Location and Characteristics of Warfarin Associated Intracranial Hemorrhage

Lee, Sang-Min; Park, Hyun-Seok; Choi, Jeong Hee; Huh, Jae-Taeck

doi:10.7461/jcen.2014.16.3.184

Cited by 7 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The potential explanation lies in the following: cerebral amyloid angiopathy represents the pathohistological basis of the lobar pICH, while vasculopathy of deep perforated arteries is a characteristic of the deep cerebral localization [23,24]. It is assumed that there are different sensitivities of these two in the AT and OACT group [25]. It is also unavoidable that HTA primarily increases the risk of the non-lobar pICH, while warfarin is a RF predominantly for lobar pICH [14].…”

Section: Discussionmentioning

confidence: 99%

Effect of anticoagulant and antiplatelet therapy on the occurrence of primary intracerebral hemorrhage

et al. 2018

View full text Add to dashboard Cite

Introduction. The incidence of intracerebral hemorrhage related to oral anticoagulant and antiplatelet therapy has an increasing trend, thus it may be a potential indicator of unvaforable outcome of primary intracerebral hemorrhage. The aim of the study was to determine the effect of these therapies on the occurrence, localization and outcome of primary intracerebral hemorrhage. Material and Methods. A retrospective study included 246 patients with first time diagnosed primary intracerebral hemorrhage. Patients were divided into three groups, according to the drugs they have used. The incidence, anatomical distribution of primary intracerebral hemorrhage and survival/mortality rates were observed in all groups. Results. Antiplatelet therapy was used by 20.3% of patients, 8.2% received antocoagulant therapy, while the rest of 71.5% didn not take these drugs in the premorbid period. The most common risk factor was arterial hypertension (97.2%). In all groups, patients had a tendency for supratentorial hematomas. Only alcohol consumption had a significant impact on the localization of hemorrhage (p < 0,05). There was no statistically significant difference between groups in National Institutes of Health Stroke Scale score on admission and a modified Rankin Scale Score at discharge. Oral anticoagulant users presented with the highest mortality rate in the first 24 hours (odds ratio-2.5). Patients in other two groups showed a significantly higher survival rate (odds ratio-1.5). Conclusion. Oral anticoagulant users had significantly higher National Institutes of Health Stroke Scale score on admission with an increased risk for early death. A significantly higher percentage of survival was noted in other two groups. Approximately 2/3 of all patients had poor functional recovery.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of anticoagulant and antiplatelet therapy on the occurrence of primary intracerebral hemorrhage

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Un pequeño porcentaje de estos sangrados son atribuidos a malformaciones 9 vasculares, más frecuentes en el joven . Así también, la HIC asociada al uso de warfarina tiende a ocurrir con más 64 frecuencia a nivel lobar .…”

