Locally Advanced Non-Small Cell Lung Cancer and Small Cell Lung Cancer

Gomez, Daniel R.; Balter, Peter A; Liao, Zhongxing

doi:10.1007/174_2014_976

Cited by 1 publication

(2 citation statements)

References 13 publications

(14 reference statements)

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“…The available imaging data also led to some limitations to this study. An ITV concept (Gomez et al 2014) was used to define the clinical target volume, which suited the free breathing condition during the daily CBCT imaging and the use of the average CT for planning. The PTV was created according to the clinical guidelines for carbon ion therapy: a 3 mm margin was added around the iCTV, but the stomach and duodenum were removed from this volume.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the clinical delineations were used, which were performed on the planning CT by experienced radiation oncologists; the stomach and duodenum were delineated for the purpose of this study. The gross tumor volume (GTV) included lymph nodes and fat infiltration; the internal GTV (iGTV) encompassed the GTV on each respiratory phase of the 4D-CT. A 5 mm margin was applied to the iGTV (or GTV) to create the internal clinical target volume (iCTV) (Gomez et al 2014). The planning target volume (PTV) was created by adding a 3 mm margin to the iCTV; the stomach and duodenum were excluded from the PTV.…”

Section: Patients and Imagingmentioning

confidence: 99%

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Comparing the dosimetric impact of interfractional anatomical changes in photon, proton and carbon ion radiotherapy for pancreatic cancer patients

et al. 2017

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Radiotherapy using charged particles is characterized by a low dose to the surrounding healthy organs, while delivering a high dose to the tumor. However, interfractional anatomical changes can greatly affect the robustness of particle therapy. Therefore, we compared the dosimetric impact of interfractional anatomical changes (i.e. body contour differences and gastrointestinal gas volume changes) in photon, proton and carbon ion therapy for pancreatic cancer patients. In this retrospective planning study, photon, proton and carbon ion treatment plans were created for 9 patients. Fraction dose calculations were performed using daily cone-beam CT (CBCT) images. To this end, the planning CT was deformably registered to each CBCT; gastrointestinal gas volumes were delineated on the CBCTs and copied to the deformed CT. Fraction doses were accumulated rigidly. To compare planned and accumulated dose, dose-volume histogram (DVH) parameters of the planned and accumulated dose of the different radiotherapy modalities were determined for the internal gross tumor volume, internal clinical target volume (iCTV) and organs-at-risk (OARs; duodenum, stomach, kidneys, liver and spinal cord). Photon plans were highly robust against interfractional anatomical changes. The difference between the planned and accumulated DVH parameters for the photon plans was less than 0.5% for the target and OARs. In both proton and carbon ion therapy, however, coverage of the iCTV was considerably reduced for the accumulated dose compared with the planned dose. The near-minimum dose ([Formula: see text]) of the iCTV reduced with 8% for proton therapy and with 10% for carbon ion therapy. The DVH parameters of the OARs differed less than 3% for both particle modalities. Fractionated radiotherapy using photons is highly robust against interfractional anatomical changes. In proton and carbon ion therapy, such changes can severely reduce the dose coverage of the target.

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Section: Discussionmentioning

confidence: 99%

Section: Patients and Imagingmentioning

confidence: 99%