Locally transplanted human urine-induced nephron progenitor cells contribute to renal repair in mice kidney with diabetic nephropathy

Gao, Wei-Wei; Chun, So Young; Kim, Bum Soo; Ha, Yun‐Sok; Lee, Jun Nyung; Lee, Eun Hye; Kim, In Yong; You, Seungkwon; Kwon, Tae Gyun

doi:10.1016/j.bbrc.2022.09.015

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…This approach enhances kidney therapy by reducing glomerular hypertrophy, tubulointerstitial fibrosis, and markers like blood urea nitrogen, serum creatinine, and albuminuria. It also lowers inflammation/fibrosis ratios while bolstering renal regenerative capacity [ 52 ]. In a study, Kim et al investigated the mechanisms underlying USCs' ability to inhibit fibrosis in HK-2 cells, which is associated with CKD progression.…”

Section: Protection Of Kidney Injurymentioning

confidence: 99%

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

Sun,

Zhao,

Yang

et al. 2024

Heliyon

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Section: Protection Of Kidney Injurymentioning

confidence: 99%

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

Sun,

Zhao,

Yang

et al. 2024

Heliyon

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“…More importantly, ALA can also inhibit inflammation by targeting NF-KB and decreasing the release of inflammatory cytokines ( Figure 4 ). Therefore, it has been demonstrated that by scavenging oxygen free radicals, ALA could increase glomerular function and decrease renal inflammation [ 31 ]. Studies have also shown that treatment with ALA can decrease acute kidney injury by lowering serum blood urea nitrogen, creatinine levels, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β), thereby decreasing endothelin-1 vasoconstriction, neutrophil diffusion, and inflammation in the kidneys.…”

Section: Alpha-lipoic Acidmentioning

confidence: 99%

“…Nutrients 2023, 15, x FOR PEER REVIEW 3 of 18 crease renal inflammation [31]. Studies have also shown that treatment with ALA can decrease acute kidney injury by lowering serum blood urea nitrogen, creatinine levels, tumor necrosis factor-alpha (TNF-⍺), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β), thereby decreasing endothelin-1 vasoconstriction, neutrophil diffusion, and inflammation in the kidneys.…”

Section: Alpha-lipoic Acidmentioning

confidence: 99%

Renal-Protective Roles of Lipoic Acid in Kidney Disease

Kamt

Liu

2023

Nutrients

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The kidney is a crucial organ that eliminates metabolic waste and reabsorbs nutritious elements. It also participates in the regulation of blood pressure, maintenance of electrolyte balance and blood pH homeostasis, as well as erythropoiesis and vitamin D maturation. Due to such a heavy workload, the kidney is an energy-demanding organ and is constantly exposed to endogenous and exogenous insults, leading to the development of either acute kidney injury (AKI) or chronic kidney disease (CKD). Nevertheless, there are no therapeutic managements to treat AKI or CKD effectively. Therefore, novel therapeutic approaches for fighting kidney injury are urgently needed. This review article discusses the role of α-lipoic acid (ALA) in preventing and treating kidney diseases. We focus on various animal models of kidney injury by which the underlying renoprotective mechanisms of ALA have been unraveled. The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron. We highlight the common mechanisms of ALA’s renal protective actions that include decreasing oxidative damage, increasing antioxidant capacities, counteracting inflammation, mitigating renal fibrosis, and attenuating nephron cell death. It is by these mechanisms that ALA achieves its biological function of alleviating kidney injury and improving kidney function. Nevertheless, we also point out that more comprehensive, preclinical, and clinical studies will be needed to make ALA a better therapeutic agent for targeting kidney disorders.

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“…We have presented strong evidence that voided USCs originate from the parietal cells of kidney glomeruli [3] . These cells retain chromosomal stability over cultured passages in vitro and are safe to use in vivo without any risk of oncogenicity [58][59][60][61][62][63][64][65][66][67][68] . Furthermore, these cells can be easily isolated and expanded [2,3,19] , which offers clear advantages over stem cells from other sources such as bone marrow or adipose tissue [40,69] .…”

Section: Stemness Properties Of Uscsmentioning

confidence: 99%

“…USCs have shown promise in the treatment of various kidney diseases, including chronic kidney disease due to diabetics [ 67,89 ] , ischemia combined with drug toxicity [ 68 ] , and acute kidney injury. In animal studies, USCs have been shown to differentiate into kidney cells, inhabit inflammatory, fibrosis, apoptosis, and oxidative stress, and promote the repair and regeneration of damaged kidney tissue [ 68 ] .…”

Section: Urological Disorders and Uscsmentioning

confidence: 99%

Power of pee: Urine‐derived stem cells in urological disorders

Opara

Zhang

2023

UroPrecision

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Given that urine-derived stem cells (USCs) originate from the urinary tract system, they hold great potential for treating urological disorders. USCs have several advantages over other types of stem cells, such as easy and noninvasive collection, and abundant supply. USCs can differentiate into different types of cells. This makes them a potential source of cells for tissue engineering and regenerative medicine in the field of urology. In animal models, USCs or USCderived exosomes regenerate damaged tissues in the treatment of various urological disorders such as urinary incontinence, bladder dysfunction, interstitial cystitis, urethra injury erectile dysfunction, and kidney injury via multiple differentiation potential, angiogenesis, anti-inflammatory, paracrine effects, and immune modulation capability. Overall, the use of USCs in urological disorders is a rapidly developing field, and ongoing research is needed to fully understand their potential applications. However, the early results are promising and suggest that USCs could become a valuable cell source for the treatment of various urological disorders in the future.

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Locally transplanted human urine-induced nephron progenitor cells contribute to renal repair in mice kidney with diabetic nephropathy

Cited by 6 publications

References 31 publications

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

Renal-Protective Roles of Lipoic Acid in Kidney Disease

Power of pee: Urine‐derived stem cells in urological disorders

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