Locally acquired hepatitis E virus in Marche Italy: Clinical/laboratory features and outcome

Tarantino, Giuseppe; Ortolani, Alessio; Marinelli, Katia; Benedetti, Antonio; Marconi, Giancarlo; Calzolari, Manuela; Dalton, Harry R.; Marzioni, Marco; Schiadà, Laura; Fava, Giammarco; Chiodera, Alessandro; Amadio, Giorgio; Fiorentini, Alessandro; Riva, Alessandra; Fraticelli, Paolo; Menzo, Stefano; Bagnarelli, Patrizia

doi:10.1016/j.dld.2019.11.015

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…Clinical outcome data and reported risk factors in our cohort were in line with those of previous studies. [5][6][7][8]10,31 Extrahepatic manifestations were reported for 8•4% patients with a clear predominance of neurological symptoms, which is similar to other studies. 4,7 These included Guillain-Barre's, Parsonage-Turner's and Miller Fischer syndromes as well as undetermined J o u r n a l P r e -p r o o f acute poly(radiculo)neuropathy for 23•5%, 11•8%, 5•9% and 41•2% of the patients with neurologic symptoms, respectively.…”

Section: Discussionsupporting

confidence: 90%

Viral clade is associated with severity of symptomatic genotype 3 hepatitis E virus infections in Belgium, 2010–2018

Peeters

Schenk²,

Somer³

et al. 2023

Journal of Hepatology

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Section: Discussionsupporting

confidence: 90%

Viral clade is associated with severity of symptomatic genotype 3 hepatitis E virus infections in Belgium, 2010–2018

Peeters

Schenk²,

Somer³

et al. 2023

Journal of Hepatology

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“…In addition to chronic liver disease, this study also examined the impact of chronic diseases (coronary heart disease, hypertension, and DM) on the progression of hepatitis E patients to liver failure. It found that patients with DM rather than SLD were more likely to progress to liver failure, which is consistent with the findings of Tarantino et al [30]. This study did not find evidence of an additive interaction between DM and SLD on the risk of liver failure in hepatitis E patients.…”

Section: Discussionsupporting

confidence: 92%

Clinical characteristics of 1279 patients with hepatitis E in Tianjin

Yang,

Wen,

Zhang

et al. 2023

Epidemiol. Infect.

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Hepatitis E virus infection is a major cause of acute hepatitis, typically self-limiting but occasionally leading to liver failure. Understanding disease progression factors could inform prevention strategies. This study aimed to analyse the characteristics of a large cohort of hospitalised hepatitis E patients in Tianjin, China, and explore factors influencing their progression to liver failure. A total of 1279 hospitalised patients with hepatitis E were included in this cross-sectional study in Tianjin, China. Student's t-test and the Mann–Whitney U-test were used for comparisons. Multiple logistic regression analysis was used to explore the association. Among these 1279 patients, 107 (8.4%) developed liver failure. Patients with diabetes mellitus (DM) (95% confidence interval [CI] 1.150–2.887, p = 0.011), liver cirrhosis (95% [CI] 2.229–7.224, p < 0.001), and hepatitis B (95% [CI] 1.159–4.512, p = 0.017) were more likely to progress to liver failure. Hepatitis E patients with comorbid DM, liver cirrhosis, or hepatitis B virus co-infection have higher risks of developing liver failure. Hepatitis E vaccination may be recommended for these vulnerable patients to curb disease severity.

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“…Similarly, in a retrospective collection of HEV cases in the Marche Region, mortality rate was as high as 8%, death and hospitalization being associated with older age and severe comorbidities but related also with delay in diagnosis [21].…”

Section: N Discussionmentioning

confidence: 94%

Prevalence of HEV infection in acute non-ABC hepatitis and prognostic role of extrahepatic manifestations

et al. 2023

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Background: HEV-3 and HEV-4 are emerging cause of zoonotic acute hepatitis in high-income countries. In Europe the disease is underdiagnosed but hyperendemic areas have been identified. We describe a population with acute non-ABC (n-ABC) hepatitis in Abruzzo, the Italian region with the highest seroprevalence reported. The study was included in the surveillance of acute hepatitis E by the Italian Institute of Public Health started in 2004 and implemented in 2015. Methods: Patients with n-ABC hepatitis during 2004-2018 in all Abruzzo Infectious Disease Departments were tested for HEV-IgM (Wantai ® ) and HEV-RNA (ORF3). Positive samples were sequenced (Beckman Coulter ® ) and phylogenetic tree (MEGA 6.06 software) obtained. Clinical data were retrospectively collected and an alimentary risk factors-questionnaire was administered. Categorical and quantitative variables were compared (Chi square test or Fisher test and Wilcoxon test). Results: 97 hospitalized patients were tested, most cases (91.7%) after 2015. Overall, HEV-IgM resulted positive in 36% and HEV-RNA detectable in 33.3%. All 24 sequences obtained were HEV-3, with two small groups of closely related strands. L'Aquila was the Province with higher positivity rate (44%). Retrospective clinical data were acquired in 86.5% of patients, no one having liver failure. Higher ALT-levels (1282.34 vs 893.25, p=0.0139) and extrahepatic symptoms (OR 16.69, p=0.0018) were strongly associated with HEV-IgM presence. Two small outbreaks are described. Conclusions: More than one third of n-ABC hepatitis in all Abruzzo are HEV-related. Extrahepatic symptoms correlate with HEV aetiology. Implementing surveillance is mandatory to really understand the extent of the disease.

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Locally acquired hepatitis E virus in Marche Italy: Clinical/laboratory features and outcome

Cited by 4 publications

References 33 publications

Viral clade is associated with severity of symptomatic genotype 3 hepatitis E virus infections in Belgium, 2010–2018

Viral clade is associated with severity of symptomatic genotype 3 hepatitis E virus infections in Belgium, 2010–2018

Clinical characteristics of 1279 patients with hepatitis E in Tianjin

Prevalence of HEV infection in acute non-ABC hepatitis and prognostic role of extrahepatic manifestations

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