Location of neutralizing epitopes on the hemagglutinin-esterase protein of influenza C virus

Matsuzaki, Masami; Sugawara, Kanetsu; Adachi, Kazunari; Hongō, Seiji; Nishimura, Hidekazu; Kitame, Fumio; Nakamura, Kenzo

doi:10.1016/0042-6822(92)90683-g

Cited by 28 publications

(23 citation statements)

References 39 publications

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“…These observations suggest that the production of antigenic variants by immune selection has not occurred for the last 3 decades. This finding is well comparable with our previous indication that HE protein might no longer be able to evolve in response to antibody pressure because of a high degree of functional constraint on the change of its immunodominant region, which is near the receptor-binding site (15,21). On the other hand, as shown in Fig.…”

Section: Discussionsupporting

confidence: 81%

Frequent Reassortment among Influenza C Viruses

Matsuzaki

Mizuta²,

Sugawara

et al. 2003

J Virol

126

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In a 9-year survey from December 1990 to December 1999 in Sendai City, Japan, we succeeded in isolating a total of 45 strains of influenza C virus. These 45 strains were isolated in clusters within 4 months in a year, especially from winter to early summer. Previous studies of the hemagglutinin-esterase genes of various influenza C virus isolates revealed the existence of five distinct virus lineages (Aichi/1/81-, Yamagata/26/81-, Mississippi/80-, Sao Paulo/82-, and Kanagawa/1/76-related lineage) in Japan between 1970 and the early 1990s

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Section: Discussionsupporting

confidence: 81%

Frequent Reassortment among Influenza C Viruses

Matsuzaki

Mizuta²,

Sugawara

et al. 2003

J Virol

126

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“…Although there are no sites under significant positive selection, some sites responsible for antigenicity [11] showed positive selection pressure (Supplementary Table S2 and positive blue bars in Figure 5). Additionally, other positions in antigenic sites showed negative selection pressure (Supplementary Table S2 and negative blue bars in Figure 5).…”

Section: Resultsmentioning

confidence: 99%

“…The fourth segment of the viral genome encodes hemagglutinin-esterase (HE) glycoprotein [9], which determines the major antigenicity of the virus and has a variety of functions in the viral replication cycle. At least nine antigenic sites (A-1 to A-5 and B-1 to B-4) of the HE glycoproteins are proposed; of them, amino acid positions responsible for four antigenic sites have been identified [10,11,12]. In addition, glycosylation of the proteins also affects the virus’ antigenicity [10].…”

Section: Introductionmentioning

confidence: 99%

Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses

Furuse

Matsuzaki

Nishimura

et al. 2016

Viruses

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Infections with the influenza C virus causing respiratory symptoms are common, particularly among children. Since isolation and detection of the virus are rarely performed, compared with influenza A and B viruses, the small number of available sequences of the virus makes it difficult to analyze its evolutionary dynamics. Recently, we reported the full genome sequence of 102 strains of the virus. Here, we exploited the data to elucidate the evolutionary characteristics and phylodynamics of the virus compared with influenza A and B viruses. Along with our data, we obtained public sequence data of the hemagglutinin-esterase gene of the virus; the dataset consists of 218 unique sequences of the virus collected from 14 countries between 1947 and 2014. Informatics analyses revealed that (1) multiple lineages have been circulating globally; (2) there have been weak and infrequent selective bottlenecks; (3) the evolutionary rate is low because of weak positive selection and a low capability to induce mutations; and (4) there is no significant positive selection although a few mutations affecting its antigenicity have been induced. The unique evolutionary dynamics of the influenza C virus must be shaped by multiple factors, including virological, immunological, and epidemiological characteristics.

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“…However, ICV HEF binds to N-acetyl-9-O-acetylneuraminic acid rather than to N-acetyl-neuraminic acid for influenza A and B viruses [36]. HEF is the major target for host neutralizing antibodies, which appear to bind to epitopes near the receptor-binding site and the esterase site [37][38][39][40][41][42]. Human CD8+ T cells recognize epitopes of ICV internal proteins, some of which are conserved in IAV and IBV [43].…”

Section: Virus Structurementioning

confidence: 99%

Epidemiology and Clinical Characteristics of Influenza C Virus

Sederdahl

Williams

2020

Viruses

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Influenza C virus (ICV) is a common yet under-recognized cause of acute respiratory illness. ICV seropositivity has been found to be as high as 90% by 7-10 years of age, suggesting that most people are exposed to ICV at least once during childhood. Due to difficulty detecting ICV by cell culture, epidemiologic studies of ICV likely have underestimated the burden of ICV infection and disease. Recent development of highly sensitive RT-PCR has facilitated epidemiologic studies that provide further insights into the prevalence, seasonality, and course of ICV infection. In this review, we summarize the epidemiology and clinical characteristics of ICV.

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Location of neutralizing epitopes on the hemagglutinin-esterase protein of influenza C virus

Cited by 28 publications

References 39 publications

Frequent Reassortment among Influenza C Viruses

Frequent Reassortment among Influenza C Viruses

Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses

Epidemiology and Clinical Characteristics of Influenza C Virus

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