Localized Scleroderma: Predisposing and Triggering Factors

Хамаганова, И. В.

doi:10.2174/1874372201711010001

Cited by 5 publications

(10 citation statements)

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“…Some triggering factors such as vaccination, drugs, chemical substances, trauma, insect bites, sunburn, infections, radiation, autoimmunity and psychological stress may play a role in the etiopathogenesis of morphea (3,24). The presence of environmental factors was found in 13.3% (n=100) of the patients, 7.3% of which was traumatic (14).…”

Section: Methodsmentioning

confidence: 99%

“…Localized scleroderma (LS), which is also known as morphea, is a rare inflammatory skin disease, that causes sclerosis in the dermis and subcutaneous tissue. Although the exact underlying mechanisms have not been fully understood yet, many factors have been implicated in the etiopathogenesis of morphea (1)(2)(3). Morphea is more frequent in females and the incidence has been reported to be 0.4 to 2.7 % (1,2,(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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Lokalize Skleroderma Tanılı Çocuk Hastaların Klinik ve Demografik Özellikleri

Akbaş¹,

Kılınç²

2021

Turkish Journal of Pediatric Disease

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Objective: Localized scleroderma (LS), which is also called as morphea, is a rare skin disease with unknown etiology. LS is typically characterized by sclerosis in the dermis and the subcutaneous tissue. The number of retrospective studies examining the epidemiological, clinical and laboratory data of patients with juvenile LS in Turkey is very limited. The purpose of this study was to investigate the clinical and demographic characteristics of pediatric patients under the age of 18, who were followed up with a diagnosis LS, also to evaluate and compare these findings with available literature. Material and Methods: The medical records of 39 patients, who had been clinically and histopathologically diagnosed with LS and followed up in our clinic between 2012-2018, were retrospectively reviewed. Demographic, clinical and laboratory findings, and treatment options of the patients were recorded. Results: A total of 39 pediatric patients (8 boys, 31 girls, mean age 12.1 years) with LS were enrolled in the present study. The age at disease onset was 8.6 years. The mean duration of the disease was 3.6 years. The most common type was plaque type morphea. In two cases, there was movement restriction in the legs, and lichen sclerosus was concurrently present in another case. 12 patients had antinuclear antibody positivity, while 3 cases had positive Borrelia antibodies. Conclusion: Morphea has lifelong complications for children. Early diagnosis and monitoring of morphea in the childhood period is important in order to avoid both physical and psychological sequelae that may occur in the future.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lokalize Skleroderma Tanılı Çocuk Hastaların Klinik ve Demografik Özellikleri

Akbaş¹,

Kılınç²

2021

Turkish Journal of Pediatric Disease

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“…Предрасполагающими факторами локализованной склеродермии могут выступать внешние факторы (низкие температуры, инсоляция, ионизирующее излучение), инфекции (цитомегаловирус, ветряная оспа, вирус иммунодефицита человека) и травма [1,15,16].…”

Section: этиология и патогенезunclassified

Juvenile Localized Scleroderma from the Perspective of Pediatric Rheumatologist. Aspects of Diagnostics

Raupov

Имельбаев

Kostik

2020

Vopr. sovr. pediatr.

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The localized scleroderma (morphea) is the clinical option of the juvenile scleroderma, the third in prevalence rheumatic condition in pediatrics. The article summarizes all the data on the classification, diagnostics, and differential diagnosis of juvenile localized scleroderma. The recent international guidelines on the localized scleroderma in pediatrics (the European consensus of pediatric rheumatologists, the German and Japanese national guidelines) are presented in the article.

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“…Подобная полиморбидность свидетельствует о выраженных и взаимоотягощающих сосудистых изменениях. Кроме того, хорошо известно, что сахарный диабет может в ряде случаев предрасполагать как к развитию очаговой склеродермии, так и кольцевидной гранулемы [2,[5][6][7][8][9].…”

Section: рис 3 очаги поражения на туловище у пациентки асunclassified

“…Кроме того, необходимо отметить транснозологическую коморбидность (сосуществование у одного пациента двух и/или более заболеваний, патогенетически взаимосвязанных между собой) -развитие очаговой склеродермии и кольцевидной гранулемы у пациенток, страдающих артериальной гипертензией, обусловливающей ангиопатии и нарушения макро-и микроциркуляции [1]. Васкулярная патология является предрасполагающим фактором как к развитию очаговой склеродермии, так и кольцевидной гранулемы [2,11,12].…”

Section: рис 3 очаги поражения на туловище у пациентки асunclassified

Granuloma annulare in patients with localized scleroderma

Хамаганова¹,

Novoseltsev²,

Лебедева³

2018

Klin. dermatol. venerol.

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При очаговой склеродермии могут наблюдаться различные формы коморбидности. К неуточненной коморбидности относят те случаи, когда предполагается наличие единых механизмов развития болезней, составляющих общую клиническую картину, но для подтверждения этого тезиса требуется проведение определенных исследований [1]. В этой связи рассматривают сочетание очаговой склеродермии с эндокринными заболеваниями, вирусными и бактериальными инфекциями, онкологической патологией [2]. К неуточненной коморбидности можно отнести сочетание очаговой склеродермии и псориаза [3]. При «случайной» коморбидности «случайность» и кажущаяся алогичность данных комбинаций в

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Localized Scleroderma: Predisposing and Triggering Factors

Cited by 5 publications

References 82 publications

Lokalize Skleroderma Tanılı Çocuk Hastaların Klinik ve Demografik Özellikleri

Lokalize Skleroderma Tanılı Çocuk Hastaların Klinik ve Demografik Özellikleri

Juvenile Localized Scleroderma from the Perspective of Pediatric Rheumatologist. Aspects of Diagnostics

Granuloma annulare in patients with localized scleroderma

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