Localized persistent pulmonary interstitial emphysema

Rao, J. N. K.; Hochman, Mitchel I.; Miller, Grant G.

doi:10.1016/j.jpedsurg.2006.01.071

Cited by 18 publications

(16 citation statements)

References 3 publications

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“…In pulmonary interstitial emphysema (PIE) the process is initiated by a rupture of the small airways distal to the ending of their fascial sheets, followed by air‐dissection into the interstitium 1. Extension of these interstitial air displaces the adjacent lung parenchyma forming sometimes a bullous emphysema (BE) of varying size 2. Excessive gas accumulation may also be restricted to air conducting intrapulmonary structures.…”

Section: Introductionmentioning

confidence: 99%

Management of primary liver sarcomas

Weitz

Klimstra

Cymes

et al. 2007

Cancer

167

134

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BACKGROUNDPrimary hepatic sarcoma is a rare entity. The objectives of the study were to define treatment and long‐term outcome and to identify prognostic factors.METHODSBetween January 1981 and December 2004, 30 patients with primary sarcoma of the liver and 5 patients with primary carcinosarcoma of the liver were treated. Patient demographics, tumor characteristics, treatment, and actuarial survival were analyzed.RESULTSOf the 30 patients with primary hepatic sarcoma (10 epithelioid hemangioendothelioma, 5 embryonal sarcoma, 5 angiosarcoma, 3 solitary fibrous tumor, and 7 other types), 11 underwent R0‐resection and had a 5‐year disease‐specific survival of 64%. Of these 11 patients, 4 had low‐grade sarcoma and have not developed tumor recurrence. In the group of 7 patients with high‐grade sarcomas who underwent R0‐resection, both patients with angiosarcoma died within 11 months, whereas the 5 patients with embryonal sarcoma had a 5‐year disease‐free and disease‐specific survival of 80%. Six of the 10 patients with an epithelioid hemangioendothelioma were managed without surgery, as they had diffuse, slowly progressing, or stable lesions; these patients had a 5‐year disease‐specific survival of 67%. Of the remaining 13 patients in whom R0‐resection was not performed, there were no 3‐year survivors. The prognosis for patients with primary carcinosarcoma of the liver was poor, with all but 1 patient dying within a year and no 3‐year survivors.CONCLUSIONSThe outcome of patients with primary hepatic sarcoma depends primarily on tumor histology and the ability to achieve complete tumor resection. Improvements in outcome will require the development of more effective systemic therapies. Cancer 2007. © 2007 American Cancer Society.

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Section: Introductionmentioning

confidence: 99%

Management of primary liver sarcomas

Weitz

Klimstra

Cymes

et al. 2007

Cancer

167

134

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“…Conservative treatment by selective intubation, selective bronchial obstruction, or decubitus positioning is accepted as the initial management [3][4][5]. However, the giant pulmonary bulla can be considered for surgery [2,8,11].…”

Section: Discussionmentioning

confidence: 99%

“…Acquired cystic lung disease in premature infants is a serious respiratory complication of bronchopulmonary dysplasia (BPD) [1]. This includes various pathologies such as pulmonary interstitial emphysema (PIE) [2][3][4], pulmonary bulla [5], and pneumatocele [6]. Among acquired cystic lung diseases, most cases are reported as PIE.…”

Section: Introductionmentioning

confidence: 99%

Giant Pulmonary Bulla Underlying Bronchopulmonary Dysplasia in a Very Low-birth-weight Infant: a Case Report

Shinohara¹,

Hasebe²,

Watanabe³

et al. 2021

Preprint

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Background: Acquired cystic lung disease is a serious respiratory complication of bronchopulmonary dysplasia in premature infants. Most cases of acquired cystic lung disease underlying bronchopulmonary dysplasia involve pulmonary interstitial emphysema. Although this is a reversible condition, there are a few instances where surgery might be necessary. An accurate diagnosis is important to decide the therapeutic strategy for acquired cystic lung disease. Here, we report a rare case of a giant pulmonary bulla in an infant treated with bullectomy. Case presentation: A male infant born at 23 weeks of gestation with a birth weight of 524 g was initially diagnosed with respiratory distress syndrome. During mechanical ventilatory support, he presented with recurrent pneumothorax and a gradually expanding pulmonary cyst in the right lung. Chest CT at 5 months of age revealed a large cyst located in the subpleural area adjacent to the multiple cystic air spaces. These findings are consistent with the diagnosis of giant pulmonary bulla with pulmonary interstitial emphysema underlying bronchopulmonary dysplasia . At 9 months of age, the giant pulmonary bulla expanded further due to acute bronchitis for which he developed respiratory failure and obstructive shock. This warranted a bullectomy for the giant pulmonary bulla. After the operation, the unresected pulmonary interstitial emphysema lesion did not expand further. He is currently three years old and has no respiratory problems. Conclusions: This case demonstrated that chest CT is useful for providing valuable anatomical information necessary in deciding the treatment strategy for acquired cystic lung disease in infants.

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“…1,2 The occurrence of PIE is attributed to the effects of positive pressure ventilation and poorly compliant lungs. 3,4 The incidence of spontaneous air leak syndromes in premature infants is approximately 1 to 2%. There are a few cases of spontaneous PIE in patients on continuous positive airway pressure (CPAP), [5][6][7] with higher incidence in ventilated low birth weight infants, reported to be as high as 33% in this group.…”

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confidence: 99%

Refractory Pulmonary Interstitial Emphysema in Extreme Premature Newborn

Ali

Mallett

Miller

2021

AJP Rep

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Pulmonary interstitial emphysema (PIE) occurs when air leaks into the pulmonary interstitium due to overdistension of distal airways, it occurs mainly in neonates with respiratory distress syndrome who need positive pressure ventilation but has also been reported in spontaneously breathing infants. Herein, we report on an extremely low birth weight infant with severe persistent PIE, while on invasive mechanical ventilation (high-frequency oscillatory ventilation, high-frequency jet ventilation, and neurally adjust ventilator assist) managed successfully with 2 weeks of selective right lung ventilation after failure of more conservative measures, including shorter periods of right mainstem intubation, before the prolonged trial that was successful.

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Localized persistent pulmonary interstitial emphysema

Cited by 18 publications

References 3 publications

Management of primary liver sarcomas

Management of primary liver sarcomas

Giant Pulmonary Bulla Underlying Bronchopulmonary Dysplasia in a Very Low-birth-weight Infant: a Case Report

Refractory Pulmonary Interstitial Emphysema in Extreme Premature Newborn

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