Localized pruritus: A presenting symptom of a spinal cord tumor in a child with features of neurofibromatosis

Johnson, Robert E.; Kanigsberg, Nordau; Jimenez, Carmencita

doi:10.1016/s0190-9622(00)70234-9

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…These mast cells undergo rapid growth in these tumors and, consequently, release histamine, a substance known to cause itching5. Localized pruritus can also be a clue to the presence of an underlying spinal cord or central nervous tumor67.…”

Section: Cutaneous Manifestationsmentioning

confidence: 99%

Neurofibromatosis type 1

Boyd¹,

Korf²,

Theos³

2009

Journal of the American Academy of Dermatology

436

365

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Neurofibromatosis type 1 (NF1) is an autosomal dominant, multisystem disorder affecting approximately 1 in 3500 people. Significant advances in the understanding of the pathophysiology of NF1 have been made in the last decade. While no medical therapies are currently available, trials are ongoing to discover and test medical treatments for the various manifestations of NF1, primarily plexiform neurofibromas, learning disabilities, and optic pathway gliomas. Additionally, mutational analysis has become available on a clinical basis and is useful for diagnostic confirmation in individuals who do not fulfill diagnostic criteria or when prenatal diagnosis is desired. There are several disorders which may share overlapping features with NF1; in 2007, a disorder with cutaneous findings similar to NF1 was described. This paper addresses the dermatologist's role in diagnosis and management of NF1 and describes the variety of cutaneous and extracutaneous findings in NF1 to which the dermatologist may be exposed.

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Section: Cutaneous Manifestationsmentioning

confidence: 99%

Neurofibromatosis type 1

Boyd¹,

Korf²,

Theos³

2009

Journal of the American Academy of Dermatology

436

365

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“…5,6 In pediatric populations, we found 6 reported cases of persistent localized pruritus in the head and neck or upper extremities due to brainstem or spinal cord tumors. [7][8][9][10] Of these children, 5 (83%) had café-au-lait macules, which were diagnosed as neurofibromatosis. Pruritus was unilateral in 4 cases (66%).…”

Section: Commentmentioning

confidence: 99%

Intractable Localized Pruritus as the Sole Manifestation of Intramedullary Tumor in a Child

Soltani-Arabshahi¹,

Vanderhooft²,

Hansen³

2013

JAMA Dermatol

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We recommend a detailed neurologic examination in any case of persistent localized pruritus, in the absence of primary dermatologic causes. Given the challenges of performing a reliable neurologic examination in children, neuroimaging might be considered in children with intractable localized pruritus of unknown etiology of the head and neck or upper extremity, even in the absence of focal neurologic deficits.

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“…Resection of the tumors improve symptoms in some cases, but is not necessarily effective in every case. 1,3 Because localized pruritus is a rare manifestation of CNS tumors, the early diagnosis is often challenging. In many reported cases, various dermatologic disorders, such as contact dermatitis and mastocytosis, are initially suspected, and the causal CNS tumors were not found until after extensive treatments or laboratory examination were performed.…”

Section: A Case Of Localized Pruritus On the Left Lower Leg In A Pati...mentioning

confidence: 99%

A case of localized pruritus on the left lower leg in a patient with spinal glioma

Sano

Ide

Hasegawa

et al. 2022

The Journal of Dermatology

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Localized pruritus: A presenting symptom of a spinal cord tumor in a child with features of neurofibromatosis

Cited by 10 publications

References 21 publications

Neurofibromatosis type 1

Neurofibromatosis type 1

Intractable Localized Pruritus as the Sole Manifestation of Intramedullary Tumor in a Child

A case of localized pruritus on the left lower leg in a patient with spinal glioma

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