Locally measured microstructural parameters are better associated with vertebral strength than whole bone density

Hazrati, Javad; Eckstein, F.; Kühn, Volker; Ito, Keita; Cataldi, Matteo; Taddei, Fulvia; Rietbergen, Bert van

doi:10.1007/s00198-013-2591-3

Cited by 17 publications

(19 citation statements)

References 53 publications

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“…Meshing was done using secondorder tetrahedron elements with a typical size of 2 mm; the number of elements on the proximal femur models varied from approximately 80,000 to 90,000 depending on the scan length. For all elements at the cortical/cancellous region, we calculated a bone volume fraction (BV/TV) and fabric tensor M as described earlier (Hazrati Marangalou et al 2014a. In summary, for the elements that were at least partly within the cancellous bone, a spherical region around the element centroid with a diameter of 4 mm was defined (Harrigan et al 1988) and the mean intercept length (MIL)-based fabric tensor was calculated for that spherical volume of interest using the image processing software provided by micro-CT system.…”

Section: Methodsmentioning

confidence: 99%

A novel approach to estimate trabecular bone anisotropy from stress tensors

Hazrati

Ito

Rietbergen

2014

Biomech Model Mechanobiol

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Continuum finite element (FE) models of bones and bone-implant configurations are usually based on clinical CT scans. In virtually all of these models, material properties assigned to the bone elements are chosen as isotropic. It has been shown, however, that cancellous bone can be highly anisotropic and that its elastic behavior is best described as orthotropic. Material models have been proposed to derive the orthotropic elastic constants from measurements of density and a fabric tensor. The use of such relationships in FE models derived from CT scans, however, is hampered by the fact that the measurement of such a fabric tensor is not possible from clinical CT images since the resolution of such images is not good enough to resolve the trabecular micro-architecture. In this study, we explore an alternative approach that is based on the paradigm that bone adapts its micro-architecture to the loading conditions, hence that fabric and stress tensors should be aligned and correlated. With this approach, the eigenvectors and eigenvalues of the element continuum-level stress tensor are used as an estimate of the element fabric tensor, from which the orthotropic material properties then are derived. Using an iterative procedure, element orthotropic material properties and fabric tensors are updated until a converged situation is reached. The goals of this study were to investigate the feasibility and accuracy of such an iterative approach to derive orthotropic material properties for a human proximal femur and to investigate whether models derived in this way can provide more accurate results than isotropic models. Results were com- pared to those obtained from models of the same femurs for which the fabric was measured from micro-CT scans. It was found that the iterative approach could well estimate the orientation of the fabric principal directions. When comparing the stress/damage values in the models with material properties based on estimated and measured fabric tensors, the differences were not significant, suggesting that the material properties based on the estimated fabric tensor well reflected those based on the measured fabric tensor. Errors were less than those obtained when using isotropic models. It is concluded that this novel approach can provide a reasonable estimate of anisotropic material properties of cancellous bone. We expect that this approach can lead to more accurate results in particular for models used to study implants, which are usually anchored in highly anisotropic cancellous bone regions.

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Section: Methodsmentioning

confidence: 99%

A novel approach to estimate trabecular bone anisotropy from stress tensors

Hazrati

Ito

Rietbergen

2014

Biomech Model Mechanobiol

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“…First, these results mean that the trabecular component is definitely the primary factor to explain vertebral strength. Previous studies have proven that vertebral strength is mainly dependent on trabecular bone [14,[31][32][33]. Lu et al conducted mechanical compression tests of T12 vertebrae in elderly women (N = 20, average age: 80 years), and they reported that the factor that was most correlated with failure load was Tb.vBMD (Pearson's correlation coefficient, r = 0.66), whereas the correlation with Ct.Th was low (r = 0.35) [14].…”

Section: Discussionmentioning

confidence: 99%

Correlation between vertebral bone microstructure and estimated strength in elderly women: An ex-vivo HR-pQCT study of cadaveric spine

Yamada

Chiba

Okazaki

et al. 2019

Bone

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Keywords:High-resolution peripheral quantitative computed tomography (HR-pQCT) Bone microstructure Estimated bone strength Vertebral body A B S T R A C TPurpose: A vertebral fracture is the most common complication of osteoporosis, and various factors are involved in its occurrence. The purpose of this study was to investigate the role of trabecular and cortical bone microstructure on vertebral strength using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods: Three female cadaveric spines were investigated (average age: 80.3 years). The whole spine (T1-L4) was scanned by second-generation HR-pQCT at a voxel size of 60.7 μm. Bone microstructure analysis and micro finite element analysis were performed after excluding the upper and lower endplates and posterior elements of a total of 48 vertebrae. Correlations between trabecular and cortical bone microstructure parameters and estimated vertebral strength were analyzed by univariate and multivariate regression models. Results: Cortical thickness (Ct.Th) and trabecular thickness (Tb.Th) were strongly correlated with estimated failure load on univariate analysis (r = 0.89, 0.82). Trabecular volumetric bone mineral density (Tb.vBMD), bone volume fraction (BV/TV), trabecular number (Tb.N), and Ct.Th were correlated with estimated failure load on multivariate regression analysis. Conclusions: It was suggested that, in addition to trabecular bone (Tb.vBMD, BV/TV, Tb.N), cortical bone (Ct.Th) contributed significantly to vertebral strength in elderly women.

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“…al. [ 15 – 18 ] determined the bone volume fraction (BV/TV) and other microstructural parameters of bone from bone medical images using a mapping algorithm. The bone volume fraction (BV/TV) map [ 17 ], which is a measure of bone material density distribution, obtained from a CT image of the proximal portion of a femur is shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

Direct Bio-printing with Heterogeneous Topology Design

Ahsan

Xie

Khoda

2017

Procedia Manufacturing

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Bio-additive manufacturing is a promising tool to fabricate porous scaffold structures for expediting the tissue regeneration processes. Unlike the most traditional bulk material objects, the microstructures of tissue and organs are mostly highly anisotropic, heterogeneous, and porous in nature. However, modelling the internal heterogeneity of tissues/organs structures in the traditional CAD environment is difficult and oftentimes inaccurate. Besides, the de facto STL conversion of bio-models introduces loss of information and piles up more errors in each subsequent step (build orientation, slicing, tool-path planning) of the bio-printing process plan. We are proposing a topology based scaffold design methodology to accurately represent the heterogeneous internal architecture of tissues/organs. An image analysis technique is used that digitizes the topology information contained in medical images of tissues/organs. A weighted topology reconstruction algorithm is implemented to represent the heterogeneity with parametric functions. The parametric functions are then used to map the spatial material distribution. The generated information is directly transferred to the 3D bio-printer and heterogeneous porous tissue scaffold structure is manufactured without STL file. The proposed methodology is implemented to verify the effectiveness of the approach and the designed example structure is bio-fabricated with a deposition based bio-additive manufacturing system.

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Locally measured microstructural parameters are better associated with vertebral strength than whole bone density

Cited by 17 publications

References 53 publications

A novel approach to estimate trabecular bone anisotropy from stress tensors

A novel approach to estimate trabecular bone anisotropy from stress tensors

Correlation between vertebral bone microstructure and estimated strength in elderly women: An ex-vivo HR-pQCT study of cadaveric spine

Direct Bio-printing with Heterogeneous Topology Design

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