Location of Keloids and Its Treatment Modality May Influence the Keloid Recurrence in Children

Park, Tae Hwan; Chang, Choong Hyun

doi:10.1097/scs.0000000000001747

Cited by 24 publications

(19 citation statements)

References 19 publications

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“…Sites of predilection of keloids include the earlobes and jaw region of the head and neck, the anterior chest and shoulder, and the extremities. Rarer sites include the perineum, palms, and soles . The majority of our subjects developed keloids in the head and neck region, and within this region, the earlobe was most frequently involved, a finding the Park and colleagues previously reported.…”

Section: Discussionsupporting

confidence: 62%

“…3,14,15 The only significant variable associated with recurrence in our study was the size of the keloid. In some studies, keloids on the trunk and extremities and those undergoing multimodal treatment have been associated with recurrence, 6 whereas others have found no relationship between treatment outcome and keloid location, duration of the keloid, or etiology. 12 The limitations of this study include its retrospective nature resulting in incomplete data retrieval, the short duration of followup, and loss to follow-up.…”

Section: Treatment and Treatment Outcomesmentioning

confidence: 99%

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Pediatric keloids: A 6‐year retrospective review

Michael

Ademola

Olawoye

et al. 2017

Pediatric Dermatology

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Background/Objectives Keloids are reportedly rare at the extremes of life. We sought to describe the epidemiology of pediatric keloids seen at the plastic surgery outpatient department of the University College Hospital, Ibadan. Methods We retrospectively reviewed all children younger than 19 years who presented with nonburn keloids between 2008 and 2014. Data were obtained on age; duration, size, and location of the keloid; family history; mode of treatment; and outcome. Outcome variables were recurrence and wound complications. Data were analyzed using the Pearson chi‐square test for discreet variables and the independent‐sample t test for continuous variables. P < .05 was taken as statistically significant. Results Within the review period, 304 patients presented with keloids, of whom 40 (13.1%) were younger than 19 years. There was a female preponderance (n = 23, 57.5%). The mean age at onset of the keloid was 9.3 years (range 3 months‐18 years). Thirty (75%) patients had keloids in the head and neck region. Keloids were sporadic in 31 (77.5%) patients. Nineteen (47.5%) patients had multimodal treatment for keloid. The recurrence rate was 20%. Recurrence was significantly associated with the size of the lesion (P = .003). Conclusion Keloids during childhood are not rare. More attention should be paid to the management of keloids in this age group.

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Section: Discussionsupporting

confidence: 62%

Section: Treatment and Treatment Outcomesmentioning

confidence: 99%

Pediatric keloids: A 6‐year retrospective review

Michael

Ademola

Olawoye

et al. 2017

Pediatric Dermatology

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“…Keloid scarring is a dermal fibroproliferative disease characterized by excessive deposition of collagen secondary to skin damage such as trauma, burns or surgery . The majority of keloid scars occur in the sternum handle, shoulder deltoid, jaw and ear, although the reasons why keloid disease is more common at specific body sites remains unclear. Keloid scars are hard, often accompanied by itching and pain and a defining characteristic is the proliferation of the keloid scar beyond the initial boundary of the injury .…”

Section: Introductionmentioning

confidence: 99%

From genetics to epigenetics: new insights into keloid scarring

Deng

Alghamdi

et al. 2017

Cell Proliferation

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Keloid scarring is a dermal fibroproliferative response characterized by excessive and progressive deposition of collagen; aetiology and molecular pathology underlying keloid formation and progression remain unclear. Genetic predisposition is important in the pathogenic processes of keloid formation, however, environmental factors and epigenetic mechanisms may also play pivotal roles. Epigenetic modification is a recent area of investigation in understanding the molecular pathogenesis of keloid scarring and there is increasing evidence that epigenetic changes may play a role in induction and persistent activation of fibroblasts in keloid scars. Here we have reviewed three epigenetic mechanisms: DNA methylation, histone modification and the role of non-coding RNAs. We also review the evidence that these mechanisms may play a role in keloid formation - in future, it may be possible that epigenetic markers may be used instead of prognostic or diagnostic markers here. However, there is a significant amount of work required to increase our current understanding of the role of epigenetic modification in keloid disease.

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“…There was no reported case of auricular keloid steroid treatment causing adrenal suppression leading to cushingoid manifestation. This may be due to the preponderance to larger keloid formation more at the trunk and extremities in children due to scalding, bumps, and falls [18]. Moreover, auricular keloid is relatively smaller and may be managed expectantly due to high rates of recurrence or reserved for surgery at a much older age.…”

Section: Discussionmentioning

confidence: 99%

Gangrenous Keloid of the Ear Pinna Following Intralesional Triamcinolone Injection: Proper Consent Is Essential

Roy

Adaikappan

Letchumanan

et al. 2019

SN Compr. Clin. Med.

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Keloid formation involving ears is commonly encountered in medical practice. There are variable treatment options with different outcomes particularly on recurrence. With treatment, there might be complications with varying severity. One of the commonest preferred treatment is intralesional steroid injection using triamcinolone acetonide (TCA). We encountered a complication of intralesional TCA injection when a patient who had an ear keloid developed gangrenous keloid involving the pinna after receiving a TCA injection that required surgical debridement. We believe such a complication has been underreported. We reviewed the literatures to highlight the complications following TCA injection of ear keloid.

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Location of Keloids and Its Treatment Modality May Influence the Keloid Recurrence in Children

Abstract: The authors successfully treated pediatric keloids selecting proper regimen according to anatomic locations. Based on our study of 230 pediatric keloids, 2 characteristics were linked to the risk of keloid recurrence.

Cited by 24 publications

References 19 publications

Pediatric keloids: A 6‐year retrospective review

Pediatric keloids: A 6‐year retrospective review

From genetics to epigenetics: new insights into keloid scarring

Gangrenous Keloid of the Ear Pinna Following Intralesional Triamcinolone Injection: Proper Consent Is Essential

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