Localized Pleural Metastases of Renal Cell Carcinoma After Nephrectomy

Yasuda, Yuichiro; Tobino, Kazunori; Ko, Yuki; Asaji, Mina; Yamaji, Yoshikazu; Tsuruno, Kosuke; Mukasa, Yosuke; Ebi, Noriyuki

doi:10.1097/lbr.0000000000000181

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…A literature review by Yasuda et al evaluated seven cases of RCC with localized pleural metastases. The patients in all cases presented with malignant pleural effusions after having been previously diagnosed with RCC [ 5 ]. There is a paucity of data in the literature on the incidence of malignant pleural effusion as the initial presentation of RCC, with data primarily existing in case reports.…”

Section: Discussionmentioning

confidence: 99%

Malignant Pleural Effusion As the Initial Presentation of Renal Cell Carcinoma: A Case Report and Literature Review

Wasifuddin¹,

Ilerhunmwuwa²,

Hakobyan³

et al. 2023

Cureus

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Renal cell carcinoma is the most common renal neoplasm. Its presentation is often very occult, and it may be discovered incidentally. It may present with the classic symptoms of back pain, flank pain, hematuria, or hypertension. Renal cell carcinoma may also present with malignant pleural effusion at diagnosis; however, it is very rare. In this case report and literature review, we describe a 77-year-old male who was diagnosed with renal cell carcinoma after presenting with a malignant pleural effusion -an extremely rare phenomenon. An analysis of the literature yielded 13 case reports, including ours, where the diagnostic presentation of renal cell carcinoma was a malignant pleural effusion.Our patient presented with left-sided chest pain. Imaging was suggestive of pleural effusion. CT and MRI imaging demonstrated masses in the upper and lower poles of the right kidney suggestive of renal cell carcinoma. CT imaging also showed lung nodules that were suggestive of pulmonary metastases. Biopsy and immunostaining of pleural tissue were positive for clear cell renal cell carcinoma. Therapeutic thoracentesis was performed. Despite this, the patient developed recurrent large-volume pleural effusions requiring drainage and placement of a pleural catheter. Our patient's extremely rare presentation of malignant pleural effusion as the diagnostic presentation of renal cell carcinoma along with recurrent, large-volume effusions requiring drainage has only been reported in the form of case reports in the literature.

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Section: Discussionmentioning

confidence: 99%

Malignant Pleural Effusion As the Initial Presentation of Renal Cell Carcinoma: A Case Report and Literature Review

Wasifuddin¹,

Ilerhunmwuwa²,

Hakobyan³

et al. 2023

Cureus

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“…Pleural metastasis from renal cell carcinoma without pulmonary involvement is a rare condition, as most of the pleural metastases occur secondary to lung metastasis [ 1 , 3 ]. Yasuda et al [ 4 ] reported a case of carcinomatous pleuritis due to renal cell carcinoma, which occurred 10 years after nephrectomy. Although they reviewed 7 case reports of localized pleural metastases of renal cell carcinoma, all patients did not have pyrexia but dyspnea and showed pleural effusion on chest image.…”

Section: Discussionmentioning

confidence: 99%

Multiple circular pleural metastases of renal cell carcinoma

Kushima

Ishii

Kinoshita

et al. 2018

Respiratory Medicine Case Reports

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A 91-year-old woman was admitted with persistent pyrexia, anorexia and weight loss. A chest radiograph showed multiple circular masses of various sizes. Chest computed tomography revealed multiple pleural tumors without any lung lesion. The ultrasound-guided biopsy specimens demonstrated diffusely-proliferated tumor cells with clear or vacuolated cytoplasm, which were positive for CD10, PAX8, vimentin and CAM5.2, but were negative for mesothelial cell markers such as HBME-1 and thrombomodulin. These findings indicated metastatic clear cell carcinoma of the kidney, and a solitary renal tumor was observed on abdominal computed tomography. It has been reported that pleural metastases constituted 12% of patients with progressive renal cell carcinoma, and most of the pleural metastases occurred secondary to lung metastasis. This was a rare case of renal cell carcinoma with an unusual chest image via an intriguing metastatic pathway, which was limited to pleura.

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Localized pleural metastasis without other organ metastases after nephrectomy for renal cell carcinoma

Saito¹,

Hata²,

Nishioka³

et al. 2021

Respiratory Medicine Case Reports

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We present a case of a 69-year-old man who had localized pleural metastasis without other organ metastases after nephrectomy for right renal cell carcinoma (RCC). He complained of respiratory symptoms for more than two years after the operation and was confirmed to have right pleural effusion and multiple pleural masses on computed tomography (CT). There were no abnormal findings in the other organs, but the pleural mass gradually increased in size on CT. We suspected malignant tumors such as malignant pleural mesothelioma and synovial sarcoma in addition to RCC metastasis. Finally, we performed surgical resection of the pleural mass under general anesthesia, and we diagnosed pathologically as metastasis from RCC. Distant metastases of RCC are common in the lungs, bones, brain, and liver. To our knowledge, localized pleural metastases from RCC is rare.

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Localized Pleural Metastases of Renal Cell Carcinoma After Nephrectomy

Cited by 4 publications

References 11 publications

Malignant Pleural Effusion As the Initial Presentation of Renal Cell Carcinoma: A Case Report and Literature Review

Malignant Pleural Effusion As the Initial Presentation of Renal Cell Carcinoma: A Case Report and Literature Review

Multiple circular pleural metastases of renal cell carcinoma

Localized pleural metastasis without other organ metastases after nephrectomy for renal cell carcinoma

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