Localized Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy: A Long-Term Outcome in 86 Patients With 104 Treated Eyes

Harada, Ken; Murakami, Naoya; Kitaguchi, Mayuka; Sekii, Shuhei; Takahashi, Kana; Yoshio, Kotaro; Inaba, Koji; Morota, Madoka; Ito, Yoshinori; Sumi, Minako; Suzuki, Shigenobu; Tobinai, Kensei; Umemura, Takashi; Itami, Jun

doi:10.1016/j.ijrobp.2013.11.235

Cited by 60 publications

(67 citation statements)

References 24 publications

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“…Twenty peer-reviewed articles were reviewed from 1997 to 2013 [4,8,12,14,15,16,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. All patients treated with radiation therapy only were recorded.…”

Section: Resultsmentioning

confidence: 99%

“…As EMZL is an indolent form of lymphoma, radiotherapy has long been the treatment of choice for localized disease [14,15,16]. Long-term survival and excellent local control have been documented with radiotherapy alone [4,9,10,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Long-term survival and excellent local control have been documented with radiotherapy alone [4,9,10,14,15]. It is estimated that using low to moderate radiotherapy doses (25-36 Gy) can obtain 95-100% of local control [4,11,17].…”

Section: Introductionmentioning

confidence: 99%

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Extranodal Marginal Zone Lymphoma of Ocular Adnexa: Outcomes following Radiation Therapy

Platt¹,

Zahrani²,

Singh

et al. 2017

Ocul Oncol Pathol

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Aim: The aim of this study was to report outcomes following radiation therapy in patients with biopsy-proven extranodal marginal zone lymphoma of the ocular adnexa and uvea. Methods: Records from a single institution were retrospectively reviewed from January 1997 to December 2015. The mean follow-up duration was 38 months (range 0-194). Radiation therapy was administered to 77 eyes (60 patients); 57 of the 77 eyes (74%) were treated with radiation only (range 20-36 Gy, median 15 fractions). Radiation cataract, radiation retinopathy, and optic neuropathy assessments were performed on all eyes treated with radiation. Results: 100% of the 47 patients treated with radiation therapy only had local control with an average dose of 26.5 Gy (median 25.2 [range 20-36] Gy; 150-200 cGy per fraction). Four patients lost 2 lines or more of vision after radiation. The most common complication of radiation therapy was cataract formation/progression in 19 eyes (25%). Radiation retinopathy was observed only in 1 patient (1%). Conclusion: Our results confirm that radiation therapy (median 25 Gy) for extranodal marginal zone lymphoma of the ocular adnexa is associated with high local control and low risk of visually significant complications.

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“…Twenty peer-reviewed articles were reviewed from 1997 to 2013 [4,8,12,14,15,16,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. All patients treated with radiation therapy only were recorded.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Extranodal Marginal Zone Lymphoma of Ocular Adnexa: Outcomes following Radiation Therapy

Platt¹,

Zahrani²,

Singh

et al. 2017

Ocul Oncol Pathol

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“…For ocular tumors, the first choice of treatment for MALT lymphoma is radiotherapy, which is associated with a good prognosis, with a 5-year survival rate of 97.6 % and a 10-year survival rate of 93.5 %. Chemotherapy is usually administered in the event of disease recurrence [18].…”

Section: Discussionmentioning

confidence: 99%

Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

et al. 2016

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The patient was a 74-year-old Japanese woman with rheumatoid arthritis (RA) who developed generalized lymphadenopathy with elevated levels of lactase dehydrogenase (LD), and soluble IL-2 receptor (sIL-2R). She was found to be positive for anti-human T-cell leukemia virus type 1 (HTLV-1) antibodies. Her symptoms and laboratory abnormalities spontaneously regressed after the cessation of methotrexate (MTX), suggesting that she had an MTX-associated lymphoproliferative disorder; however, her lymphadenopathy appeared again approximately 14 months later with LD and sIL-2R elevation. A histopathological analysis and Southern blotting of a lymph node biopsy specimen for HTLV-1 provirus supported the diagnosis of adult T-cell leukemia/lymphoma (ATL) (lymphoma type). These data confirmed that an HTLV-1 positive RA patient may develop ATL.

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“…2 More than half of the OALs are extranodal marginal zone B cell lymphomas of mucosa-associated lymphoid tissue lymphomas (MALT). 3 Less common B cell lymphoma subtypes include follicular lymphoma (FL), diffuse large B cell lymphoma (DLBCL), plasmacytoma, lymphoplasmacytic lymphoma, mantle cell lymphoma (MCL), and even hairy cell leukemia. 1,4,5 Because of distinctive epidemiologic patterns in different geographic areas as well as different environmental and genetic factors, several microbiologic agents, especially Chlamydophila psittaci, have been considered to play a role in the etiology of OAL.…”

Section: Introductionmentioning

confidence: 99%

Ocular Adnexal Lymphomas: Single-Center Experience

Özkan

Palamar

Tombuloğlu

et al. 2015

Clinical Lymphoma Myeloma and Leukemia

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Localized Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy: A Long-Term Outcome in 86 Patients With 104 Treated Eyes

Cited by 60 publications

References 24 publications

Extranodal Marginal Zone Lymphoma of Ocular Adnexa: Outcomes following Radiation Therapy

Extranodal Marginal Zone Lymphoma of Ocular Adnexa: Outcomes following Radiation Therapy

Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

Ocular Adnexal Lymphomas: Single-Center Experience

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