Localized Xanthomas Associated with Primary Lymphedema

Romaní, Jorge; Luelmo, Jesús; Sáez, Amparo; Yébenes, Mireia; Sàbat, Mireia; Fernández-Chico, Natalia; Pifarré, Montserrat; García, Daniel; Muñoz, Camilo

doi:10.1111/j.1525-1470.2011.01686.x

Cited by 13 publications

(11 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The efflux of cholesterol from peripheral tissues to systemic circulation through lymphatic vessels is not passive, but an active process could dependent on uptake and transcytosis of HDL by scavenger receptor class B type 1 (SR-B1) expressed on LECs (Lim et al, 2013). This concept is supported by the fact that patients with primary lymphedema often display xanthomas (cholesterol-rich deposits in the skin) (Berger et al, 1972;Romani et al, 2012). Poor lymphatic function in primary lymphedema causing increased cholesterol accumulation might contribute to fat deposition, a major symptom of lymphedema.…”

Section: Lymphatic Function In Hypercholesterolemia and MImentioning

confidence: 99%

Regulation of Lymphatic Function in Obesity

et al. 2020

View full text Add to dashboard Cite

The lymphatic system has many functions, including macromolecules transport, fat absorption, regulation and modulation of adaptive immune responses, clearance of inflammatory cytokines, and cholesterol metabolism. Thus, it is evident that lymphatic function can play a key role in the regulation of a wide array of biologic phenomenon, and that physiologic changes that alter lymphatic function may have profound pathologic effects. Recent studies have shown that obesity can markedly impair lymphatic function. Obesity-induced pathologic changes in the lymphatic system result, at least in part, from the accumulation of inflammatory cells around lymphatic vessel leading to impaired lymphatic collecting vessel pumping capacity, leaky initial and collecting lymphatics, alterations in lymphatic endothelial cell (LEC) gene expression, and degradation of junctional proteins. These changes are important since impaired lymphatic function in obesity may contribute to the pathology of obesity in other organ systems in a feedforward manner by increasing low-grade tissue inflammation and the accumulation of inflammatory cytokines. More importantly, recent studies have suggested that interventions that inhibit inflammatory responses, either pharmacologically or by lifestyle modifications such as aerobic exercise and weight loss, improve lymphatic function and metabolic parameters in obese mice. The purpose of this review is to summarize the pathologic effects of obesity on the lymphatic system, the cellular mechanisms that regulate these responses, the effects of impaired lymphatic function on metabolic syndrome in obesity, and the interventions that may improve lymphatic function in obesity.

show abstract

Section: Lymphatic Function In Hypercholesterolemia and MImentioning

confidence: 99%

Regulation of Lymphatic Function in Obesity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[4] Since then, there have been few reports of few small xanthomatous lesions in a localized area. [56] As explained earlier because of defective embryogenesis, there is increased leakiness. An altered pressure gradient between intralymphatic and extralymphatic compartments may occur because of infection, trauma, and invasive procedure.…”

Section: Discussionmentioning

confidence: 99%

Giant and extensive localized xanthoma associated with primary lymphedema

Sharma

Gupta

2019

Indian J Dermatol

View full text Add to dashboard Cite

Lymphedema is extravasation of lymphatic fluid into extracellular spaces and may be primary or secondary. Primary lymphedema may be caused by truncular lymphatic malformation. Long-standing lymphedema may result in various complications due to increased porosity of lymphatics, defective valves, and increased lymphatic pressure. There are few reports of normolipidemic xanthoma in association with lymphedema. We report a case of giant xanthoma associated with primary lymphedema.

show abstract

“…Even though most cutaneous xanthomas are associated with hyperlipidemia, VXs are often not linked to the disorders of lipid metabolism. 6 …”

Section: Discussionmentioning

confidence: 99%