Location and Function of B‐Cell Lineages<sup>a</sup>

Kroese, Frans G. M.; Ammerlaan, W.; Deenen, Gerrit Jan

doi:10.1111/j.1749-6632.1992.tb24592.x

Cited by 58 publications

(27 citation statements)

References 49 publications

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“…transgenics that the B cells of the intestinal lamina propria which produce IgA are predominantly of the B-1 type [41]. However, in the present data we note the ALD also had an increase in circulating IgG, from which it may be inferred that either the relatively increased B-1b subset or the few remaining B-2 cells produced excess IgG in these patients.…”

Section: Cd45racontrasting

confidence: 53%

Loss of the CD5+ and CD45RAhi B cell subsets in alcoholics

Cook¹,

Waldschmidt²,

Cook³

et al. 1996

Clinical and Experimental Immunology

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SUMMARYChronic alcoholics are frequently immunodeficient, have polyclonal hypergammaglobulinaemia, and often have autoantibodies. Recent work in other diseases has shown that functional distinctions of possible relevance to autoimmunity and immunodeficiency can be found among the B cell subsets defined by differential expression of the surface markers CD5 and CD45RA. Therefore, we have evaluated the CD5,CD45RA B cell subsets of both chronic alcoholics without evidence of active liver disease (AWLD), and alcoholics admitted for acute alcoholic liver disease (ALD). Mean B cell numbers were normal in AWLD, but significantly reduced in ALD. CD45RAlo . This subset appears phenotypically similar to the IgM-producing CD5 ÿ CD45RA lo subset described by others, and may be enriched for autoantibody-producing cells. One outlier patient was an ALD with 61% of B cells which were CD5, which also is a profile consistent with increased autoantibody production.

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Section: Cd45racontrasting

confidence: 53%

Loss of the CD5+ and CD45RAhi B cell subsets in alcoholics

Cook¹,

Waldschmidt²,

Cook³

et al. 1996

Clinical and Experimental Immunology

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“…Murine CD5 þ B cells constitute about 60% of peritoneal B cells, but only less than 2% of B cells in spleens and lymph nodes [2,3,14]. We have shown that murine B-1 cells play pivotal roles in the induction of autoimmune haemolytic anaemia in anti-erythrocyte immunoglobulin transgenic mice [15,16].…”

Section: Introductionmentioning

confidence: 84%

Preferential Localization of Human CD5⁺ B Cells in the Peritoneal Cavity

Nisitani¹,

Murakami²,

Akamizu³

et al. 1997

Scand J Immunol

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In a transgenic mouse model of autoimmune haemolytic anaemia, CD5 þ B lymphocytes localized in the peritoneal cavity are shown to play an important role in the onset of autoimmune disease. The authors have examined whether CD5 þ B cells are present in the peritoneal cavity of 12 human individuals with noninvasive gastrointestinal tumours and found that in humans CD5 þ B cells preferentially lodge in the peritoneal cavity as compared to the peripheral blood and spleen while the numbers of the peritoneal B lymphocytes in humans are much lower than in mice and vary widely between individuals.

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“…Primary antibodies used for the immunohistological staining of lymphocytes were polyclonal or monoclonal species cross-reactive antibodies raised against intracytoplasmic peptide sequences of human T or B lymphocyte associated molecules (Mason et al 1989(Mason et al , 1992Mason, 1991 ;Kroese et al 1992). A monoclonal antiplatypus serum immunoglobulin (Ig) was produced according to the method of Fazekas de St Groth & Scheidegger (1980) and used to stain plasma cells.…”

Section: Primary Antibodies and Staining Methods For Immunohistologymentioning

confidence: 99%

Histological and immunohistological investigation of lymphoid tissue in the platypus (Ornithorhynchus anatinus)

et al. 1999

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The gross and histological appearance and the distribution of T and B lymphocytes and plasma cells are described for lymphoid tissues obtained from 15 platypuses. The spleen was bilobed and surrounded by a thick capsule of collagen, elastic fibres and little smooth muscle. White pulp was prominent and included germinal centres and periarterial lymphoid sheaths. Red pulp contained haematopoietic tissue. A thin lobulated thymus was located within the mediastinum overlying the heart. The cortex of lobules consisted of dense aggregates of small and medium lymphocytes, scattered macrophages and few reticular epithelial cells. In the medulla, Hassall's corpuscles were numerous, lymphocytes were small and less abundant, and reticular cells were more abundant than in the cortex. Lymphoid nodules scattered throughout loose connective tissue in cervical, pharyngeal, thoracic, mesenteric and pelvic sites measured 790p370 µm (meanp.., n l 39) in diameter, the larger of which could be observed macroscopically. These consisted of single primary or secondary follicles supported by a framework of reticular fibres. Macrophages were common in the germinal centres. The platypus had a full range of gut-associated lymphoid tissue. No tonsils were observed macroscopically but histologically they consisted of submucosal follicles and intraepithelial lymphocytes. Peyer's patches were not observed macroscopically but histologically they consisted of several prominent submucosal secondary follicles in the antimesenteric wall of the intestine. Caecal lymphoid tissue consisted of numerous secondary follicles in the submucosa and densely packed lymphocytes in the lamina propria. Bronchus-associated lymphoid tissue was not observed macroscopically but was identified in 7 of 11 platypus lungs assessed histologically. Lymphoid cells were present as primary follicles associated with bronchi, as aggregates adjacent to blood vessels and as intraepithelial lymphocytes. The distribution of T lymphocytes, identified with antihuman CD3 and CD5, and B lymphocytes and plasma cells, identified with antihuman CD79a and CD79b and antiplatypus immunoglobulin, within lymphoid tissues in the platypus was similar to that described in therian mammals except for an apparent relative paucity of B lymphocytes. This study establishes that the platypus has a well-developed lymphoid system which is comparable in histological structure to that in therian mammals. It also confirms the distinctiveness of its peripheral lymphoid tissue, namely lymphoid nodules. Platypus lymphoid tissue has all the essential cell types, namely T and B lymphocytes and plasma cells, to mount an effective immune response against foreign antigens.

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Location and Function of B‐Cell Lineages^a

Cited by 58 publications

References 49 publications

Loss of the CD5+ and CD45RAhi B cell subsets in alcoholics

Loss of the CD5+ and CD45RAhi B cell subsets in alcoholics

Preferential Localization of Human CD5⁺ B Cells in the Peritoneal Cavity

Histological and immunohistological investigation of lymphoid tissue in the platypus (Ornithorhynchus anatinus)

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Location and Function of B‐Cell Lineagesa

Cited by 58 publications

References 49 publications

Loss of the CD5+ and CD45RAhi B cell subsets in alcoholics

Loss of the CD5+ and CD45RAhi B cell subsets in alcoholics

Preferential Localization of Human CD5+ B Cells in the Peritoneal Cavity

Histological and immunohistological investigation of lymphoid tissue in the platypus (Ornithorhynchus anatinus)

Contact Info

Product

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About

Location and Function of B‐Cell Lineages^a

Preferential Localization of Human CD5⁺ B Cells in the Peritoneal Cavity