Locally Advanced Breast Cancer – Strategies for Developing Nations

Balogun, Onyinye; Formenti, Silvia C.

doi:10.3389/fonc.2015.00089

Cited by 22 publications

(18 citation statements)

References 40 publications

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“…The improvement in survival experienced in such centers is transforming BC to just another chronic illness with focus of management now shifting towards coping with long term survival. In contrast, BC remains a catastrophic illness in Low and Middle Income Centers (LMIC); the top 10 highest mortality rates from breast cancer are recorded in LMIC and Nigeria is third on the list (1). …”

Section: Introductionmentioning

confidence: 99%

Level of awareness and knowledge of breast cancer in Nigeria. A systematic review

Agodirin

Halimat

Samuel

et al. 2017

Ethiop J Health Sci

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Section: Introductionmentioning

confidence: 99%

Level of awareness and knowledge of breast cancer in Nigeria. A systematic review

Agodirin

Halimat

Samuel

et al. 2017

Ethiop J Health Sci

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“…Despite such advances, patients, particularly in low and middle income countries, are often faced with many challenges including the high cost and poor availability of treatments, as well as significant side effects associated with many conventional treatment modalities [ 2 ]. Furthermore, a significant proportion of these patients are diagnosed at an advanced stage of the disease when conventional therapies have limited benefit [ 3 ]. The dissatisfaction, skepticism, and poor availability of conventional cancer treatments were suggested to drive a considerable proportion of patients to seek and explore alternative modalities for the treatment of their disease [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Complementary and alternative medicine use and its association with quality of life among Lebanese breast cancer patients: a cross-sectional study

Naja

Fadel

Alameddine

et al. 2015

BMC Complement Altern Med

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BackgroundBreast cancer patients are increasingly seeking Complementary and Alternative Medicine (CAM) therapies with the hope of alleviating the burden of the disease and improving their quality of life (QOL). The objective of this study was to assess the prevalence, types, socio-demographic and disease-related correlates as well as characteristics of CAM use (including disclosure to treating physicians) among breast cancer patients in Beirut, Lebanon. A secondary objective was to evaluate the association between CAM use and QOL.MethodsA cross-sectional survey was conducted on breast cancer patients recruited from two major referral centers in Beirut: a philanthropic hospital and a private academic medical center. In face-to-face interviews, participants completed a questionnaire of three sections: socio-demographic and lifestyle characteristics, breast cancer condition, and CAM use. Three to four weeks following these interviews, the secondary QOL assessment was carried out via telephone using the Arabic version of the Functional Assessment of Cancer Therapy-Breast questionnaire. The main outcome in this study, CAM use, was defined as using CAM at least once after breast cancer diagnosis.ResultsA total of 180 breast cancer patients completed the survey (response rate: 94.6 %). Prevalence of CAM use was 40 %. Using multivariate logistic regression, CAM use was negatively associated with age (OR: 0.96, CI: 0.92-0.99), treatment at the philanthropic hospital (OR: 0.13, CI: 0.05-0.35) and was positively associated with an advanced stage of the disease (OR: 4.20, CI: 1.65-10.69). Among study participants recruited from both sites, the most commonly used CAM was ‘special food’ followed by ‘herbal teas’, ‘diet supplements’ and ‘Spiritual healing’. Only 4 % of CAM users cited health professionals as influencing their choice of CAM and only one in four patients disclosed CAM use to their treating physician. There was no significant association between CAM use and QOL.ConclusionsThe findings of this study revealed a prevalent CAM use among Lebanese breast cancer patients. Furthermore, physicians’ role in orienting CAM use was found to be marginal as patients relied mainly on family and media for their choice of CAM and were less likely to disclose CAM use to their treating physicians.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-015-0969-9) contains supplementary material, which is available to authorized users.

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“…However, one of the major problems associated with this cancer type is that the strong side effects of the treatment still cause severe discomfort to the patients. [ 5 ]. Therefore, breast cancer prevention and treatment programs aim to identify more efficient and precise diagnostic and prognostic markers, as well as targets for a treatment with milder side effects [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…[ 5 ]. Therefore, breast cancer prevention and treatment programs aim to identify more efficient and precise diagnostic and prognostic markers, as well as targets for a treatment with milder side effects [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma

et al. 2015

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Glycolytic enzymes, such as hexokinase and phosphofructokinase, have been reported to be upregulated in many cancer types. Here, we evaluated these two enzymes in 54 breast cancer samples collected from volunteers subjected to mastectomy, and the results were correlated with the prognosis markers commonly used. We found that both enzymes positively correlate with the major markers for invasiveness and aggressiveness. For invasiveness, the enzymes activities increase in parallel to the tumor size. Moreover, we found augmented activities for both enzymes when the samples were extirpated from patients presenting lymph node involvement or occurrence of metastasis. For aggressiveness, we stained the samples for the estrogen and progesterone receptors, HER-2, p53 and Ki-67. The enzyme activities positively correlated with all markers but Ki-67. Finally, we conclude that these enzymes are good markers for breast cancer prognosis.

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Locally Advanced Breast Cancer – Strategies for Developing Nations

Cited by 22 publications

References 40 publications

Level of awareness and knowledge of breast cancer in Nigeria. A systematic review

Level of awareness and knowledge of breast cancer in Nigeria. A systematic review

Complementary and alternative medicine use and its association with quality of life among Lebanese breast cancer patients: a cross-sectional study

Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma

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