Locally Advanced Prostate Cancer: Three-Dimensional Magnetic Resonance Spectroscopy to Monitor Prostate Response to Therapy

Valentini, Anna Lia; Gui, Benedetta; D’Agostino, Giuseppe; Mattiucci, Gian Carlo; Clementi, Valeria; Molfetta, Ippolita Valentina Di; Bonomo, Pierluigi; Mantini, Giovanna

doi:10.1016/j.ijrobp.2011.12.089

Cited by 13 publications

(15 citation statements)

References 22 publications

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“…The use of an ERC is essential for spectroscopic imaging even at high field strength, because it increases SNR by a factor of 10, which results in higher spatial and spectral resolution [ 88 ]. It is known that Cit and polyamine spectral peaks decrease rapidly and progressively over time after EBRT or ADT, at a faster rate than Cho and Cr levels [ 89 ], because Cit is a biomarker of healthy cells which go first into apoptosis than cancerous cells. Thus, measuring the levels of Cit in these patients is of limited use for the identification of cancer recurrence.…”

Section: Multiparametric-mri After Radiation Therapymentioning

confidence: 99%

Multiparametric MRI for Recurrent Prostate Cancer Post Radical Prostatectomy and Postradiation Therapy

Barchetti

Panebianco

2014

BioMed Research International

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The clinical suspicion of local recurrence of prostate cancer (PCa) after radical prostatectomy (RP) and after radiation therapy (RT) is based on the onset of biochemical failure. The aim of this paper was to review the current role of multiparametric-MRI (mp-MRI) in the detection of locoregional recurrence. A systematic literature search using the Medline and Cochrane Library databases was performed from January 1995 up to November 2013. Bibliographies of retrieved and review articles were also examined. Only those articles reporting complete data with clinical relevance for the present review were selected. This review article is divided into two major parts: the first one considers the role of mp-MRI in the detection of PCa local recurrence after RP; the second part provides an insight about the impact of mp-MRI in the depiction of locoregional recurrence after RT (interstitial or external beam). Published data indicate an emerging role for mp-MRI in the detection and localization of locally recurrent PCa both after RP and RT which represents an information of paramount importance to perform focal salvage treatments.

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Section: Multiparametric-mri After Radiation Therapymentioning

confidence: 99%

Multiparametric MRI for Recurrent Prostate Cancer Post Radical Prostatectomy and Postradiation Therapy

Barchetti

Panebianco

2014

BioMed Research International

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“…Functional MRI techniques using DWI and choline metabolism have been evaluated for monitoring therapy response with varying results [9,10]. The variable sensitivity of [ 11 C]choline-PET/CT in identifying intraprostatic lesions [11,12] and its high cost make it essential that a prospective feasibility study is carried out.…”

Section: Introductionmentioning

confidence: 99%

Exploring the potential of [11C]choline-PET/CT as a novel imaging biomarker for predicting early treatment response in prostate cancer

Challapalli

Barwick²,

Tomasi³

et al. 2014

Nuclear Medicine Communications

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“…[181] Molecular atrophy, defined by Cho and citrate peak area-to-noise-ratio <5:1, is known to occur after RT and negatively correlates with PSA levels/response. [182] After RT, addition of MRSI to T2-weighted MRI improved the diagnostic accuracy of questionable recurrent lesions. [183] Furthermore, the total Cho-to-Cr ratio (tCho/Cr) from biopsy samples was reported to predict high risk versus indolent disease (2.4 ± 0.4 versus 1.5 ± 0.2) with an accuracy of 95% and may help stratify individual risk and select patients in need of salvage therapy.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

The Use of Quantitative Imaging in Radiation Oncology: A Quantitative Imaging Network (QIN) Perspective

Press

Shu

Shim

et al. 2018

International Journal of Radiation Oncology*Biology*Physics

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Modern radiation therapy is delivered with great precision, in part by relying on high-resolution multidimensional anatomic imaging to define targets in space and time. The development of quantitative imaging (QI) modalities capable of monitoring biologic parameters could provide deeper insight into tumor biology and facilitate more personalized clinical decision-making. The Quantitative Imaging Network (QIN) was established by the National Cancer Institute to advance and validate these QI modalities in the context of oncology clinical trials. In particular, the QIN has significant interest in the application of QI to widen the therapeutic window of radiation therapy. QI modalities have great promise in radiation oncology and will help address significant clinical needs, including finer prognostication, more specific target delineation, reduction of normal tissue toxicity, identification of radioresistant disease, and clearer interpretation of treatment response. Patient-specific QI is being incorporated into radiation treatment design in ways such as dose escalation and adaptive replanning, with the intent of improving outcomes while lessening treatment morbidities. This review discusses the current vision of the QIN, current areas of investigation, and how the QIN hopes to enhance the integration of QI into the practice of radiation oncology.

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Locally Advanced Prostate Cancer: Three-Dimensional Magnetic Resonance Spectroscopy to Monitor Prostate Response to Therapy

Cited by 13 publications

References 22 publications

Multiparametric MRI for Recurrent Prostate Cancer Post Radical Prostatectomy and Postradiation Therapy

Multiparametric MRI for Recurrent Prostate Cancer Post Radical Prostatectomy and Postradiation Therapy

Exploring the potential of [11C]choline-PET/CT as a novel imaging biomarker for predicting early treatment response in prostate cancer

The Use of Quantitative Imaging in Radiation Oncology: A Quantitative Imaging Network (QIN) Perspective

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