Localized primary tumors of the pleura. An analysis of 40 cases

Dalton, Willard T.; A, Zolliker; McCaughey, W.; Jacques, J.; Kannerstein, M

doi:10.1002/1097-0142(197910)44:4<1465::aid-cncr2820440441>3.0.co;2-y

Cited by 178 publications

(82 citation statements)

References 19 publications

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“…SFTs with local or distant recurrences are often larger than 10 cm on presentation (3,6). Benign SFT of the pleura has a high cure rate and an 8% local recurrence rate that is usually amenable to curative re-excision, often with chest wall resection because of the propensity for local recurrence (16).…”

Section: Discussionsupporting

confidence: 83%

Recurrent Solitary Fibrous Tumor of the Pleura with Malignant Transformation and Non-islet Cell Tumor-induced Hypoglycemia due to Paraneoplastic Overexpression and Secretion of High-molecular-weight Insulin-like Growth Factor II

Tominaga¹,

Kawarasaki²,

Kanemoto³

et al. 2012

Intern. Med.

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A 41-year-old man was diagnosed with a solitary fibrous tumor (SFT) of the pleura in the posterior mediastinum. Despite two surgeries for excision, the SFT recurred and progressed with direct invasion of the chest wall and bone metastases. He was hospitalized because of cerebral infarction and presented with recurrent severe hypoglycemia fourteen years later. High-molecular-weight (HMW) insulin-like growth factor II (IGF-II) was identified in the serum and tumor using Western blotting and immunohistochemistry. These findings suggested that the cause of the recurrent severe hypoglycemia was SFT production of HMW IGF-II, a mediator of non-islet cell tumor-induced hypoglycemia (NICTH).Key words: solitary fibrous tumor of the pleura, non-islet cell tumor hypoglycemia, high-molecular-weight insulin-like growth factor II, platelet-derived growth factor receptor tyrosine kinase

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Section: Discussionsupporting

confidence: 83%

Recurrent Solitary Fibrous Tumor of the Pleura with Malignant Transformation and Non-islet Cell Tumor-induced Hypoglycemia due to Paraneoplastic Overexpression and Secretion of High-molecular-weight Insulin-like Growth Factor II

Tominaga¹,

Kawarasaki²,

Kanemoto³

et al. 2012

Intern. Med.

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“…From a histological point of view, these tumours may be, or appear to be, biphasic because they are able to envelop the bronchiolar epithelium [4,5], as in our patient. It may be very difficult to ascertain the biological behaviour of LFTP based on histological findings, because the benign and malignant variants often share the same pathological features; i.e.…”

Section: Discussionmentioning

confidence: 86%

Localized fibrous pleural tumour of the interlobular pleura

Sanguinetti¹,

Marchesani²,

Ranaldi³

et al. 1996

Eur Respir J

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Localized fibrous tumours of the pleura (LFTP) are rare, generally benign and asymptomatic neoplasms, which originate from the pleural layers. We report on the case of a 67 year old woman who had a 1.5 cm diameter pulmonary nodule in the right upper lobe, which had been found by chance.Video-assisted thoracoscopy (VAT) was used to excise the nodule. The diagnosis of localized fibrous tumour of the interlobar pleura was made on microscopic evaluation.After 17 months, the patient is well and her chest radiographic image is normal. Eur Respir J., 1996Respir J., , 9, 1094Respir J., -1096 CASE STUDYLocalized fibrous tumours of the pleura (LFTP) are rare neoplasms that generally arise from the visceral layer and project into the pleural cavity [1]. Although benign variants are more frequent, malignant forms have been described. In most cases, they are asymptomatic and discovered by chance on chest radiograph images taken for other reasons.We report on a case of benign LFT of the interlobar pleura, in which the tumour was recognized arising from the pleura and was removed with video-assisted thoracoscopy (VAT). Case reportA 67 year old, white, nonsmoking, asymptomatic woman came to our department for evaluation of a pulmonary nodule (1.5 cm diameter), which had been discovered by chance in the right upper lobe on a chest radiography performed during a general check-up for hypertension, which was being well-controlled by nifedipine. Upon admission, her physical examination, pulmonary function tests, blood chemical values, and electrocardiographic activity (ECG) were all normal.Computed tomography (CT) of the chest confirmed the presence of a pulmonary nodule, which had a smooth, round appearance with no evidence of calcifications; the mediastinum was not involved ( fig. 1). No previous chest radiograph was available for comparison with the current one. Brain and abdominal CT and mammography were normal.The nodule was not visible on bronchoscopy (Olympus BF TD20) due to its peripheral location. It was, therefore, sampled with fluoroscopically-guided fine needle aspiration (FNA) of the lung and the cytological examination showed only normal alveolar and bronchiolar cells. The patient was then sent to a thoracic surgeon for VAT to remove the lesion. During exploration, the tumour was found just under the visceral pleura of the right upper lobe and was easily removed thoracoscopically.Macroscopically, the tumour was a 1.5 cm diameter nodule, with a rounded, bosselated surface. Its parenchyma was greyish-white, without haemorrhage or necrosis; and areas with a whorled pattern were evident. Microscopically, fibrous areas of moderate cellularity were observed, with loosely arranged spindle-shaped or oval cells scattered haphazardly among strands of collagen. In other areas, the cells were closely packed and sometimes appeared to have anastomosing or interdigitating fascicles ( fig. 2a). These areas of increased cellularity displayed a small number of mitotic figures and also some nuclear pleomorphism ( fig. 2c and...

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“…Solitary fibrous tumors are usually benign, rarely recur locally with invasion of adjacent tissues and rarely metastasize. It has been reported that a small percentage of solitary fibrous tumors of the pleura and mediastinum have aggressive features such as tumor necrosis and large tumor size, as well as hypercellularity, high mitotic count (Ø4 per 10 HPF) and cellular pleomorphism (Witkin & Rosai 1989;England et al 1989;Dalton et al 1979). Solitary fibrous tumors with these aggressive features may manifest with invasion of adjacent tissue, recurrence or distant metastases (England et al 1989).…”

Section: Discussionmentioning

confidence: 99%