Localized Tissue Surrogate Deformation due to Controlled Single Bubble Cavitation

Yang, Hong; Sarntinoranont, Malisa; Canchi, Saranya; King, Michael A.; Subhash, Ghatu

doi:10.21236/ada616690

Cited by 8 publications

(13 citation statements)

References 36 publications

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“…As the shockwave scatters from the proximal cloud surface, a new section of the cloud is generated with each cycle. Shockwave-induced cavitation (SIC), a broad subsection that includes AIC, techniques include drop tower (41), Split-Hopkinson or Kolsky bar (4,8), and controlled blast (87) setups. Confinement-induced cavitation.…”

Section: A B Cmentioning

confidence: 99%

Cavitation in soft matter

Barney

Dougan

McLeod

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

111

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Cavitation is the sudden, unstable expansion of a void or bubble within a liquid or solid subjected to a negative hydrostatic stress. Cavitation rheology is a field emerging from the development of a suite of materials characterization, damage quantification, and therapeutic techniques that exploit the physical principles of cavitation. Cavitation rheology is inherently complex and broad in scope with wide-ranging applications in the biology, chemistry, materials, and mechanics communities. This perspective aims to drive collaboration among these communities and guide discussion by defining a common core of highpriority goals while highlighting emerging opportunities in the field of cavitation rheology. A brief overview of the mechanics and dynamics of cavitation in soft matter is presented. This overview is followed by a discussion of the overarching goals of cavitation rheology and an overview of common experimental techniques. The larger unmet needs and challenges of cavitation in soft matter are then presented alongside specific opportunities for researchers from different disciplines to contribute to the field. soft solids | traumatic brain injury | TBI | rheology | bubble Cavitation is the sudden, unstable expansion of a void or bubble within a liquid or solid subjected to a negative hydrostatic stress. While predominantly studied in fluids, cavitation is also an origin of damage in soft materials, including biological tissues. Examples of cavitation in fluids and soft solids are shown in Fig. 1 A-C. As one key example, strong evidence suggests that cavitation occurs in the brain during sudden impacts, leading to traumatic brain injury (TBI) (3). Research on this life-impacting injury and its relation to cavitation has accelerated in recent years (4-8). A broader and deeper understanding of cavitation within soft matter is necessary to navigate the complex paths that lead to damage in the brain and other soft materials. Cavitation in fluids has been studied extensively since Rayleigh's (9) formulation in 1917, which predicted that the maximum pressure in a cavitating liquid is proportional to the far-field pressure and inversely proportional to the cavity size. As surface energy

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Section: A B Cmentioning

confidence: 99%

Cavitation in soft matter

Barney

Dougan

McLeod

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

111

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“…during brain injury, a number of challenges have impeded the controlled study of these bubbles in viscoelastic media. In particular, generating single, spherical bubbles at precisely controlled locations using transient acoustic pulses [8,34] is difficult to accomplish without modifying the media, for example, by injecting gas microbubbles or inserting point defects in the media [35].…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the dynamics of laser and acoustically generated bubbles in viscoelastic media

et al. 2019

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Experimental observations of the growth and collapse of acoustically and laser-nucleated single bubbles in water and agarose gels of varying stiffness are presented. The maximum radii of generated bubbles decreased as the stiffness of the media increased for both nucleation modalities, but the maximum radii of laser-nucleated bubbles decreased more rapidly than acoustically nucleated bubbles as the gel stiffness increased. For water and low stiffness gels, the collapse times were well predicted by a Rayleigh cavity, but bubbles collapsed faster than predicted in the higher stiffness gels. The growth and collapse phases occurred symmetrically (in time) about the maximum radius in water but not in gels, where the duration of the growth phase decreased more than the collapse phase as gel stiffness increased. Numerical simulations of the bubble dynamics in viscoelastic media showed varying degrees of success in accurately predicting the observations.

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“…These results, along with several other experiments on human brain surrogates of ranging realism demonstrating the existence of cavitation at pressures around -1 atmospheres (or roughly -100 kPa), are pointing to suggestive evidence that microcavitation might indeed be a possible injury mechanism of not just blast but also possibly blunt head trauma [13,20,22,23]. Works by several groups have shown that pressures near the estimated cavitation threshold of -1 atmosphere can be generated in head impacts sustained from sports-related or vehicular incidents, even in the absence of an explosive pressure wave [24,25].…”

mentioning

confidence: 60%

“…However, increasing mounting evidence, in particular in the last few years, has provided us with a better understanding that inertial microcavitation in the brain might indeed be a real possibility [13,20–23]. For example, Goeller et al.…”

mentioning

confidence: 99%

“…To address this question, we turn to the laboratory where several researchers have begun to map out the injury pathology, stress and strain maps of cavitation-inflicted tissue and cell damage [20,23]. By incorporating advanced mechanical engineering models of cavitation alongside carefully executed in vitro experiments in brain surrogate materials, a glimpse of just how devastating cavitation can be on cells in the brain can be gleamed.…”

mentioning

confidence: 99%

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