The development of region-based livestock commodities is the first step and plays an important role in formulating regional food security policies derived from animal protein, particularly from the aspect of the availability of food derived from animal protein. This paper aimed to determine the potential for the development of superior livestock commodities to support the availability of animal protein based on the level of ability or regional potential of each region/district in South Sulawesi. This information can be used as a reference in determining the appropriate regional development method for the development of livestock commodities in South Sulawesi. The research method emphasizes the analysis of secondary data obtained from BPS South Sulawesi in 2021. To find out the present status and potential for the development of livestock commodities for each district, Location Quotient (LQ) analysis is used, using indicators of population size and production of livestock commodities. The conclusion potential for the development of livestock commodities is obtained, ducks, laying hens, and goats are the best livestock commodities in South Sulawesi because they have an LQ value of > 1 spread across 14 districts (ducks) and 13 districts (laying hens, goats), beef cattle commodity found in 12 districts, then there are native chicken and horse commodity with their distributed found in 11 districts. The highest potential for the development of livestock commodities was Gowa, Maros, and Selayar Islands Regencies.