard; Perovic, Milica; Coutts, Michael; Devaja, Omer

doi:10.1097/igc.0000000000000539

Cited by 27 publications

(17 citation statements)

References 38 publications

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“…As such, while National Comprehensive Cancer Network (NCCN) cervical cancer guidelines include SLN mapping as an alternative in the surgical management of early-stage tumors, it cautions against its use in tumors ≥2 cm [7,8,10,12]. These recommendations were based on the cumulative body of evidence demonstrating worse detection rates as well as higher false negative rates in those with larger tumors [8,13]. Therefore, support for the use of SLN mapping as a substitute for complete lymphadenectomy in cervical cancer has remained limited, and only advisable in select patients with small primary tumors [7,8,10,11].…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node detection rates using indocyanine green in women with early-stage cervical cancer

Beavis

Salazar‐Marioni

Sinno

et al. 2016

Gynecologic Oncology

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Objective Our study objective was to determine feasibility and mapping rates using indocyanine green (ICG) for sentinel lymph node (SLN) mapping in early-stage cervical cancer. Methods We performed a retrospective review of all women who underwent SLN mapping with ICG during primary surgical management of early-stage cervical cancer by robotic-assisted radical hysterectomy (RA-RH) or fertility-sparing surgery. Patients were treated at two high-volume centers from 10/2012 to 02/2016. Completion pelvic lymphadenectomy was performed after SLN biopsy; additionally, removal of clinically enlarged/suspicious nodes was part of the SLN treatment algorithm. Results Thirty women with a median age of 42.5 and BMI of 26.5 were included. Most (90%) had stage IB disease, and 67% had squamous histology. RA-RH was performed in 86.7% of cases. One patient underwent fertility-sparing surgery. Median cervical tumor size was 2.0 cm. At least one SLN was detected in all cases (100%), with bilateral mapping achieved in 87%. SLN detection was not impacted by tumor size and was most commonly identified in the hypogastric (40.3%), obturator (26.0%), and external iliac (20.8%) regions. Five cases of lymphatic metastasis were identified (16.7%): three in clinically enlarged SLNs, one in a clinically enlarged non-SLN, and one case with cytokeratin positive cells in an SLN. All metastatic disease would have been detected even if full lymphadenectomy had been omitted from our treatment algorithm, Conclusions SLN mapping with ICG is feasible and results in high detection rates in women with early-stage cervical cancer. Prospective studies are needed to determine if SLN mapping can replace lymphadenectomy in this setting.

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Section: Introductionmentioning

confidence: 99%

Sentinel lymph node detection rates using indocyanine green in women with early-stage cervical cancer

Beavis

Salazar‐Marioni

Sinno

et al. 2016

Gynecologic Oncology

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“…В связи с этим вопросы органосо-храняющего лечения рака шейки матки в течение многих десятилетий продолжают оставаться в центре внимания ведущих отечественных и зарубежных онкологов. Предпо-сылками к разработке методов лечения начального инва-зивного рака шейки матки с сохранением репродуктивной функции явились особенности канцерогенеза, а именно редкость поражения яичников и редкость распростра-нения на тело матки [2]. Согласно рекомендациям NCCN Guidelines Version 1.2017 Cervical Cancer при стадиях IА1-IВ рекомендовано применение органосохраняющего лечения в объеме радикальной трахелэктомии с тазовой лимфодиссекцией с определением сторожевых лимфа-тических узлов.…”

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“…Согласно рекомендациям NCCN Guidelines Version 1.2017 Cervical Cancer при стадиях IА1-IВ рекомендовано применение органосохраняющего лечения в объеме радикальной трахелэктомии с тазовой лимфодиссекцией с определением сторожевых лимфа-тических узлов. Поскольку абсолютное число больных, являющихся потенциальными кандидатами для органосо-храняющего лечения, достаточно велико, это обуславли-вает разработку новых подходов к лечению РШМ с сохра-нением фертильности [2,3]. Потенциально радикальная абдоминальная трахелэктомия разрабатывалась как адек-ватная альтернатива расширенным операциям у пациен-ток с микроинвазивным и инвазивным РШМ при размерах опухоли до 2 см.…”

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Оптимизация Современных Подходов В Лечении Гинекологического Рака Основных Локализаций

et al. 2017

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“…The use of such radiopharmaceuticals as Nanocoll, 99m Tc-nanocolloid, Nanocis, Microlite and Sulfurcolloid for SLN detection have several drawbacks [8,9]. Their applications are limited by their complex manufacturing process and high cost.…”

Section: Introductionmentioning

confidence: 99%

The first experience of using 99mTc-Al2O3-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients

Синилкин¹,

Chernov²,

Lyapunov

et al. 2016

AIP Conference Proceedings

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Abstract. The purpose of the study was to evaluate the feasibility of using 99m Tc-Al 2 O 3 -based radiopharmaceutical, a novel molecular imaging agent for sentinel lymph node detection in patients with invasive cervical cancer. The study included 23 cervical cancer patients (T1aN M -T2bN M ) treated at the Tomsk Cancer Research Institute. In the 18 hours before surgery, 80 MBq of the 99m Tc-Al 2 O 3 in peritumoral injected, followed by single-photon emission computed tomography (SPECT) of the pelvis and intraoperative SLN identification. Twenty-seven SLNs were detected by SPECT, and 34 SLNs were identified by intraoperative gamma probe. The total number of identified SLNs per patient ranged from 1 to 3 (the mean number of SLNs was 1.4 per patient). The most common site for SLN detection was the external iliac region (57.2%), followed by the internal iliac (14%), obturator (14%), presacral and retrosacral regions (14%), and the parametrial region (1%). Sensitivity in detecting SLNs was 100% for intraoperative SLN identification and 79% for SPECT image.

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Location of Sentinel Lymph Node in Cervical Carcinoma and Factors Associated With Unilateral Detection

Cited by 27 publications

References 38 publications

Sentinel lymph node detection rates using indocyanine green in women with early-stage cervical cancer

Sentinel lymph node detection rates using indocyanine green in women with early-stage cervical cancer

Оптимизация Современных Подходов В Лечении Гинекологического Рака Основных Локализаций

The first experience of using 99mTc-Al2O3-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients

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