Localized Tissue Destruction by High-Intensity Focused Ultrasound

Linke, Charles A.; Carstensen, Edwin L.; Frizzell, Leon A.; Elbadawi, Ahmad; Fridd, C.W.

doi:10.1001/archsurg.1973.01350240053015

Cited by 104 publications

(43 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…He also described lesions due to the reflection of ultrasound waves at the liver-air interfaces. Linke et al [9] observed a maximum lesion size the third day after the treatment, and its replacement by a thin fibrous scar after several months. In a quantitative and qualitative study, using a 1,8-MHz transducer on porcine liver in vitro, Ter Haar et al [16] showed that with increasing intensity at constant exposure time the lesion volume increased but was developing toward the liver sur face, in front of the focal plane.…”

Section: Experimental Studiesmentioning

confidence: 97%

See 1 more Smart Citation

Extracorporeal Ablation of Liver Tissue by High-Intensity Focused Ultrasound

et al. 1993

View full text Add to dashboard Cite

High-intensity focused ultrasound (HIFU) may produce a well-delineated lesion of coagulation necrosis in deep organs, by means of an extracorporeal transducer. Applications of this method to the liver in animal models have been studied for many years. The effects of HIFU on the normal liver parenchyma and on hepatic tumors are reviewed. In the normal rabbit liver in vivo we showed the relation between intensity levels and exposure times and the need to adapt intensity to the depth of the target. No severe complications were observed when an intensity of 1,000 W/cm² was used. HIFU is a noninvasive method for the local destruction of liver tumors. In experimental models, safety and efficacy were demonstrated. HIFU may be interesting for the treatment of some human liver tumors.

show abstract

Section: Experimental Studiesmentioning

confidence: 97%

“…There are several reports in the literature concerning the use of HIFU in liver tissue in different experimental models [7,9,16], in vivo or in vitro. The ability of HIFU to cause delineated irreversible tissue destruction in the liver has been well documented.…”

Section: Experimental Studiesmentioning

confidence: 99%

Extracorporeal Ablation of Liver Tissue by High-Intensity Focused Ultrasound

et al. 1993

View full text Add to dashboard Cite

show abstract

“…Previous studies suggest that differences may exist in the absorption coefficient between cortical and medullary structures in the kidney (Linke et al, 1973). As an attempt to determine if significant velocity differences exist between these two structures the mouse kidney was examined; however, it proved to be impossible to separate samples from these two regions in such a small kidney.…”

Section: Resultsmentioning

confidence: 99%

Measurement of ultrasonic velocity in several biological tissues

Frizzell

Gindorf

1981

Ultrasound in Medicine & Biology

View full text Add to dashboard Cite

Abstract--The ultrasonic velocity at 100MHz and room temperature (23-26°C) was measured in fresh, excised mammalian liver, kidney, spleen, and pancreas and mouse kidney. The results show excellent agreement with measurements at low MHz frequencies. A significant velocity difference is reported between kidney cortex and medulla, but no difference was observed between the exocrine and islets of Langerhans in the first measurements of velocity in the pancreas.

show abstract

“…For liver tumors, various thermoablation therapies using laser, 1 radio frequency, 2 microwave, 3 and focused ultrasound 4 have had promising results, comparable to those of surgical resection, especially in small tumors. Ultrasonography has been most commonly and conveniently used for image guidance because of its simplicity, portability, and safety, and microbubble-based contrast agents have been used eŠectively for diagnosis and ablation therapies.…”

Section: Introductionmentioning

confidence: 99%

Correlation between High Field MR Images and Histopathological Findings of Rat Transplanted Cancer Immediately after Partial Microwave Coagulation

et al. 2008

View full text Add to dashboard Cite

Purpose: To investigate the immediate eŠects of microwave coagulation on rat tumors in various magnetic resonance (MR) images at high magneticˆeld strength using histopathological examinations as reference.Materials and Methods: Tumors implanted in rat femurs were partially thermocoagulated by microwave. Immediately after, T 1 -and T 2 -weighted images, diŠusion-weighted images (DWIs), and contrast-enhanced T 1 weighted images (CE-T 1 WIs) were acquired with a 7-tesla MR scanner. After measurements, tumors were examined histopathologically with hematoxylin-eosin (HE) staining and histochemically for acid phosphatase activity.Results: Without contrast, boundaries of coagulated areas were unclear on MR images, including apparent diŠusion coe‹cient (ADC) maps. CE-T 1 WIs clearly showed immediate contrast enhancement of untreated areas of tumor, and the area of enhancement gradually enlarged in 5 min. Quantitative analyses were conducted by classifying tumor areas by contrast enhancement results. Signal intensities of the areas in the MR images showed no signiˆcant diŠerences, but at the periphery, ADC values were signiˆcantly higher in areas with delayed enhancement than those with immediate enhancement. Compared with histopathologicalˆndings, with microwave thermocoagulation, increased ADC value seemed to derive from collection of extracellular ‰uid in the outer zone, where acid phosphatase activity was attenuated.Conclusion: ADC values in the areas with delayed enhancement of CE-T 1 WIs were higher than those in non-aŠected areas, but MR images could not show areas of coagulation within tumors. Clear detection of the boundaries of coagulated areas required contrast enhancement, even at magneticˆeld strength of 7T.

show abstract

Localized Tissue Destruction by High-Intensity Focused Ultrasound

Cited by 104 publications

References 16 publications

Extracorporeal Ablation of Liver Tissue by High-Intensity Focused Ultrasound

Extracorporeal Ablation of Liver Tissue by High-Intensity Focused Ultrasound

Measurement of ultrasonic velocity in several biological tissues

Correlation between High Field MR Images and Histopathological Findings of Rat Transplanted Cancer Immediately after Partial Microwave Coagulation

Contact Info

Product

Resources

About