Section: Introductionunclassified

Efectos de la edad sobre la morbimortalidad de la hemorragia intracerebral

Kita¹

2015

Rev. virtual Soc. Parag. Med. Int

View full text Add to dashboard Cite

ResumenIntroducción: los datos disponibles sobre factores de riesgo y mortalidad en sujetos jóvenes tras una hemorragia intracerebral (HIC) son muy escasos. Objetivo: determinar los factores de riesgo en dicha población y comparar la frecuencia de mortalidad y complicaciones asociadas entre adultos menores de 50 años edad y aquellos de 50 años o más. Material y métodos: se elaboraron dos cohortes, una de pacientes adultos menores de 50 años con HIC (cohorte 1) y otra de adultos de 50 años o más con HIC (cohorte 2), admitidos en el Hospital Nacional de Itauguá en el período [2013][2014]. Resultados: fueron incluidos 53 pacientes en la cohorte 1 y 89 en la cohorte 2. Ambas cohortes fueron similares en sus aspectos demográficos y clínicos. La mortalidad fue superior en la cohorte 2. La escala de Glasgow al egreso fue mayor en la cohorte 1. No hubo diferencias significativas entre ambas poblaciones en cuanto a incidencia de complicaciones infecciosas y neurológicas derivadas del hematoma. Conclusión: la HIC en sujetos mayores de 50 años de edad se asocia a una mayor mortalidad.Palabras claves: hemorragia intracerebral espontánea; edad; mortalidad; complicaciones neurológicas. Abstract Introduction:The available data about risk factors and mortality in young individuals after an intracerebral hemorrhage (ICH) are limited. Objectives: To determine the risk factors in this population and then compare the mortality frequency and associated complications between adults younger than 50 years and those of 50 years old or more. Materials and methods: Two cohorts were created, one of adult patients younger than 50 years old with ICH (cohort 1) and another of adults of 50 years and more with ICH (cohort 2), admitted into the National Hospital of Itauguá in the 2013-2014 period. Results: Fifty three patients were included in cohort 1 and 89 in cohort 2. Both cohorts were similar in the demographic and clinical aspects. Mortality was higher in cohort 2. Glasgow scale at discharge was higher in cohort 1. There were not any significant differences between both populations in relation to the incidence of infectious and neurological complications originated in the hematoma. Conclusion:The ICH in subjects older than 50 years old is associated with higher mortality.Keywords: spontaneous intracerebral hemorrhage; age; mortality; neurological complications. IntroducciónEl accidente vascular cerebral (ACV) es una entidad patológica caracterizada por un déficit neurológico atribuido a una lesión focal aguda del sistema nervioso central de causa vascular, en la que se incluyen al infarto cerebral, la hemorragia intracerebral (HIC) y la hemorragia subaracnoidea, consideradas en el mundo entero 1 como las causas más importantes de discapacidad y muerte .La rápida instalación de signos clínicos indicativos de disfunción neurológica debido a una colección focal de sangre en el parénquima cerebral o en el sistema ventricular, no generado por un trauma, es lo que 1 define al ACV ocasionado por una hemorragia intracerebral espontánea .Después de...

show abstract

“…6)[37,38]. Das Maß der Antikoagulation bei VKAermittelt über die International Normalized Ratio (INR)ist direkt mit der Inzidenz des Auftretens einer ICB assoziiert und korreliert mit der Größe der Blutung[39]. Die Reversierung einer INR-Erhöhung stellt bei Patienten mit ICB oder Subduralhämatom (SDH) unter Therapie mit VKA einen der wichtigsten Handlungsschritte dar.…”

unclassified

Point-of-Care-Gerinnungsdiagnostik in der Neurochirurgie

Adam¹,

Füllenbach²,

Lindau³

et al. 2018

Anästhesiol Intensivmed Notfallmed Schmerzther

View full text Add to dashboard Cite

Disorders of the coagulation system can seriously impact the clinical course and outcome of neurosurgical patients. Due to the anatomical location of the central nervous system within the closed skull, bleeding complications can lead to devastating consequences such as an increase in intracranial pressure or enlargement of intracranial hematoma. Point-of-care (POC) devices for the testing of haemostatic parameters have been implemented in various fields of medicine. Major advantages of these devices are that results are available quickly and that analysis can be performed at the bedside, directly affecting patient management. POC devices allow identification of increased bleeding tendencies and therefore may enable an assessment of hemorrhagic risks in neurosurgical patients. Although data regarding the use of POC testing in neurosurgical patients are limited, they suggest that coagulation testing and hemostatic therapy using POC devices might have beneficial effects in this patient population. This article provides an overview of the application of point-of-care coagulation testing in clinical practice in neurosurgical patients.

show abstract

Location and Characteristics of Warfarin Associated Intracranial Hemorrhage

Cited by 7 publications

References 27 publications

Effect of anticoagulant and antiplatelet therapy on the occurrence of primary intracerebral hemorrhage

Effect of anticoagulant and antiplatelet therapy on the occurrence of primary intracerebral hemorrhage

Efectos de la edad sobre la morbimortalidad de la hemorragia intracerebral

Point-of-Care-Gerinnungsdiagnostik in der Neurochirurgie

Contact Info

Product

Resources

About