Localized vulvar bullous pemphigoid of childhood: A rare cause of persistent vulvar erosions in children

Abstract

Localized vulvar bullous pemphigoid of childhood is an excessively rare variant of bullous pemphigoid and affects almost exclusively young girls of 7-12 years of age. In contrast to adult-onset bullous pemphigoid, a prompt response to potent topical corticosteroids is observed in the majority of cases, with a favorable prognosis and rare relapses. We report the case of a 7-year-old girl who presented with this condition.Our case reinforces the recognition of this rare subtype of childhood bullous pemphigoid as a distinct entity and enlightens the importance of performing a cutaneous biopsy when clinically indicated. K E Y W O R D S bullous disease, bullous pemphigoid, immunobullous disease, mucous membrane disorders, vesiculobullous disorders, vulvar disorders How to cite this article: Belzile E, Funaro D, Powell J. Localized vulvar bullous pemphigoid of childhood: A rare cause of persistent vulvar erosions in children. Pediatr Dermatol.

Bullous Pemphigoid in Children: Clinical Presentation, Pathology and Management

“…In the childhood form tense bullae coexist with urticarial plaques; however there appears to be more involvement of the face and external genitalia. These findings were reported by Belzile, Erbagci and Chou for children with an age range of 20 months to 12 years old [4,8,9]. Erbagci described the involvement of the vulva, perianal region in addition to the groins and flexures in their reported case [8].…”

“…The childhood form peaks around the age of 8 and has a less uniform presentation of lesions with a higher involvement of the external genitalia in up to 44% of cases [4]. The two key distinguishing features of childhood BP from adulthood BP include acral involvement and mucous membrane involvement [5].…”

Juvenile and adult vulvar pemphigoid, an under recognized entity: Case series of fourteen patients

“…[2][3][4][5] Two variants can be distinguished: the juvenile form presenting in girls between 5 and 10 years old, and the adult form, which occurs mainly in postmenopausal women. 6,7 However, symptoms may also occur in patients within these two age categories. Overlapping with other chronic vulvar diseases, VP can present with variable clinical and histopathologic features, including lichen sclerosus (LS) and erosive lichen planus affecting the vulva (ELPV).…”

Using Extra Virgin Olive Oil (Evoo) as a Therapy in Angular Cheilitis: Current Scientific Evidence is Rediscovering Our Grandparents’ Ancient Tradition

“…The literature describes several cases in which Extra Virgin Olive Oil (EVOO) is used, such as in cases of mucositis following chemotherapy [4], xerostomia and burning mouth syndrome [5,6], in the prevention of initial enamel erosion [7], in the treatment of major traumatic ulcers [8].…”