Abstract:Spectrin, the major protein of the RBC membrane skeleton has canonically been thought to only serve a structural function. We have described a novel chaperone-like property of spectrin and have shown that it is able to prevent the aggregation of other proteins such as alcohol dehydrogenase, insulin and free globin chains. We have tried to localize the molecular origin of chaperonelike activity in multi-domain spectrin by using recombinant spectrin fragments and investigating individual domains. We have charact… Show more
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