Localized nephrogenic fibrosing dermopathy: Aberrant dermal repairing?

Report: Cutaneous disorders in uremic patients on hemodialysis: an Egyptian case‐controlled study

“…Pseudoporphyria was found in one adult male patient (0.6%) in our study, whereas other investigators reported pseudoporphyria in 13% of 66 uremic adults 18 . Other specific cutaneous manifestations of uremia, such as NFD and CUA, were not found in our study group, possibly because these are rare disorders 19,20 …”

Quantitative assessment of dermal cellularity in nephrogenic systemic fibrosis: A diagnostic aid

“…6 Calcification, ossification, histiocytes, and osteoclast-like giant cells may be present. [14][15][16][17] Increased dermal elastic fibers may be highlighted by Verhoeff-van Gieson elastin stain. 6 Histologic mimics of NSF include normal-appearing skin, scleromyxedema, and eosinophilic fasciitis.…”

Revisiting nephrogenic systemic fibrosis in 6 kidney transplant recipients: A single-center experience

“…31 Numerous nonhematopoietic side effects of ESAs are recognized, including angiogenesis and enhancement of the fibrin-induced wound-healing response in rats via increased expression of inducible nitric oxide synthase protein within macrophages. 32 A recent case report by Deng et al 33 described the development of a localized scarlike plaque directly after intravenous infusion of erythropoietin. Considering these data, a potentially adverse effect of prolonged high doses of ESA in human beings, particularly in uremic patients with underlying inflammatory status, cannot be excluded as a possible contributory mechanism for some events observed in NSF.…”